Mapping the Human Performance Envelope Through Multivariate Information Transfer
Highlights
- The human performance envelope (HPE) can be objectively quantified as the dynamic, polygonal area defined by the causal interactions of five core neurophysiological human factors: mental workload, attention, stress, vigilance, and effort.
- Optimal performance states (best) are characterized by a significantly larger HPE area and a denser, more interconnected network of human factors, whereas low-performance states (worst) exhibit a contracted HPE area and fragmented connectivity.
- The LASSO-regularized MVAR-cTE pipeline provides the first directed, multivariate neurophysiological model of the HPE, bridging a critical gap between theoretical concepts and operational human states and performance assessment.
- The finding that operational resilience is underpinned by integrated neurocognitive networks offers a new biomarker for adaptive system design and competency-based training in safety-critical domains.
Abstract
1. Introduction
2. Materials and Methods
2.1. Experimental Group
2.2. ATM Scenario and Experimental Protocol
2.3. Automation and Malfunction
- Conflict solver: It slightly modifies the speed of aircraft in conflict in order to increase the separation. The controller was informed of this action by a clock symbol in their track label.
- Situation awareness monitoring: This tool detects relevant information for ATCOs (i.e., aircraft compliancy to the planned 3D trajectory, communication status) and displays warning and alerts on the track label and a dedicated monitoring window.
- Conflict agenda: This tool shows in an agenda of incoming conflicts with detailed information within 15 NM.
- Highlighting of calling station: Whenever a pilot calls, the associated aircraft track label is highlighted on the radar screen.
- Reduce visual load: Specific information is filtered for non-relevant aircraft to reduce the visual load of the radar screen.
- Adapt STCA alert design: The short-term conflict alert design is enhanced in order to capture the attention of the air traffic controller.
- Controller pilot data link communication: Controller pilot data link communication allows for silent communication. It considerably helped to reduce ATCO workload linked to radio communication. The data link was activated in 60% of the traffic.
2.4. Behavioural and Subjective Measure
2.5. Neurophysiological Data Recording and Analysis
2.6. LASSO-Regularized MVAR-cTE Pipeline
2.7. MVAR Model Order Selection
2.8. LASSO Regularization Parameter λ Selection
2.9. Human Performance Envelope (HPE) Characterization
- PageRank (PR) is used to evaluate the importance of each node based on the number of incoming relationships and the rank of the related source nodes [65]. PR effectively returns the probability distribution representing the likelihood of visiting a particular node (i.e., HF) through a random traversal of the graph. Essentially, the PR assesses the importance of each HF based on its connectivity with other high-ranking nodes (i.e., HFs) in the graph. This means that nodes with a large number of inbound links from high-ranking nodes tend to have a higher PR score. The resulting probability distribution allows for understanding which nodes are more central or influential in the overall structure of the network. The PR of the i-th node (e.g., HF) was calculated by the following formulawhere d (damping factor) was set to 0.85, N is the total number of nodes (e.g., HFs = 5), M(i) the set of nodes j that has directed, functional connections pointing to node i, PR(j) the current PageRank score of the neighbouring node j that is connected to node i, and C(j) the total number of outgoing connections from node j to other brain regions. The factor “PR(j)/C(j)” represents the share of node j’s influence that flows to node i, and it can assume values within the range [0 ÷ 1].
- Graph Density (D) is a measure that indicates how many connections between nodes exist compared to how many connections between nodes are possible [66]. Since MVAR-cTE estimates a directed functional graph, for a directed graph with N vertices and E edges, the maximum number of possible edges is N(N − 1) and the density D is calculated as:The density of a graph (D) hence provides an indication of the strength of connections within the network. It represents the ratio between the actual number of connections present in the graph and the maximum number of connections that could exist considering all possible links between the nodes in the network. As a consequence, it can assume values within the range [0 ÷ 1]. A high D suggests a densely interconnected network, where most nodes are connected to each other. Conversely, a low D indicates a more dispersed or fragmented network, with few connections between nodes. Measuring the D of a graph allows for understanding the cohesion and complexity of relationships within the network, providing valuable information about its structure and its resilience to variations and external events.
- Shannon’s entropy (H) is essentially a measure of the uncertainty or information contained in a random data source. More precisely, it is the average amount of information produced by a stochastic data source [67,68]. When discussing “information,” it refers to how significant or surprising a new value in a variable is. If Shannon Entropy is high, it indicates that there are many different possibilities or a lot of variation in the data, so each new value obtained provides a considerable amount of additional information. Conversely, if entropy is low, it implies there are few possibilities or little variation, thus each new value does not contribute significantly to the information. To operationalize this for the HPE model, the directed cTE connectivity matrix (identified in Section 2.6) was first converted into a binary adjacency matrix () where 1 indicates a significant causal link and 0 indicates its absence. We then computed the Shannon Entropy of this binary pattern using a binning estimation methodwhere represents the probability distribution of the binary connectivity patterns. A high indicates a fragmented or disorganized connection pattern, suggesting a degradation in the controller’s integrated mental state. This captures the organizational “uncertainty” of the directed dependencies between HFs.
3. Results
3.1. Behavioural Results
3.2. ATCO ISA Results
3.3. SME ISA Results
3.4. MVAR Model Order Selection
| Controller ID | Model Order (p) |
|---|---|
| S1 | 7 |
| S2 | 5 |
| S3 | 8 |
| S4 | 9 |
| S5 | 9 |
| S6 | 7 |
| S7 | 4 |
| S8 | 11 |
| S9 | 9 |
| S10 | 5 |
| S11 | 7 |
| S12 | 11 |
| S13 | 7 |
| S14 | 4 |
| S15 | 5 |
| S16 | 10 |
| S17 | 6 |
3.5. HPE Results
3.6. HPE Corresponding to High and Low Performance
3.7. Correlation Between HPE and Performance Index
4. Discussion
- Missing neurometric values (NaNs) arising from artefact-rejected epochs were substituted using the synthetic minority over-sampling technique. This procedure could have introduced mild smoothing at imputed positions in HFs. Given the slow timescale of cognitive state dynamics (i.e., HFs), this effect was expected to be small, but it should be formally validated in future works.
- Controller performance assessments were derived from subjective ratings (SME and ATCO); therefore, they might not fully represent their operational performance in managing air traffic.
- The sample size consisted of twenty controllers; therefore, an enlarged group is needed to further validate the result. Additionally, validations in other contexts (e.g., automotive, surgery) will be considered.
- Other MVAR models will be considered to take into account non-linear connections among HFs (e.g., modification of the backward-in-time selection, and Partial Multivariate Information-based Non-uniform Embedding) for the HPE characterization.
- More HFs (e.g., engagement, mental fatigue) and neurophysiological parameters like heart rate, skin conductance, and eye tracking will be integrated into the HPE model definition for a more comprehensive and accurate understanding of dynamics for HPE characterization.
- The strategy of selecting extreme performance moments (best and worst) and then comparing corresponding HPE values using a paired t-test was susceptible to regression-to-the-mean effects. However, we wanted to test the original HPE theoretical model, that is, that the HPE polygon area is significantly larger at moments of peak performance than at moments of performance degradation. Future works performed in laboratory settings and controlled experimental conditions will allow for better investigation into this aspect over time and not only at specific time moments.
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
| AIC | Akaike Information Criterion |
| ATCO | Air Traffic Controller |
| ATM | Air Traffic Management |
| BIC | Bayesian Information Criterion |
| cTE | Conditional Transfer Entropy |
| D | Graph Density |
| EEG | Electroencephalography |
| ENAC | École Nationale de l’Aviation Civile |
| GC | Granger Causality |
| GFP | Global Field Power |
| HF | Human Factor |
| HPE | Human Performance Envelope |
| ISA | Instant Self-Assessment |
| LASSO | Least Absolute Shrinkage and Selection Operator |
| MVAR | Multivariate Autoregressive (model) |
| NaN | Not a Number |
| OLS | Ordinary Least Squares |
| PID | Partial Information Decomposition |
| PID-LASSO | Partial Information Decomposition—Least Absolute Shrinkage and Selection Operator |
| PR | PageRank |
| rmcorr | Repeated Measures Correlation |
| RT | Reaction Time |
| SESAR | Single European Sky ATM Research |
| SME | Subject Matter Expert |
| SS | State-Space (model) |
| STCA | Short-Term Conflict Alert |
| TE | Transfer Entropy |
| VAR | Vector Autoregressive (model) |
References
- Lundberg, J.; Arvola, M.; Palmerius, K.L. Human Autonomy in Future Drone Traffic: Joint Human–AI Control in Temporal Cognitive Work. Front. Artif. Intell. 2021, 4, 704082. [Google Scholar] [CrossRef]
- Kirwan, B. Human Factors Requirements for Human-AI Teaming in Aviation. Future Transp. 2025, 5, 42. [Google Scholar] [CrossRef]
- Durso, F.T.; Manning, C.A. Air Traffic Control. Rev. Hum. Factors Ergon. 2008, 36, 10–12. [Google Scholar] [CrossRef]
- Bittner, A.C.; Harbeson, M.M.; Kennedy, R.S.; Lundy, N.C. Assessing the Human Performance Envelope: A Brief Guide; SAE Technical Papers; SAE: Warrendale, PA, USA, 1985. [Google Scholar] [CrossRef]
- Edwards, T. Human Performance in Air Traffic Control. Ph.D. Thesis, University of Nottingham, Nottingham, UK, 2013. [Google Scholar]
- Silvagni, S.; Napoletano, L.; Graziani, I.; Le Blaye, P.; Rognin, L. Concept for Human Performance Envelope. Future Sky Safety 2015. Available online: https://www.futuresky-safety.eu/wp-content/uploads/2015/12/FSS_P6_DBL_D6.1-Concept-for-Human-Performance-Envelope_v2.0.pdf (accessed on 9 February 2026).
- Pritchett, A.R. Aviation Automation: General Perspectives and Specific Guidance for the Design of Modes and Alerts. Rev. Hum. Factors Ergon. 2009, 5, 82–113. [Google Scholar] [CrossRef]
- Ae, S.D.; Hollnagel, E. Human factors and folk models. Cogn. Technol. Work. 2004, 6, 79–86. [Google Scholar] [CrossRef]
- Hockey, R. The Psychology of Fatigue: Work, Effort and Control; Cambridge University Press: Cambridge, UK, 2011; pp. 1–272. [Google Scholar] [CrossRef]
- Hancock, P.A.; Warm, J.S. A dynamic model of stress and sustained attention. Hum. Factors 1989, 31, 519–537. [Google Scholar] [CrossRef] [PubMed]
- Chira, A.I.; Dumitrescu, A.; Moisoiu, C.S.; Tanase, C.A. Human Performance Envelope Model Study Using Pilot’s Measured Parameters. INCAS Bull. 2020, 12, 49–61. [Google Scholar] [CrossRef]
- Rusu, V.; Calefariu, G. Mathematical-heuristic modelling for human performance envelope. Hum. Syst. Manag. 2023, 42, 233–246. [Google Scholar] [CrossRef]
- Graziani, I.; Berberian, B.; Kirwan, B.; Le Blaye, P.; Napoletano, L.; Rognin, L.; Silvagni, S. Development of the Human Performance Envelope Concept for Cockpit HMI Design. In Proceedings of the HCI-Aero 2016 International Conference on Human-Computer Interaction in Aerospace, Paris, France, 14–16 September 2016. [Google Scholar]
- Biella, M. Human Performance Envelope: Overview of the Project and Technical Results. 2018. Available online: https://elib.dlr.de/123336/1/Human_performance_envelope_overview_of_the_project_and_techn_results.pdf (accessed on 9 February 2026).
- Dumitrescu, A.; Craciunescu, R.; Vulpe, A. Evaluation of Human Performance in Driving Scenarios. In Proceedings of the 25th International Symposium on Wireless Personal Multimedia Communications, WPMC, Herning, Denmark, 30 October–2 November 2022; Volume 2022-October, pp. 369–374. [Google Scholar] [CrossRef]
- Novelli, L.; Wollstadt, P.; Mediano, P.; Wibral, M.; Lizier, J.T. Large-scale directed network inference with multivariate transfer entropy and hierarchical statistical testing. Netw. Neurosci. 2019, 3, 827–847. [Google Scholar] [CrossRef] [PubMed]
- Antonacci, Y.; Astolfi, L.; Nollo, G.; Faes, L. Information Transfer in Linear Multivariate Processes Assessed through Penalized Regression Techniques: Validation and Application to Physiological Networks. Entropy 2020, 22, 732. [Google Scholar] [CrossRef]
- Antonacci, Y.; Toppi, J.; Pietrabissa, A.; Anzolin, A.; Astolfi, L. Measuring Connectivity in Linear Multivariate Processes with Penalized Regression Techniques. IEEE Access 2023, 12, 30638–30652. [Google Scholar] [CrossRef]
- Tibshirani, R. Regression Shrinkage and Selection via the Lasso. J. R. Stat. Soc. Ser. B 1996, 58, 267–288. [Google Scholar] [CrossRef]
- Meinshausen, N.; Bühlmann, P. High-dimensional graphs and variable selection with the Lasso. Ann. Stat. 2006, 34, 1436–1462. [Google Scholar] [CrossRef]
- Kirwan, B.; Devine, J. Human Performance in Air Traffic Management Safety A White Paper. European Organisation for the Safety of Air Navigation. 2010. Available online: https://skybrary.aero/sites/default/files/bookshelf/1404.pdf (accessed on 9 February 2026).
- Lizier, J.T.; Bertschinger, N.; Jost, J.; Wibral, M. Information Decomposition of Target Effects from Multi-Source Interactions: Perspectives on Previous, Current and Future Work. Entropy 2018, 20, 307. [Google Scholar] [CrossRef]
- Borghini, G.; Aricò, P.; Di Flumeri, G.; Cartocci, G.; Colosimo, A.; Bonelli, S.; Golfetti, A.; Imbert, J.P.; Granger, G.; Benhacene, R.; et al. EEG-Based Cognitive Control Behaviour Assessment: An Ecological study with Professional Air Traffic Controllers. Sci. Rep. 2017, 7, 547. [Google Scholar] [CrossRef]
- Save, L.; Feuerberg, B. Designing Human-Automation Interaction: A new level of Automation Taxonomy. In Human Factors of Systems and Technology; Shaker Publishing: Maastricht, The Netherlands, 2012. [Google Scholar]
- Ratcliff, R.; McKoon, G. The diffusion decision model: Theory and data for two-choice decision tasks. Neural Comput. 2008, 20, 873–922. [Google Scholar] [CrossRef] [PubMed]
- Heitz, R.P. The speed-accuracy tradeoff: History, physiology, methodology, and behavior. Front. Neurosci. 2014, 8, 86875. [Google Scholar] [CrossRef] [PubMed]
- Kruger, J.; Dunning, D. Unskilled and unaware of it: How difficulties in recognizing one’s own incompetence lead to inflated self-assessments. J. Pers. Soc. Psychol. 1999, 77, 1121–1134. [Google Scholar] [CrossRef] [PubMed]
- Tuhkala, A.; Heilala, V.; Lämsä, J.; Helovuo, A.; Tynkkynen, I.; Lampi, E.; Sipiläinen, K.; Hämäläinen, R.; Kärkkäinen, T. The interconnection between evaluated and self-assessed performance in full flight simulator training. Vocat. Learn. 2024, 17, 253–276. [Google Scholar] [CrossRef]
- Jurcak, V.; Tsuzuki, D.; Dan, I. 10/20, 10/10, and 10/5 systems revisited: Their validity as relative head-surface-based positioning systems. Neuroimage 2007, 34, 1600–1611. [Google Scholar] [CrossRef]
- Sciaraffa, N.; Di Flumeri, G.; Germano, D.; Giorgi, A.; Di Florio, A.; Borghini, G.; Vozzi, A.; Ronca, V.; Babiloni, F.; Aricò, P. Evaluation of a New Lightweight EEG Technology for Translational Applications of Passive Brain-Computer Interfaces. Front. Hum. Neurosci. 2022, 16, 458. [Google Scholar] [CrossRef] [PubMed]
- Ronca, V.; Di Flumeri, G.; Giorgi, A.; Vozzi, A.; Capotorto, R.; Germano, D.; Sciaraffa, N.; Borghini, G.; Babiloni, F.; Aricò, P. o-CLEAN: A novel multi-stage algorithm for the ocular artifacts’ correction from EEG data in out-of-the-lab applications. J. Neural Eng. 2024, 21, 056023. [Google Scholar] [CrossRef]
- Di Flumeri, G.; Arico, P.; Borghini, G.; Colosimo, A.; Babiloni, F. A new regression-based method for the eye blinks artifacts correction in the EEG signal, without using any EOG channel. In Proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, FL, USA, 16–20 August 2016; Volume 2016, pp. 3187–3190. [Google Scholar] [CrossRef]
- Delorme, A.; Makeig, S. EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J. Neurosci. Methods 2004, 134, 9–21. [Google Scholar] [CrossRef]
- Klimesch, W. EEG alpha and theta oscillations reflect cognitive and memory performance: A review and analysis. Brain Res. Rev. 1999, 29, 169–195. [Google Scholar] [CrossRef]
- Borghini, G.; Astolfi, L.; Vecchiato, G.; Mattia, D.; Babiloni, F. Measuring neurophysiological signals in aircraft pilots and car drivers for the assessment of mental workload, fatigue and drowsiness. Neurosci. Biobehav. Rev. 2014, 44, 58–75. [Google Scholar] [CrossRef] [PubMed]
- Ronca, V.; Uflaz, E.; Turan, O.; Bantan, H.; MacKinnon, S.N.; Lommi, A.; Pozzi, S.; Kurt, R.E.; Arslan, O.; Kurt, Y.B.; et al. Neurophysiological Assessment of An Innovative Maritime Safety System in Terms of Ship Operators’ Mental Workload, Stress, and Attention in the Full Mission Bridge Simulator. Brain Sci. 2023, 13, 1319. [Google Scholar] [CrossRef]
- Borghini, G.; Arico, P.; Di Flumeri, G.; Sciaraffa, N.; Di Florio, A.; Ronca, V.; Giorgi, A.; Mezzadri, L.; Gasparini, R.; Tartaglino, R.; et al. Real-time Pilot Crew’s Mental Workload and Arousal Assessment During Simulated Flights for Training Evaluation: A Case Study. In Proceedings of the 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Scotland, UK, 11–15 July 2022; Volume 2022, pp. 3568–3571. [Google Scholar] [CrossRef]
- Aricò, P.; Borghini, G.; Di Flumeri, G.; Colosimo, A.; Bonelli, S.; Golfetti, A.; Pozzi, S.; Imbert, J.-P.; Granger, G.; Benhacene, R.; et al. Adaptive Automation Triggered by EEG-Based Mental Workload Index: A Passive Brain-Computer Interface Application in Realistic Air Traffic Control Environment. Front. Hum. Neurosci. 2016, 10, 539. [Google Scholar] [CrossRef]
- Sciaraffa, N.; Di Flumeri, G.; Germano, D.; Giorgi, A.; Di Florio, A.; Borghini, G.; Vozzi, A.; Ronca, V.; Varga, R.; van Gasteren, M.; et al. Validation of a Light EEG-Based Measure for Real-Time Stress Monitoring during Realistic Driving. Brain Sci. 2022, 12, 304. [Google Scholar] [CrossRef]
- Sebastiani, M.; Di Flumeri, G.; Aricò, P.; Sciaraffa, N.; Babiloni, F.; Borghini, G. Neurophysiological Vigilance Characterisation and Assessment: Laboratory and Realistic Validations Involving Professional Air Traffic Controllers. Brain Sci. 2020, 10, 48. [Google Scholar] [CrossRef]
- Di Flumeri, G.; De Crescenzio, F.; Berberian, B.; Ohneiser, O.; Kramer, J.; Aricò, P.; Borghini, G.; Babiloni, F.; Bagassi, S.; Piastra, S. Brain–Computer Interface-Based Adaptive Automation to Prevent Out-of-The-Loop Phenomenon in Air Traffic Controllers Dealing with Highly Automated Systems. Front. Hum. Neurosci. 2019, 13, 469230. [Google Scholar] [CrossRef] [PubMed]
- Sciaraffa, N.; Borghini, G.; Di Flumeri, G.; Cincotti, F.; Babiloni, F.; Aricò, P. Joint Analysis of Eye Blinks and Brain Activity to Investigate Attentional Demand during a Visual Search Task. Brain Sci. 2021, 11, 562. [Google Scholar] [CrossRef]
- Simonetti, I.; Tamborra, L.; Giorgi, A.; Ronca, V.; Vozzi, A.; Aricò, P.; Borghini, G.; Sciaraffa, N.; Trettel, A.; Babiloni, F.; et al. Neurophysiological Evaluation of Students’ Experience during Remote and Face-to-Face Lessons: A Case Study at Driving School. Brain Sci. 2023, 13, 95. [Google Scholar] [CrossRef] [PubMed]
- Borghini, G.; Aricò, P.; Di Flumeri, G.; Ronca, V.; Giorgi, A.; Sciaraffa, N.; Conca, C.; Stefani, S.; Verde, P.; Landolfi, A.; et al. Air Force Pilot Expertise Assessment during Unusual Attitude Recovery Flight. Safety 2022, 8, 38. [Google Scholar] [CrossRef]
- Lütkepohl, H. New introduction to multiple time series analysis. In New introduction to Multiple Time Series Analysis; Springer: Berlin/Heidelberg, Germany, 2005; pp. 1–764. [Google Scholar] [CrossRef]
- Liu, S.; Molenaar, P.C.M. iVAR: A program for imputing missing data in multivariate time series using vector autoregressive models. Behav. Res. Methods 2014, 46, 1138–1148. [Google Scholar] [CrossRef]
- Sela, R.J.; Simonoff, J.S. RE-EM trees: A data mining approach for longitudinal and clustered data. Mach. Learn. 2011, 86, 169–207. [Google Scholar] [CrossRef]
- Chawla, N.V.; Bowyer, K.W.; Hall, L.O.; Kegelmeyer, W.P. SMOTE: Synthetic Minority Over-sampling Technique. J. Artif. Intell. Res. 2002, 16, 321–357. [Google Scholar] [CrossRef]
- Barnett, L.; Seth, A.K. Granger causality for state-space models. Phys. Rev. E 2015, 91, 040101. [Google Scholar] [CrossRef]
- Wen, X.; Rangarajan, G.; Ding, M. Multivariate Granger causality: An estimation framework based on factorization of the spectral density matrix. Philos. Trans. A Math. Phys. Eng. Sci. 2013, 371, 20110610. [Google Scholar] [CrossRef] [PubMed]
- Faes, L.; Marinazzo, D.; Stramaglia, S. Multiscale Information Decomposition: Exact Computation for Multivariate Gaussian Processes. Entropy 2017, 19, 408. [Google Scholar] [CrossRef]
- Stoorvogel, A.A.; Saberi, A. The discrete algebraic Riccati equation and linear matrix inequality. Linear Algebra Appl. 1998, 274, 317–365. [Google Scholar] [CrossRef]
- Faes, L.; Sparacino, L.; Mijatovic, G.; Antonacci, Y.; Ricci, L.; Marinazzo, D.; Stramaglia, S. Partial Information Rate Decomposition. Phys. Rev. Lett. 2025, 135, 187401. [Google Scholar] [CrossRef]
- Akaike, H. Information Theory and an Extension of the Maximum Likelihood Principle. In Selected Papers of Hirotugu Akaike; Springer: New York, NY, USA, 1998; Volume 1998, pp. 199–213. [Google Scholar] [CrossRef]
- Schwarz, G. Estimating the Dimension of a Model. Ann. Stat. 1978, 6, 461–464. [Google Scholar] [CrossRef]
- Ding, J.; Tarokh, V.; Yang, Y. Model Selection Techniques-An Overview. IEEE Signal Process. Mag. 2018, 35, 16–34. [Google Scholar] [CrossRef]
- Claeskens, G.; Hjort, N.L. Model Selection and Model Averaging; Cambridge University Press: Cambridge, UK, 2008; Volume 5, Available online: https://www.cambridge.org (accessed on 10 February 2026).
- Vrieze, S.I. Model selection and psychological theory: A discussion of the differences between the Akaike information criterion (AIC) and the Bayesian information criterion (BIC). Psychol. Methods 2012, 17, 228–243. [Google Scholar] [CrossRef]
- McQuarrie, A.D.R.; Tsai, C.-L. Regression and Time Series Model Selection; World Scientific Publishing: London, UK, 1998. [Google Scholar] [CrossRef]
- Arlot, S.; Celisse, A. A survey of cross-validation procedures for model selection. Stat. Surv. 2010, 4, 40–79. [Google Scholar] [CrossRef]
- Bergmeir, C.; Hyndman, R.J.; Koo, B. A note on the validity of cross-validation for evaluating autoregressive time series prediction. Comput. Stat. Data Anal. 2018, 120, 70–83. [Google Scholar] [CrossRef]
- Fallani, F.D.V.; Costa, L.d.F.; Rodriguez, F.A.; Astolfi, L.; Vecchiato, G.; Toppi, J.; Borghini, G.; Cincotti, F.; Mattia, D.; Salinari, S.; et al. A graph-theoretical approach in brain functional networks. Possible implications in EEG studies. Nonlinear Biomed. Phys. 2010, 4, S8. [Google Scholar] [CrossRef] [PubMed]
- Kuntzelman, K.; Miskovic, V. Reliability of graph metrics derived from resting-state human EEG. Psychophysiology 2017, 54, 51–61. [Google Scholar] [CrossRef]
- Lou, Y.; Pi, R.; Sun, R.; Wu, J.; Wang, W.; Zhu, Z.; Dai, T.; Gong, W. Graph theory-based analysis of functional connectivity changes in brain networks underlying cognitive fatigue: An EEG study. PLoS ONE 2025, 20, e0329212. [Google Scholar] [CrossRef] [PubMed]
- Ghaderi, A.H.; Baltaretu, B.R.; Andevari, M.N.; Bharmauria, V.; Balci, F. Synchrony and Complexity in State-Related EEG Networks: An Application of Spectral Graph Theory. Neural Comput. 2020, 32, 2422–2454. [Google Scholar] [CrossRef]
- Dattola, S.; Mammone, N.; Morabito, F.C.; Rosaci, D.; Sarné, G.M.L.; La Foresta, F. Testing Graph Robustness Indexes for EEG Analysis in Alzheimer’s Disease Diagnosis. Electronics 2021, 10, 1440. [Google Scholar] [CrossRef]
- Karaca, Y.; Moonis, M. Shannon entropy-based complexity quantification of nonlinear stochastic process: Diagnostic and predictive spatiotemporal uncertainty of multiple sclerosis subgroups. In Multi-Chaos, Fractal and Multi-Fractional Artificial Intelligence of Different Complex Systems; Academic Press: Cambridge, MA, USA, 2022; pp. 231–245. Available online: https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780323900324000183 (accessed on 10 February 2026).
- Torres-García, A.A.; Mendoza-Montoya, O.; Molinas, M.; Antelis, J.M.; Moctezuma, L.A.; Hernández-Del-Toro, T. Pre-processing and feature extraction. In Biosignal Processing and Classification Using Computational Learning and Intelligence: Principles, Algorithms, and Applications; Academic Press: Cambridge, MA, USA, 2021; pp. 59–91. [Google Scholar] [CrossRef]
- Bassett, D.S.; Bullmore, E. Small-world brain networks. Neuroscientist 2006, 12, 512–523. [Google Scholar] [CrossRef]
- Rubinov, M.; Sporns, O. Complex network measures of brain connectivity: Uses and interpretations. Neuroimage 2010, 52, 1059–1069. [Google Scholar] [CrossRef] [PubMed]
- Chen, S.; Xie, N.; Tang, Y.; Ji, Y.; He, Z.; Wang, Y.; Huang, X.; Fu, J.; Ge, M.; Liu, Q.; et al. Long-Term Brain–Computer Interface Functional Electrical Stimulation Enhances Neuroplasticity and Functional Recovery in Elderly Stroke: A 4.5-Year Longitudinal Study Integrating Electroencephalography Biomarkers and Clinical Assessments. Research 2025, 8, 2026. [Google Scholar] [CrossRef]
- Gechlik, J.; Sedrakyan, H. Gauss’s Area Formula for Irregular Shapes. Ohio J. Sch. Math. 2024, 97, 12–29. [Google Scholar] [CrossRef]
- Borghini, G.; Aricò, P.; Di Flumeri, G.; Sciaraffa, N.; Colosimo, A.; Herrero, M.-T.; Bezerianos, A.; Thakor, N.V.; Babiloni, F. A new perspective for the training assessment: Machine learning-based neurometric for augmented user’s evaluation. Front. Neurosci. 2017, 11, 251123. [Google Scholar] [CrossRef]
- Bakdash, J.Z.; Marusich, L.R. Repeated measures correlation. Front. Psychol. 2017, 8, 456. [Google Scholar] [CrossRef] [PubMed]
- Matthews, G.; Warm, J.S.; Reinerman, L.E.; Langheim, L.K.; Saxby, D.J. Task Engagement, Attention, and Executive Control. In Handbook of Individual Differences in Cognition; The Springer Series on Human Exceptionality; Springer: New York, NY, USA, 2010; pp. 205–230. [Google Scholar] [CrossRef]
- Parasuraman, R.; Wickens, C.D. Humans: Still vital after all these years of automation. Hum. Factors 2008, 50, 511–520. [Google Scholar] [CrossRef]









Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Share and Cite
Borghini, G.; Latrach, K.; Di Flumeri, G.; Aricò, P.; Ronca, V.; Giorgi, A.; Capotorto, R.; Ricci, A.; Bonelli, S.; Arrigoni, V.; et al. Mapping the Human Performance Envelope Through Multivariate Information Transfer. Brain Sci. 2026, 16, 518. https://doi.org/10.3390/brainsci16050518
Borghini G, Latrach K, Di Flumeri G, Aricò P, Ronca V, Giorgi A, Capotorto R, Ricci A, Bonelli S, Arrigoni V, et al. Mapping the Human Performance Envelope Through Multivariate Information Transfer. Brain Sciences. 2026; 16(5):518. https://doi.org/10.3390/brainsci16050518
Chicago/Turabian StyleBorghini, Gianluca, Khadija Latrach, Gianluca Di Flumeri, Pietro Aricò, Vincenzo Ronca, Andrea Giorgi, Rossella Capotorto, Alessia Ricci, Stefano Bonelli, Vanessa Arrigoni, and et al. 2026. "Mapping the Human Performance Envelope Through Multivariate Information Transfer" Brain Sciences 16, no. 5: 518. https://doi.org/10.3390/brainsci16050518
APA StyleBorghini, G., Latrach, K., Di Flumeri, G., Aricò, P., Ronca, V., Giorgi, A., Capotorto, R., Ricci, A., Bonelli, S., Arrigoni, V., Tomasello, P., Drogoul, F., Imbert, J. P., Granger, G., & Babiloni, F. (2026). Mapping the Human Performance Envelope Through Multivariate Information Transfer. Brain Sciences, 16(5), 518. https://doi.org/10.3390/brainsci16050518

