Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Image Data Acquisition
2.3. MRI Data Processing
2.4. Statistical Analysis
3. Results
3.1. Demographic and Neuropsychological Tests Results
3.2. VBM Results
3.3. ALFF Results
3.4. DC Results
3.5. Linear Regression Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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HC (N = 31) | VaMCI (N = 31) | p-Value | |
---|---|---|---|
Age (years) | 59.35 (8.15) | 62.87 (7.07) | 0.075 |
Gender (male/female) | 14/17 | 20/11 | 0.446 |
Education level (years) | 11(9, 12) | 9 (8, 11) | 0.017 |
MoCA score | 28 (26, 30) | 23(20, 24) | <0.001 |
HAMD score | 0 (0, 1) | 3 (0, 8) | 0.006 |
HAMA score | 0 (0, 3) | 3 (0, 6) | 0.009 |
Region | Cluster Size | MNI Coordinate | t-Value |
---|---|---|---|
(voxel) | (x, y, z) | ||
R.PCu | 258 | (15, −45, 45) | 5.05 |
R.AG | 125 | (54, −63, 45) | 4.91 |
R.medFG | 58 | (6, 39, 36) | 6.08 |
L.PCu | 44 | (−33, −81, 39) | 4.35 |
Region | Cluster Size | MNI Coordinate | t-Value |
---|---|---|---|
(voxel) | (x, y, z) | ||
L.AG | 258 | (−36, −60, 33) | 4.15 |
R.PCu | 224 | (6, −45, 42) | 4.24 |
R.AG | 220 | (42, −72, 48) | 4.69 |
Unstandardized Coefficient | Standardized Coefficient | t | p | |||
---|---|---|---|---|---|---|
B | SE(B) | β | ||||
MoCA | Constant | 23.528 | 0.488 | 48.193 | <0.001 *** | |
Age | −0.160 | −1.103 | 0.280 | |||
Gender | 0.006 | 0.042 | 0.967 | |||
Edu. level | 0.043 | 0.292 | 0.773 | |||
GMV | 0.092 | 0.627 | 0.536 | |||
ALFF | 2.122 | 0.489 | 0.627 | 4.338 | <0.001 *** | |
DC | −0.077 | −0.476 | 0.638 | |||
Registered R square: 0.373; ANOVA: <0.001 | ||||||
HAMA | Constant | 1.727 | 0.836 | 2.065 | 0.048 * | |
Age | 0.224 | 1.249 | 0.222 | |||
Gender | 2.773 | 1.041 | 0.443 | 2.663 | 0.013 * | |
Edu. level | 0.065 | 0.368 | 0.716 | |||
GMV | −0.323 | −2.043 | 0.051 | |||
ALFF | 0.050 | 0.292 | 0.773 | |||
DC | −0.237 | −1.349 | 0.188 | |||
Registered R square: 0.169; ANOVA: 0.013 | ||||||
HAMD | Constant | 0.220 | 1.104 | 0.199 | 0.844 | |
Age | 0.083 | 0.517 | 0.610 | |||
Gender | 2.963 | 1.251 | 0.322 | 2.368 | 0.025 * | |
Edu. level | −0.084 | −0.589 | 0.561 | |||
GMV | −3.426 | 0.735 | −0.633 | −4.662 | <0.001 *** | |
ALFF | −0.086 | −0.615 | 0.544 | |||
DC | −0.114 | −0.775 | 0.445 | |||
Registered R square: 0.448; ANOVA: <0.001 |
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Li, H.; Jia, X.; Li, Y.; Jia, X.; Yang, Q. Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment. Brain Sci. 2021, 11, 1534. https://doi.org/10.3390/brainsci11111534
Li H, Jia X, Li Y, Jia X, Yang Q. Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment. Brain Sciences. 2021; 11(11):1534. https://doi.org/10.3390/brainsci11111534
Chicago/Turabian StyleLi, Haoyuan, Xiuqin Jia, Yingying Li, Xuejia Jia, and Qi Yang. 2021. "Aberrant Amplitude of Low-Frequency Fluctuation and Degree Centrality within the Default Mode Network in Patients with Vascular Mild Cognitive Impairment" Brain Sciences 11, no. 11: 1534. https://doi.org/10.3390/brainsci11111534