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Brain Sci. 2016, 6(3), 21;

DBS for Obesity

Division of Pediatric Endocrinology, Children’s Hospital, University of São Paulo Medical School, São Paulo 05403-000, Brazil
Division of Functional Neurosurgery of Institute of Psychiatry, Department of Neurology, University of São Paulo Medical School, São Paulo 01060-970, Brazil
Department of Psychiatry, Institute of Psychiatry, University of São Paulo Medical School, São Paulo 01060-970, Brazil
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON M5T 1R8, Canada
Division of Neuroimaging, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
Author to whom correspondence should be addressed.
Academic Editors: Tipu Aziz and Alex Green
Received: 21 June 2016 / Revised: 9 July 2016 / Accepted: 12 July 2016 / Published: 18 July 2016
(This article belongs to the Special Issue Deep Brain Stimulation (DBS) Applications)
Full-Text   |   PDF [202 KB, uploaded 18 July 2016]   |   Review Reports


Obesity is a chronic, progressive and prevalent disorder. Morbid obesity, in particular, is associated with numerous comorbidities and early mortality. In patients with morbid obesity, pharmacological and behavioral approaches often have limited results. Bariatric surgery is quite effective but is associated with operative failures and a non-negligible incidence of side effects. In the last decades, deep brain stimulation (DBS) has been investigated as a neurosurgical modality to treat various neuropsychiatric disorders. In this article we review the rationale for selecting different brain targets, surgical results and future perspectives for the use of DBS in medically refractory obesity. View Full-Text
Keywords: deep brain stimulation; obesity; hypothalamus; nucleus accumbens deep brain stimulation; obesity; hypothalamus; nucleus accumbens
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Franco, R.; Fonoff, E.T.; Alvarenga, P.; Lopes, A.C.; Miguel, E.C.; Teixeira, M.J.; Damiani, D.; Hamani, C. DBS for Obesity. Brain Sci. 2016, 6, 21.

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