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3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus

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Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
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Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Patricia A. Broderick
Brain Sci. 2015, 5(2), 118-129; https://doi.org/10.3390/brainsci5020118
Received: 13 February 2015 / Revised: 24 March 2015 / Accepted: 7 April 2015 / Published: 15 April 2015
Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus. These results suggest that HMF has the ability to reduce neuroinflammation in the brain. View Full-Text
Keywords: 3,5,6,7,8,3′,4′-heptamethoxyflavone; anti-inflammation; hippocampus; microglia; IL-1β 3,5,6,7,8,3′,4′-heptamethoxyflavone; anti-inflammation; hippocampus; microglia; IL-1β
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Okuyama, S.; Miyoshi, K.; Tsumura, Y.; Amakura, Y.; Yoshimura, M.; Yoshida, T.; Nakajima, M.; Furukawa, Y. 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus. Brain Sci. 2015, 5, 118-129.

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