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Article

Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke

1
Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 05355, Korea
2
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, Korea
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Department of Neurology, Uijeongbu Eulji Medical Center, Eulji University College of Medicine, Uijeonbu-si 11759, Korea
4
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea
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Emergency Medical Center, Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea
6
Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul 03080, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Fabio Pilato
Brain Sci. 2021, 11(3), 337; https://doi.org/10.3390/brainsci11030337
Received: 28 January 2021 / Revised: 22 February 2021 / Accepted: 2 March 2021 / Published: 6 March 2021
Background: There is growing interest in the use of new biomarkers such as glycated albumin (GA), but data are limited in acute ischemic stroke. We explored the impact of GA on short-term functional outcomes as measured using the modified Rankin Scale (mRS) at 3 months compared to glycated hemoglobin (HbA1c). Methods: A total of 1163 AIS patients from two hospitals between 2016 and 2019 were included. Patients were divided into two groups according to GA levels (GA < 16% versus GA ≥ 16%). Results: A total of 518 patients (44.5%) were included in the GA ≥ 16% group. After adjusting for multiple covariates, the higher GA group (GA ≥ 16%) had a 1.4-fold risk of having unfavorable mRS (95% CI 1.02–1.847). However, HbA1c was not significantly associated with 3-month mRS. In addition, GA ≥ 16% was independently associated with unfavorable short-term outcomes only in patients without diabetes. Conclusions: In light of these results, GA level might be a novel prognostic biomarker compared to HbA1c for short-term stroke outcome. Although the impact of GA is undervalued in the current stroke guidelines, GA monitoring should be considered in addition to HbA1c monitoring. View Full-Text
Keywords: glycated albumin; glycated hemoglobin; brain ischemia; stroke; prognosis; biomarkers; blood glucose glycated albumin; glycated hemoglobin; brain ischemia; stroke; prognosis; biomarkers; blood glucose
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MDPI and ACS Style

Kim, Y.; Lee, S.-H.; Kang, M.K.; Kim, T.J.; Jeong, H.-Y.; Lee, E.-J.; Bae, J.; Jeon, K.; Nam, K.-W.; Yoon, B.-W. Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke. Brain Sci. 2021, 11, 337. https://doi.org/10.3390/brainsci11030337

AMA Style

Kim Y, Lee S-H, Kang MK, Kim TJ, Jeong H-Y, Lee E-J, Bae J, Jeon K, Nam K-W, Yoon B-W. Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke. Brain Sciences. 2021; 11(3):337. https://doi.org/10.3390/brainsci11030337

Chicago/Turabian Style

Kim, Yerim, Sang-Hwa Lee, Min K. Kang, Tae J. Kim, Han-Yeong Jeong, Eung-Joon Lee, Jeonghoon Bae, Kipyoung Jeon, Ki-Woong Nam, and Byung-Woo Yoon. 2021. "Glycated Albumin, a Novel Biomarker for Short-Term Functional Outcomes in Acute Ischemic Stroke" Brain Sciences 11, no. 3: 337. https://doi.org/10.3390/brainsci11030337

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