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The Long Road of Immunotherapeutics against Multiple Sclerosis
Open AccessFeature PaperReview

Molecular Interventions towards Multiple Sclerosis Treatment

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Nikolaou Plastira 100, 70013 Heraklion, Greece
Department of Basic Sciences, Faculty of Medicine, University of Crete, 71110 Heraklion, Greece
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(5), 299;
Received: 28 April 2020 / Revised: 11 May 2020 / Accepted: 12 May 2020 / Published: 15 May 2020
(This article belongs to the Special Issue Advances in Multiple Sclerosis Research)
Multiple sclerosis (MS) is an autoimmune life-threatening disease, afflicting millions of people worldwide. Although the disease is non-curable, considerable therapeutic advances have been achieved through molecular immunotherapeutic approaches, such as peptides vaccination, administration of monoclonal antibodies, and immunogenic copolymers. The main aims of these therapeutic strategies are to shift the MS-related autoimmune response towards a non-inflammatory T helper 2 (Th2) cells response, inactivate or ameliorate cytotoxic autoreactive T cells, induce secretion of anti-inflammatory cytokines, and inhibit recruitment of autoreactive lymphocytes to the central nervous system (CNS). These approaches can efficiently treat autoimmune encephalomyelitis (EAE), an essential system to study MS in animals, but they can only partially inhibit disease progress in humans. Nevertheless, modern immunotherapeutic techniques remain the most promising tools for the development of safe MS treatments, specifically targeting the cellular factors that trigger the initiation of the disease. View Full-Text
Keywords: B cell receptor; delivery methods; immunotherapy; monoclonal antibodies; multiple sclerosis; T cell receptor; tolerance; vaccine B cell receptor; delivery methods; immunotherapy; monoclonal antibodies; multiple sclerosis; T cell receptor; tolerance; vaccine
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MDPI and ACS Style

Metaxakis, A.; Petratou, D.; Tavernarakis, N. Molecular Interventions towards Multiple Sclerosis Treatment. Brain Sci. 2020, 10, 299.

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