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Article

Transcriptome Sequencing Reveal That Rno-Rsf1_0012 Participates in Levodopa-Induced Dyskinesia in Parkinson’s Disease Rats via Binding to Rno-mir-298-5p

by
Chun-Lei Han
1,2,†,
Qiao Wang
2,3,†,
Chong Liu
2,3,
Zhi-Bao Li
2,3,
Ting-Ting Du
2,3,
Yun-Peng Sui
2,3,
Xin Zhang
2,3,
Jian-Guo Zhang
1,2,3,
Yi-Lei Xiao
4,*,
Guo-En Cai
5,6,* and
Fan-Gang Meng
1,2,3,7,*
1
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
2
Beijing Key Laboratory of Neurostimulation, Beijing 100070, China
3
Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China
4
Department of Neurosurgery, Liaocheng People’s Hospital, Liaocheng 252004, China
5
Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China
6
Fujian Key Laboratory of Molecular Neurology, Institute of Clinical Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou 350122, China
7
Chinese Institute for Brain Research, Beijing 102206, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Brain Sci. 2022, 12(9), 1206; https://doi.org/10.3390/brainsci12091206
Submission received: 10 August 2022 / Revised: 22 August 2022 / Accepted: 2 September 2022 / Published: 7 September 2022
(This article belongs to the Special Issue New Insights into Molecular Mechanisms Underlying Neurodegenerative Disorders)
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Abstract

Levodopa-induced dyskinesia (LID) is a common complication of chronic dopamine replacement therapy in the treatment of Parkinson’s disease (PD), and a noble cause of disability in advanced PD patients. Circular RNA (circRNA) is a novel type of non-coding RNA with a covalently closed-loop structure, which can regulate gene expression and participate in many biological processes. However, the biological roles of circRNAs in LID are not completely known. In the present study, we established typical LID rat models by unilateral lesions of the medial forebrain bundle and repeated levodopa therapy. High-throughput next-generation sequencing was used to screen circRNAs differentially expressed in the brain of LID and non-LID (NLID) rats, and key circRNAs were selected according to bioinformatics analyses. Regarding fold change ≥2 and p < 0.05 as the cutoff value, there were a total of 99 differential circRNAs, including 39 up-regulated and 60 down-regulated circRNAs between the NLID and LID groups. The expression of rno-Rsf1_0012 was significantly increased in the striatum of LID rats and competitively bound rno-mir-298-5p. The high expression of target genes PCP and TBP in LID rats also supports the conclusion that rno-Rsf1_0012 may be related to the occurrence of LID.
Keywords: Parkinson’s disease; levodopa-induced dyskinesia; circular RNA; next-generation sequencing Parkinson’s disease; levodopa-induced dyskinesia; circular RNA; next-generation sequencing

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MDPI and ACS Style

Han, C.-L.; Wang, Q.; Liu, C.; Li, Z.-B.; Du, T.-T.; Sui, Y.-P.; Zhang, X.; Zhang, J.-G.; Xiao, Y.-L.; Cai, G.-E.; et al. Transcriptome Sequencing Reveal That Rno-Rsf1_0012 Participates in Levodopa-Induced Dyskinesia in Parkinson’s Disease Rats via Binding to Rno-mir-298-5p. Brain Sci. 2022, 12, 1206. https://doi.org/10.3390/brainsci12091206

AMA Style

Han C-L, Wang Q, Liu C, Li Z-B, Du T-T, Sui Y-P, Zhang X, Zhang J-G, Xiao Y-L, Cai G-E, et al. Transcriptome Sequencing Reveal That Rno-Rsf1_0012 Participates in Levodopa-Induced Dyskinesia in Parkinson’s Disease Rats via Binding to Rno-mir-298-5p. Brain Sciences. 2022; 12(9):1206. https://doi.org/10.3390/brainsci12091206

Chicago/Turabian Style

Han, Chun-Lei, Qiao Wang, Chong Liu, Zhi-Bao Li, Ting-Ting Du, Yun-Peng Sui, Xin Zhang, Jian-Guo Zhang, Yi-Lei Xiao, Guo-En Cai, and et al. 2022. "Transcriptome Sequencing Reveal That Rno-Rsf1_0012 Participates in Levodopa-Induced Dyskinesia in Parkinson’s Disease Rats via Binding to Rno-mir-298-5p" Brain Sciences 12, no. 9: 1206. https://doi.org/10.3390/brainsci12091206

APA Style

Han, C.-L., Wang, Q., Liu, C., Li, Z.-B., Du, T.-T., Sui, Y.-P., Zhang, X., Zhang, J.-G., Xiao, Y.-L., Cai, G.-E., & Meng, F.-G. (2022). Transcriptome Sequencing Reveal That Rno-Rsf1_0012 Participates in Levodopa-Induced Dyskinesia in Parkinson’s Disease Rats via Binding to Rno-mir-298-5p. Brain Sciences, 12(9), 1206. https://doi.org/10.3390/brainsci12091206

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