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Brain Sciences
Volume 13
Issue 2
10.3390/brainsci13020234
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Brief Report

Navigated Transcranial Magnetic Stimulation Motor Mapping and Diffusion Tensor Imaging Tractography for Diencephalic Tumor in Pediatric Patients

by
Valentina Baro
1,*,
Luca Sartori
1,
Samuel Luciano Caliri
1,
Giulia Melinda Furlanis
1,
Alberto D’Amico
1,
Giulia Meneghini
2,
Silvia Facchini
3,
Florinda Ferreri
4,5,
Maurizio Corbetta
2,3,6,
Luca Denaro
1 and
Andrea Landi
1
1
Pediatric and Functional Neurosurgery, Department of Neuroscience, University of Padova, 35128 Padova, Italy
2
Padova Neuroscience Center (PNC), University of Padova, 35128 Padova, Italy
3
Department of Neuroscience, University of Padova, 35128 Padova, Italy
4
Unit of Neurology, Unit of Clinical Neurophysiology and Study Center for Neurodegeneration (CESNE), Department of Neuroscience, University of Padua, 35128 Padua, Italy
5
Department of Clinical Neurophysiology, Kuopio University Hospital, University of Eastern Finland, 70211 Kuopio, Finland
6
Venetian Institute of Molecular Medicine (VIMM), 35128 Padova, Italy
*
Author to whom correspondence should be addressed.
Brain Sci. 2023, 13(2), 234; https://doi.org/10.3390/brainsci13020234
Submission received: 16 December 2022 / Revised: 19 January 2023 / Accepted: 24 January 2023 / Published: 30 January 2023
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Brain Tumors and Nervous System Tumors)
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Abstract

Background. In deep-seated brain tumors, adequate preoperative planning is mandatory to assess the best surgical corridor to obtain maximal safe resection. Functional diffusor tensor imaging (DTI) tractography based on navigated transcranial magnetic stimulation (nTMS) motor mapping has proven to be a valid preoperative examination method in adults. The aim of this paper is to present the application of nTMS and functional DTI tractography in a series of pediatric diencephalic tumors. Material and methods. Three patients affected by thalamic (one) and thalamopeduncular tumor (two) were successfully examined with nTMS motor mapping and DTI tractography between October 2020 and October 2021 (F:M 3:0, mean age 12 years ± 0.8). Cortical representation of leg, hand and mouth were determined in the affected hemisphere and the positive stimulation spots were set as seeds point for tractography. Results. Mapping of the motor cortex and tracts reconstruction for leg and hand were successful in all patients, while facial function was properly mapped in one patient only. In all cases, the procedure was well tolerated and no adverse events were recorded. Spatial relationships between tumor and functional tissue guided the surgical planning. Extent of the resection varied from 96.1% to 100% with a postoperative new motor deficit in one patient. Conclusions. nTMS and DTI fiber tracking is a feasible, effective and well-tolerated method to identify motor pathway in deep-seated lesion in pediatric population.
Keywords: thalamopeduncolar tumor; thalamic tumor; children; nTMS; corticospinal tract thalamopeduncolar tumor; thalamic tumor; children; nTMS; corticospinal tract

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MDPI and ACS Style

Baro, V.; Sartori, L.; Caliri, S.L.; Furlanis, G.M.; D’Amico, A.; Meneghini, G.; Facchini, S.; Ferreri, F.; Corbetta, M.; Denaro, L.; et al. Navigated Transcranial Magnetic Stimulation Motor Mapping and Diffusion Tensor Imaging Tractography for Diencephalic Tumor in Pediatric Patients. Brain Sci. 2023, 13, 234. https://doi.org/10.3390/brainsci13020234

AMA Style

Baro V, Sartori L, Caliri SL, Furlanis GM, D’Amico A, Meneghini G, Facchini S, Ferreri F, Corbetta M, Denaro L, et al. Navigated Transcranial Magnetic Stimulation Motor Mapping and Diffusion Tensor Imaging Tractography for Diencephalic Tumor in Pediatric Patients. Brain Sciences. 2023; 13(2):234. https://doi.org/10.3390/brainsci13020234

Chicago/Turabian Style

Baro, Valentina, Luca Sartori, Samuel Luciano Caliri, Giulia Melinda Furlanis, Alberto D’Amico, Giulia Meneghini, Silvia Facchini, Florinda Ferreri, Maurizio Corbetta, Luca Denaro, and et al. 2023. "Navigated Transcranial Magnetic Stimulation Motor Mapping and Diffusion Tensor Imaging Tractography for Diencephalic Tumor in Pediatric Patients" Brain Sciences 13, no. 2: 234. https://doi.org/10.3390/brainsci13020234

APA Style

Baro, V., Sartori, L., Caliri, S. L., Furlanis, G. M., D’Amico, A., Meneghini, G., Facchini, S., Ferreri, F., Corbetta, M., Denaro, L., & Landi, A. (2023). Navigated Transcranial Magnetic Stimulation Motor Mapping and Diffusion Tensor Imaging Tractography for Diencephalic Tumor in Pediatric Patients. Brain Sciences, 13(2), 234. https://doi.org/10.3390/brainsci13020234

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