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Review

Tau and DNA Damage in Neurodegeneration

by
Luca Colnaghi
1,*,
Diego Rondelli
2,
Marco Muzi-Falconi
2 and
Sarah Sertic
2,*
1
Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Negri 2, 20156 Milan, Italy
2
Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy
*
Authors to whom correspondence should be addressed.
Brain Sci. 2020, 10(12), 946; https://doi.org/10.3390/brainsci10120946
Submission received: 16 October 2020 / Revised: 29 November 2020 / Accepted: 2 December 2020 / Published: 7 December 2020
(This article belongs to the Special Issue Old and New Insights into the Role of Tau in Neurodegeneration)
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Abstract

Neurodegenerative disorders are a family of incurable conditions. Among them, Alzheimer’s disease and tauopathies are the most common. Pathological features of these two disorders are synaptic loss, neuronal cell death and increased DNA damage. A key pathological protein for the onset and progression of the conditions is the protein tau, a microtubule-binding protein highly expressed in neurons and encoded by the MAPT (microtubule-associated protein tau) gene. Tau is predominantly a cytosolic protein that interacts with numerous other proteins and molecules. Recent findings, however, have highlighted new and unexpected roles for tau in the nucleus of neuronal cells. This review summarizes the functions of tau in the metabolism of DNA, describing them in the context of the disorders.
Keywords: tau; DNA damage; Alzheimer’s disease tau; DNA damage; Alzheimer’s disease

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MDPI and ACS Style

Colnaghi, L.; Rondelli, D.; Muzi-Falconi, M.; Sertic, S. Tau and DNA Damage in Neurodegeneration. Brain Sci. 2020, 10, 946. https://doi.org/10.3390/brainsci10120946

AMA Style

Colnaghi L, Rondelli D, Muzi-Falconi M, Sertic S. Tau and DNA Damage in Neurodegeneration. Brain Sciences. 2020; 10(12):946. https://doi.org/10.3390/brainsci10120946

Chicago/Turabian Style

Colnaghi, Luca, Diego Rondelli, Marco Muzi-Falconi, and Sarah Sertic. 2020. "Tau and DNA Damage in Neurodegeneration" Brain Sciences 10, no. 12: 946. https://doi.org/10.3390/brainsci10120946

APA Style

Colnaghi, L., Rondelli, D., Muzi-Falconi, M., & Sertic, S. (2020). Tau and DNA Damage in Neurodegeneration. Brain Sciences, 10(12), 946. https://doi.org/10.3390/brainsci10120946

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