Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia
1
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21210, USA
2
Department of Otolaryngology, Johns Hopkins Medicine, Baltimore, MD 21210, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Marangolo
Brain Sci. 2021, 11(3), 335; https://doi.org/10.3390/brainsci11030335
Received: 31 December 2020
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Revised: 1 March 2021
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Accepted: 3 March 2021
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Published: 6 March 2021
(This article belongs to the Special Issue New Perspectives and Methodologies in the Diagnosis and Rehabilitation of Aphasia)
Transcranial direct current stimulation (tDCS) over the left inferior frontal gyrus (IFG) was found to improve oral and written naming in post-stroke and primary progressive aphasia (PPA), speech fluency in stuttering, a developmental speech-motor disorder, and apraxia of speech (AOS) symptoms in post-stroke aphasia. This paper addressed the question of whether tDCS over the left IFG coupled with speech therapy may improve sound duration in patients with apraxia of speech (AOS) symptoms in non-fluent PPA (nfvPPA/AOS) more than sham. Eight patients with non-fluent PPA/AOS received either active or sham tDCS, along with speech therapy for 15 sessions. Speech therapy involved repeating words of increasing syllable-length. Evaluations took place before, immediately after, and two months post-intervention. Words were segmented into vowels and consonants and the duration of each vowel and consonant was measured. Segmental duration was significantly shorter after tDCS compared to sham and tDCS gains generalized to untrained words. The effects of tDCS sustained over two months post-treatment in trained and untrained sounds. Taken together, these results demonstrate that tDCS over the left IFG may facilitate speech production by reducing segmental duration. The results provide preliminary evidence that tDCS may maximize efficacy of speech therapy in patients with nfvPPA/AOS.
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Keywords:
apraxia of speech (AOS); transcranial direct current stimulation (tDCS); primary progressive aphasia (PPA); inferior frontal gyrus (IFG); sound duration; brain stimulation
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MDPI and ACS Style
Themistocleous, C.; Webster, K.; Tsapkini, K. Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia. Brain Sci. 2021, 11, 335. https://doi.org/10.3390/brainsci11030335
AMA Style
Themistocleous C, Webster K, Tsapkini K. Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia. Brain Sciences. 2021; 11(3):335. https://doi.org/10.3390/brainsci11030335
Chicago/Turabian StyleThemistocleous, Charalambos, Kimberly Webster, and Kyrana Tsapkini. 2021. "Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia" Brain Sciences 11, no. 3: 335. https://doi.org/10.3390/brainsci11030335
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