Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Electroacupuncture Treatment
2.3. Sepsis-Associated Encephalopathy Model
2.4. Y Maze Test
2.5. Western Blotting
2.6. Immunofluorescence (IF)
2.7. Statistical Analyses
3. Results
3.1. EA Mitigated Working Memory Impairment Caused by LPS
3.2. EA Modulated the HMGB1 Signaling in the Hippocampus
3.3. EA Alleviated Neuroinflammation in the Hippocampus
3.4. EA Did Not Affect the Tight Junctions’ Expression of BBB in the Hippocampus
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Xin, Y.; Wang, J.; Chu, T.; Zhou, Y.; Liu, C.; Xu, A. Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy. Brain Sci. 2022, 12, 1732. https://doi.org/10.3390/brainsci12121732
Xin Y, Wang J, Chu T, Zhou Y, Liu C, Xu A. Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy. Brain Sciences. 2022; 12(12):1732. https://doi.org/10.3390/brainsci12121732
Chicago/Turabian StyleXin, Yueyang, Jinxu Wang, Tiantian Chu, Yaqun Zhou, Cheng Liu, and Aijun Xu. 2022. "Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy" Brain Sciences 12, no. 12: 1732. https://doi.org/10.3390/brainsci12121732