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Article

Neural Interruption by Unilateral Labyrinthectomy Biases the Directional Preference of Otolith-Related Vestibular Neurons

by 1,2, 1,2 and 1,*
1
Research Institute for Aerospace Medicine, Inha University, Incheon 22332, Korea
2
Department of Otorhinolaryngology Head & Neck Surgery, Inha University Hospital, Incheon 22332, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Manuel Sánchez Malmierca
Brain Sci. 2021, 11(8), 987; https://doi.org/10.3390/brainsci11080987
Received: 31 May 2021 / Revised: 13 July 2021 / Accepted: 22 July 2021 / Published: 26 July 2021
Background: The directional preference of otolith-related vestibular neurons elucidates the neuroanatomical link of labyrinths, but few direct experimental data have been provided. Methods: The directional preference of otolith-related vestibular neurons was measured in the vestibular nucleus using chemically induced unilateral labyrinthectomy (UL). For the model evaluation, static and dynamic behavioral tests as well as a histological test were performed. Extracellular neural activity was recorded for the neuronal responses to the horizontal head rotation and the linear head translation. Results: Seventy-seven neuronal activities were recorded, and the total population was divided into three groups: left UL (20), sham (35), and right UL (22). Based on directional preference, two sub-groups were again classified as contra- and ipsi-preferred neurons. There was no significance in the number of those sub-groups (contra-, 15/35, 43%; ipsi-, 20/35, 57%) in the sham (p = 0.155). However, more ipsi-preferred neurons (19/22, 86%) were observed after right UL (p = 6.056 × 10−5), while left UL caused more contra-preferred neurons (13/20, 65%) (p = 0.058). In particular, the convergent neurons mainly led this biased difference (ipsi-, 100% after right UL and contra-, 89% after left UL) (p < 0.002). Conclusions: The directional preference of the neurons depended on the side of the lesion, and its dominance was mainly led by the convergent neurons. View Full-Text
Keywords: directional preference; vestibular nucleus; otolith-related vestibular neuron; unilateral labyrinthectomy directional preference; vestibular nucleus; otolith-related vestibular neuron; unilateral labyrinthectomy
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MDPI and ACS Style

Nguyen, N.; Kim, K.-S.; Kim, G. Neural Interruption by Unilateral Labyrinthectomy Biases the Directional Preference of Otolith-Related Vestibular Neurons. Brain Sci. 2021, 11, 987. https://doi.org/10.3390/brainsci11080987

AMA Style

Nguyen N, Kim K-S, Kim G. Neural Interruption by Unilateral Labyrinthectomy Biases the Directional Preference of Otolith-Related Vestibular Neurons. Brain Sciences. 2021; 11(8):987. https://doi.org/10.3390/brainsci11080987

Chicago/Turabian Style

Nguyen, Nguyen, Kyu-Sung Kim, and Gyutae Kim. 2021. "Neural Interruption by Unilateral Labyrinthectomy Biases the Directional Preference of Otolith-Related Vestibular Neurons" Brain Sciences 11, no. 8: 987. https://doi.org/10.3390/brainsci11080987

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