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Recent Advances in Antigen-Specific Immunotherapies for the Treatment of Multiple Sclerosis
Review

Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System

Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece
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Brain Sci. 2020, 10(6), 338; https://doi.org/10.3390/brainsci10060338
Received: 4 May 2020 / Revised: 25 May 2020 / Accepted: 30 May 2020 / Published: 2 June 2020
(This article belongs to the Special Issue Advances in Multiple Sclerosis Research—Series I)
Multiple sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease of the central nervous system (CNS) that yields to neuronal axon damage, demyelization, and paralysis. Although several drugs were designed for the treatment of MS, with some of them being approved in the last few decades, the complete remission and the treatment of progressive forms still remain a matter of debate and a medical challenge. Nanotechnology provides a variety of promising therapeutic tools that can be applied for the treatment of MS, overcoming the barriers and the limitations of the already existing immunosuppressive and biological therapies. In the present review, we explore literature case studies on the development of drug delivery nanosystems for the targeted delivery of MS drugs in the pathological tissues of the CNS, providing high bioavailability and enhanced therapeutic efficiency, as well as nanosystems for the delivery of agents to facilitate efficient remyelination. Moreover, we present examples of tolerance-inducing nanocarriers, being used as promising vaccines for antigen-specific immunotherapy of MS. We emphasize on liposomes, as well as lipid- and polymer-based nanoparticles. Finally, we highlight the future perspectives given by the nanotechnology field toward the improvement of the current treatment of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). View Full-Text
Keywords: multiple sclerosis; nanotechnology; drug delivery nanosystems; lipids; polymers; vaccines; nanoparticles; antigen-specific immunotherapy; experimental autoimmune encephalomyelitis; neurodegeneration multiple sclerosis; nanotechnology; drug delivery nanosystems; lipids; polymers; vaccines; nanoparticles; antigen-specific immunotherapy; experimental autoimmune encephalomyelitis; neurodegeneration
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MDPI and ACS Style

Chountoulesi, M.; Demetzos, C. Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System. Brain Sci. 2020, 10, 338. https://doi.org/10.3390/brainsci10060338

AMA Style

Chountoulesi M, Demetzos C. Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System. Brain Sciences. 2020; 10(6):338. https://doi.org/10.3390/brainsci10060338

Chicago/Turabian Style

Chountoulesi, Maria, and Costas Demetzos. 2020. "Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System" Brain Sciences 10, no. 6: 338. https://doi.org/10.3390/brainsci10060338

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