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Case Report

Increased Pupil Size during Future Thinking in a Subject with Retrograde Amnesia

1
CHU de Nantes, Inserm CIC04, 44000 Nantes, France
2
CHU de Nantes, Department of Neurology, Centre Mémoire de Ressources et Recherche, 44000 Nantes, France
3
Laboratoire de Psychologie des Pays de la Loire, Nantes Université, Univ Angers, 44000 Nantes, France
4
Unité de Gériatrie, Centre Hospitalier de Tourcoing, 59200 Tourcoing, France
5
Institut Universitaire de France, 75000 Paris, France
*
Author to whom correspondence should be addressed.
Academic Editors: Valerio Santangelo and Paul E. Engelhardt
Brain Sci. 2022, 12(1), 115; https://doi.org/10.3390/brainsci12010115
Received: 31 December 2021 / Accepted: 8 January 2022 / Published: 15 January 2022
(This article belongs to the Section Behavioral Neuroscience)
Recent research has assessed pupil size during past thinking in patients with retrograde amnesia. Building on this research, we assessed pupil size during future thinking in a retrograde amnesia patient. To this end, we measured pupil size during past and future thinking in L, a 19-year-old, right-handed man free of neurological/psychiatric disorders except for retrograde amnesia that occurred after an episode of fugue. During a past thinking condition, we invited L to retrieve retrograde events (i.e., events that occurred before amnesia) and anterograde events (i.e., events that occurred after amnesia). During a future thinking condition, we invited him to imagine events that might occur the following week, the following month, and in the new year. Past and future thinking occurred while L’s pupil size was monitored with eye-tracking glasses. L demonstrated higher specificity during future than during past thinking. Critically, the results demonstrated a larger pupil size during future than during past thinking. The larger pupil size during future thinking observed in L can be attributed to the high cognitive load involved in future thinking. Our study not only demonstrates preserved future thinking in a patient with dissociative retrograde amnesia, but also shows that pupillometry can be used for the physiological assessment of future thinking in retrograde amnesia patients. View Full-Text
Keywords: future thinking; pupil; pupillometry; retrograde amnesia future thinking; pupil; pupillometry; retrograde amnesia
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MDPI and ACS Style

Boutoleau-Bretonnière, C.; Lamy, E.; El Haj, M. Increased Pupil Size during Future Thinking in a Subject with Retrograde Amnesia. Brain Sci. 2022, 12, 115. https://doi.org/10.3390/brainsci12010115

AMA Style

Boutoleau-Bretonnière C, Lamy E, El Haj M. Increased Pupil Size during Future Thinking in a Subject with Retrograde Amnesia. Brain Sciences. 2022; 12(1):115. https://doi.org/10.3390/brainsci12010115

Chicago/Turabian Style

Boutoleau-Bretonnière, Claire, Estelle Lamy, and Mohamad El Haj. 2022. "Increased Pupil Size during Future Thinking in a Subject with Retrograde Amnesia" Brain Sciences 12, no. 1: 115. https://doi.org/10.3390/brainsci12010115

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