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Dopamine Receptor DRD2 Gene rs1076560, Personality Traits and Anxiety in the Polysubstance Use Disorder

Independent Laboratory of Health Promotion of the Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland
Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, Zyty 28 St., 65-046 Zielona Gora, Poland
Neurophysiological Independent Unit, Department of Psychiatry, Medical University of Lublin, 20-093 Lublin, Poland
Department of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University, 48 Żołnierska St., 71-210 Szczecin, Poland
Indywidual Medical Practice MD M Sznabowicz, Lutówko 14, 74-320 Barlinek, Poland
Faculty of Physical Education, University of Rzeszów, Towarnickiego 3 St., 35-959 Rzeszów, Poland
Faculty of Physical Culture, Gdańsk University of Physical Education and Sport, Kazimierza Górskiego 1 St., 80-336 Gdańsk, Poland
Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp. St., 70-111 Szczecin, Poland
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(5), 262;
Received: 16 April 2020 / Revised: 24 April 2020 / Accepted: 28 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue The Role of Dopamine in Neural Circuits)
Development of an addiction is conditioned by many factors. The dopaminergic system has been shown to be the key element in this process. In this paper, we analyzed the influence of dopamine receptor 2 polymorphism rs1076560 in two groups—polysubstance-dependent male patients (n = 299) and the controls matched for age (n = 301). In both groups, we applied the same questionnaires for testing—Mini-international neuropsychiatric interview, the NEO Five-Factor Inventory, and the State–Trait Anxiety Inventory. The real-time PCR method was used for genotyping. When we compared the controls with the case group subjects, we observed significantly higher scores in the second group on both the state and trait scales of anxiety, as well as on the Neuroticism and Openness scales of the NEO-FFI; and lower scores on the scales of Extraversion and Agreeability of the NEO-FFI. The model 2 × 3 factorial ANOVA of the addicted subjects and controls was performed, and the DRD2 rs1076560 variant interaction was found for the anxiety state and trait scales, and for the NEO-FFI Neuroticism scale. The observed associations allow noticing that analysis of psychological factors in combination with genetic data opens new possibilities in addiction research. View Full-Text
Keywords: addiction; dopamine; dependence; personality traits; genetics addiction; dopamine; dependence; personality traits; genetics
MDPI and ACS Style

Suchanecka, A.; Chmielowiec, J.; Chmielowiec, K.; Masiak, J.; Sipak-Szmigiel, O.; Sznabowicz, M.; Czarny, W.; Michałowska-Sawczyn, M.; Trybek, G.; Grzywacz, A. Dopamine Receptor DRD2 Gene rs1076560, Personality Traits and Anxiety in the Polysubstance Use Disorder. Brain Sci. 2020, 10, 262.

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