Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review
1
Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany
2
Faculty of Medicine and Health Sciences, University of Zielona Gora, 65-046 Zielona Gora, Poland
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(12), 901; https://doi.org/10.3390/brainsci10120901
Received: 20 October 2020
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Revised: 16 November 2020
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Accepted: 21 November 2020
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Published: 24 November 2020
(This article belongs to the Special Issue Tinnitus Subtyping)
Tinnitus is a subjective phantom sound perceived only by the affected person and a symptom of various auditory and non-auditory conditions. The majority of methods used in clinical and basic research for tinnitus diagnosis are subjective. To better understand tinnitus-associated changes in the auditory system, an objective technique measuring auditory sensitivity—the auditory brainstem responses (ABR)—has been suggested. Therefore, the present review aimed to summarize ABR’s features in a rat model during experimentally induced tinnitus. PubMed, Web of Science, Science Direct, and Scopus databanks were searched using Medical Subject Heading (MeSH) terms: auditory brainstem response, tinnitus, rat. The search identified 344 articles, and 36 of them were selected for the full-text analyses. The experimental protocols and results were evaluated, and the gained knowledge was synthesized. A high level of heterogeneity between the studies was found regarding all assessed areas. The most consistent finding of all studies was a reduction in the ABR wave I amplitude following exposure to noise and salicylate. Simultaneously, animals with salicylate-induced but not noise-induced tinnitus had an increased amplitude of wave IV. Furthermore, the present study identified a need to develop a consensus experimental ABR protocol applied in future tinnitus studies using the rat model.
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Keywords:
auditory brainstem response (ABR); tinnitus; animal model; rat
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MDPI and ACS Style
Domarecka, E.; Olze, H.; Szczepek, A.J. Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review. Brain Sci. 2020, 10, 901. https://doi.org/10.3390/brainsci10120901
AMA Style
Domarecka E, Olze H, Szczepek AJ. Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review. Brain Sciences. 2020; 10(12):901. https://doi.org/10.3390/brainsci10120901
Chicago/Turabian StyleDomarecka, Ewa, Heidi Olze, and Agnieszka J. Szczepek 2020. "Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review" Brain Sciences 10, no. 12: 901. https://doi.org/10.3390/brainsci10120901
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