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Article

High-Intensity Interval Training-Induced Hippocampal Molecular Changes Associated with Improvement in Anxiety-like Behavior but Not Cognitive Function in Rats with Type 2 Diabetes

1
Toxicology Research Center, Aja University of Medical Sciences, Tehran 1411718541, Iran
2
Neuroscience Research Center, Institute of Neuropharmacology, Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman 7616914115, Iran
3
Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Bahonar University, Kerman 7616913439, Iran
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Sirjan School of Medical Sciences, Sirjan 7816916338, Iran
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Department of Pharmacology, School of Medicine, Aja University of Medical Sciences, Tehran 1411718541, Iran
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Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616914115, Iran
7
Faculty of Sport Sciences, Institute of Sports Nutrition, Waseda University, Saitama 359-1192, Japan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Eric S. Drollette and Brian A Coffman
Brain Sci. 2022, 12(10), 1280; https://doi.org/10.3390/brainsci12101280
Received: 3 August 2022 / Revised: 1 September 2022 / Accepted: 16 September 2022 / Published: 23 September 2022
(This article belongs to the Section Behavioral Neuroscience)
(1) Background: Exercise exerts many neuroprotective effects in diabetes-induced brain disorders. In this study, we investigated the effect of high-intensity interval training (HIIT) on brain molecular changes and cognitive and anxiety-like behaviors in rats with type 2 diabetes. (2) Methods: Twenty-eight adult male rats were divided into four groups (n = 7): control (C), exercise + control (C+EX), diabetes (DM), and diabetes + exercise (DM+EX). Diabetes was induced using a two-month high-fat diet and a single dose of streptozotocin (35 mg/kg) in the DM and DM+EX groups. After, the C+EX and DM+EX groups performed HIIT for eight weeks (five sessions per week, running at 80–100% of VMax, 4–10 intervals) on a motorized treadmill. Then, the elevated plus maze (EPM) and open field test (OFT) were performed to evaluate anxiety-like behaviors. The Morris water maze (MWM) and shuttle box were used to assess cognitive function. The hippocampal levels of beta-amyloid and tau protein were also assessed using Western blot. (3) Results: The hippocampal levels of beta-amyloid and tau protein were increased in the DM group, but HIIT restored these changes. While diabetes led to a significant decrease in open arm time percentage (%OAT) and open arm enters percentage (%OAE) in the EPM, indicating anxiety-like behavior, HIIT restored them. In the OFT, grooming was decreased in diabetic rats, which was restored by HIIT. No significant difference between groups was seen in the latency time in the shuttle box or for learning and memory in the MWM. (4) Conclusions: HIIT-induced hippocampal molecular changes were associated with anxiety-like behavior improvement but not cognitive function in rats with type 2 diabetes. View Full-Text
Keywords: exercise; type 2 diabetes; anxiety-like behaviors; learning and memory; beta-amyloid; tau protein exercise; type 2 diabetes; anxiety-like behaviors; learning and memory; beta-amyloid; tau protein
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MDPI and ACS Style

Orumiyehei, A.; Khoramipour, K.; Rezaei, M.H.; Madadizadeh, E.; Meymandi, M.S.; Mohammadi, F.; Chamanara, M.; Bashiri, H.; Suzuki, K. High-Intensity Interval Training-Induced Hippocampal Molecular Changes Associated with Improvement in Anxiety-like Behavior but Not Cognitive Function in Rats with Type 2 Diabetes. Brain Sci. 2022, 12, 1280. https://doi.org/10.3390/brainsci12101280

AMA Style

Orumiyehei A, Khoramipour K, Rezaei MH, Madadizadeh E, Meymandi MS, Mohammadi F, Chamanara M, Bashiri H, Suzuki K. High-Intensity Interval Training-Induced Hippocampal Molecular Changes Associated with Improvement in Anxiety-like Behavior but Not Cognitive Function in Rats with Type 2 Diabetes. Brain Sciences. 2022; 12(10):1280. https://doi.org/10.3390/brainsci12101280

Chicago/Turabian Style

Orumiyehei, Amin, Kayvan Khoramipour, Maryam Hossein Rezaei, Elham Madadizadeh, Manzumeh Shamsi Meymandi, Fatemeh Mohammadi, Mohsen Chamanara, Hamideh Bashiri, and Katsuhiko Suzuki. 2022. "High-Intensity Interval Training-Induced Hippocampal Molecular Changes Associated with Improvement in Anxiety-like Behavior but Not Cognitive Function in Rats with Type 2 Diabetes" Brain Sciences 12, no. 10: 1280. https://doi.org/10.3390/brainsci12101280

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