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Open AccessCase Report

Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies

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Pediatric Neurology and Nemo Clinical Centre, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
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Pediatric Neuropsichiatric Unit, ASL, 83100 Avellino, Italy
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Institute of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del sacro Cuore, 00168 Roma, Italy
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Pediatric Neurology, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
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Periodic Fevers Research Centre and rare disease. Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
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Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(3), 156; https://doi.org/10.3390/brainsci10030156
Received: 4 February 2020 / Revised: 3 March 2020 / Accepted: 5 March 2020 / Published: 7 March 2020
(This article belongs to the Special Issue Prevention and Intervention for Pediatric Brain Injury)
We report the clinical case of a nine-year-old girl who presented with progressive motor neuropathy, revealed via the detection of a higher delay in F-wave recording using digitalized nerve conduction/electromyography. Since the lupus anticoagulant (LAC) positivity, detected using diluted Russell viper venom time (dRVVT), switched to persistent serological anticardiolipin immunoglobulin G (IgG) positivity, a possible non-thrombotic antiphospholipid antibody (aPL)-related clinical manifestation was suspected, and intravenous immunoglobulin treatment (IVIG) was started. The IVIG treatment was well tolerated and the complete resolution of motor impairment was obtained after the third IVIG infusion. Our findings suggest that it could be useful to check for antiphospholipid antibodies in children with a rapid onset of progressive neurological signs in order to provide the beneficial use of IVIG in the treatment of pediatric aPL neurological conditions. View Full-Text
Keywords: antiphospholipid antibodies; pediatric motor neuropathy; IVIG antiphospholipid antibodies; pediatric motor neuropathy; IVIG
MDPI and ACS Style

Brogna, C.; Luigetti, M.; Norcia, G.; Scalise, R.; Ferrantini, G.; Berti, B.; Romeo, D.M.; Manna, R.; Mercuri, E.; Pane, M. Pediatric Motor Inflammatory Neuropathy: The Role of Antiphospholipid Antibodies. Brain Sci. 2020, 10, 156.

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