A Novel Improved Thromboembolism-Based Rat Stroke Model That Meets the Latest Standards in Preclinical Studies
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Animal Model
2.3. Horizontal Runway Elevated Test
2.4. Sample Preparation and Nissl Staining
2.5. Statistical Analysis
3. Results
3.1. Characterization of The Peri-Infarct Area following Ischemic Stroke
3.2. Characteristics of Motor Changes following Ischemic Stroke
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pawletko, K.; Jędrzejowska-Szypułka, H.; Bogus, K.; Pascale, A.; Fahmideh, F.; Marchesi, N.; Grajoszek, A.; Olakowska, E.; Barski, J.J. A Novel Improved Thromboembolism-Based Rat Stroke Model That Meets the Latest Standards in Preclinical Studies. Brain Sci. 2022, 12, 1671. https://doi.org/10.3390/brainsci12121671
Pawletko K, Jędrzejowska-Szypułka H, Bogus K, Pascale A, Fahmideh F, Marchesi N, Grajoszek A, Olakowska E, Barski JJ. A Novel Improved Thromboembolism-Based Rat Stroke Model That Meets the Latest Standards in Preclinical Studies. Brain Sciences. 2022; 12(12):1671. https://doi.org/10.3390/brainsci12121671
Chicago/Turabian StylePawletko, Katarzyna, Halina Jędrzejowska-Szypułka, Katarzyna Bogus, Alessia Pascale, Foroogh Fahmideh, Nicoletta Marchesi, Aniela Grajoszek, Edyta Olakowska, and Jarosław Jerzy Barski. 2022. "A Novel Improved Thromboembolism-Based Rat Stroke Model That Meets the Latest Standards in Preclinical Studies" Brain Sciences 12, no. 12: 1671. https://doi.org/10.3390/brainsci12121671