Systems Biology Reveals S-Nitrosylation-Dependent Regulation of Mitochondrial Functions in Mice with Shank3 Mutation Associated with Autism Spectrum Disorder
Abstract
:1. Introduction
2. Methods and Materials
2.1. Cortical Tissue Preparation for MS Analysis
2.2. MS Analysis
2.3. Bioinformatics and Systems Biology Analysis
3. Results
3.1. Systems Biology Analysis of the S-Nitroso-Proteome in the ASD Mouse Model
3.2. Protein–Protein Interaction Network of the Mitochondrial SNO Proteins
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Accession ID | Protein’s Name |
---|---|
Q03265 | ATP synthase subunit alpha, mitochondrial |
Q99KI0 | Aconitate hydratase, mitochondrial |
P05202 | Aspartate aminotransferase, mitochondrial |
P30275 | Creatine kinase U-type, mitochondrial |
P39053 | Dynamin-1 |
P51881 | ADP/ATP translocase 2 |
P63328 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
P18760 | Cofilin-1 |
Q80VP2 | Spermatogenesis-associated protein 7 homolog |
Q8BMK0 | Centrosomal protein of 85 kDa |
P48754 | Breast cancer type 1 susceptibility protein homolog |
Q499E0 | Protein FAM5C |
D3Z7P3 | Glutaminase kidney isoform, mitochondrial |
O70337 | Bcl-2-interacting killer |
Q3U7U3 | F-box only protein 7 |
Q924D0 | Reticulon-4-interacting protein 1, mitochondrial |
P62897 | Cytochrome c, somatic |
P51612 | DNA repair protein complementing XP-C cells homolog |
Q8CBB9 | Radical S-adenosyl methionine domain-containing protein 2 |
P56564 | Excitatory amino acid transporter 1 |
O70372 | Telomerase reverse transcriptase |
Q9CPQ1 | Cytochrome c oxidase subunit 6C |
P50171 | Estradiol 17-beta-dehydrogenase 8 |
Q9R1M5 | NACHT, LRR and PYD domains-containing protein 5 |
Q8BH59 | Calcium-binding mitochondrial carrier protein Aralar1 |
P62908 | 40S ribosomal protein S3 |
Q02566 | Myosin-6 |
Q03137 | Ephrin type-A receptor 4 |
P0CG49 | Polyubiquitin-B |
O55042 | Alpha-synuclein |
P97450 | ATP synthase-coupling factor 6, mitochondrial |
P48962 | ADP/ATP translocase 1 |
P08249 | Malate dehydrogenase, mitochondrial |
P28184 | Metallothionein-3 |
P11531 | Dystrophin |
P70296 | Phosphatidylethanolamine-binding protein 1 |
P00520 | Tyrosine-protein kinase ABL1 |
P56391 | Cytochrome c oxidase subunit 6B1 |
D3YXS5 | Kinesin-like protein KLP6 |
P12787 | Cytochrome c oxidase subunit 5A, mitochondrial |
Q05A80 | Caprin-2 |
Q149F5 | Transmembrane protein 71 |
Q9D8P4 | 39S ribosomal protein L17, mitochondrial |
P00015 | Cytochrome c, testis-specific |
Q9DAQ9 | Spermatogenesis-associated protein 19, mitochondrial |
Q8BX70 | Vacuolar protein sorting-associated protein 13C |
Q99MD6 | Thioredoxin reductase 3 (Fragment) |
Q60575 | Kinesin-like protein KIF1B |
Q6K1E7 | Gametogenetin-binding protein 1 |
Q8R4U6 | DNA topoisomerase I, mitochondrial |
Q99K67 | Alpha-aminoadipic semialdehyde synthase, mitochondrial |
Q924H5 | DNA repair protein RAD51 homolog 3 |
Q60930 | Voltage-dependent anion-selective channel protein 2 |
P11798 | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
Q8CAS9 | Poly [ADP-ribose] polymerase 9 |
Q9QZM2 | DNA polymerase subunit gamma-2, mitochondrial |
Q8CGY8 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
Q9CZW5 | Mitochondrial import receptor subunit TOM70 |
Q60855 | Receptor-interacting serine/threonine-protein kinase 1 |
Q62425 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 |
Q80Y44 | Probable ATP-dependent RNA helicase DDX10 |
Q925I1 | ATPase family AAA domain-containing protein 3 |
Q6ZWQ0 | Nesprin-2 |
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Kartawy, M.; Khaliulin, I.; Amal, H. Systems Biology Reveals S-Nitrosylation-Dependent Regulation of Mitochondrial Functions in Mice with Shank3 Mutation Associated with Autism Spectrum Disorder. Brain Sci. 2021, 11, 677. https://doi.org/10.3390/brainsci11060677
Kartawy M, Khaliulin I, Amal H. Systems Biology Reveals S-Nitrosylation-Dependent Regulation of Mitochondrial Functions in Mice with Shank3 Mutation Associated with Autism Spectrum Disorder. Brain Sciences. 2021; 11(6):677. https://doi.org/10.3390/brainsci11060677
Chicago/Turabian StyleKartawy, Maryam, Igor Khaliulin, and Haitham Amal. 2021. "Systems Biology Reveals S-Nitrosylation-Dependent Regulation of Mitochondrial Functions in Mice with Shank3 Mutation Associated with Autism Spectrum Disorder" Brain Sciences 11, no. 6: 677. https://doi.org/10.3390/brainsci11060677