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Article

The Prognostic Role of Lactate Concentrations after Aneurysmal Subarachnoid Hemorrhage

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Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik, 808 1070 Brussels, Belgium
2
Department of Neurosurgery, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik, 808 1070 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(12), 1004; https://doi.org/10.3390/brainsci10121004
Received: 10 November 2020 / Revised: 4 December 2020 / Accepted: 16 December 2020 / Published: 17 December 2020
Blood lactate concentrations are often used to assess global tissue perfusion in critically ill patients; however, there are scarce data on lactate concentrations after subarachnoid hemorrhage (SAH). We aimed to assess the prognostic role of serial blood lactate measurements on hospital mortality and neurological outcomes at 3 months after SAH. We reviewed all SAH patients admitted to the intensive care unit from 2007 to 2019 and recorded the highest daily arterial lactate concentration for the first 6 days. Patients with no lactate concentration were excluded. Hyperlactatemia was defined as a blood lactate concentration >2.0 mmol/L. A total of 456 patients were included: 158 (35%) patients died in hospital and 209 (46%) had an unfavorable outcome (UO) at 3 months. The median highest lactate concentration was 2.7 (1.8–3.9) mmol/L. Non-survivors and patients with UO had significantly higher lactate concentrations compared to other patients. Hyperlactatemia increased the chance of dying (OR 4.19 (95% CI 2.38–7.39)) and of having UO in 3 months (OR 4.16 (95% CI 2.52–6.88)) after adjusting for confounding factors. Therefore, initial blood lactate concentrations have prognostic implications in patients with SAH; their role in conjunction with other prognostic indicators should be evaluated in prospective studies. View Full-Text
Keywords: lactate; glucose; subarachnoid hemorrhage; prognosis; biomarkers; Glasgow outcome scale; mortality lactate; glucose; subarachnoid hemorrhage; prognosis; biomarkers; Glasgow outcome scale; mortality
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MDPI and ACS Style

Ndieugnou Djangang, N.; Ramunno, P.; Izzi, A.; Garufi, A.; Menozzi, M.; Diaferia, D.; Peluso, L.; Prezioso, C.; Talamonti, M.; Njimi, H.; Schuind, S.; Vincent, J.-L.; Creteur, J.; Taccone, F.S.; Gouvea Bogossian, E. The Prognostic Role of Lactate Concentrations after Aneurysmal Subarachnoid Hemorrhage. Brain Sci. 2020, 10, 1004. https://doi.org/10.3390/brainsci10121004

AMA Style

Ndieugnou Djangang N, Ramunno P, Izzi A, Garufi A, Menozzi M, Diaferia D, Peluso L, Prezioso C, Talamonti M, Njimi H, Schuind S, Vincent J-L, Creteur J, Taccone FS, Gouvea Bogossian E. The Prognostic Role of Lactate Concentrations after Aneurysmal Subarachnoid Hemorrhage. Brain Sciences. 2020; 10(12):1004. https://doi.org/10.3390/brainsci10121004

Chicago/Turabian Style

Ndieugnou Djangang, Narcisse, Pamela Ramunno, Antonio Izzi, Alessandra Garufi, Marco Menozzi, Daniela Diaferia, Lorenzo Peluso, Chiara Prezioso, Marta Talamonti, Hassane Njimi, Sophie Schuind, Jean-Louis Vincent, Jacques Creteur, Fabio S. Taccone, and Elisa Gouvea Bogossian. 2020. "The Prognostic Role of Lactate Concentrations after Aneurysmal Subarachnoid Hemorrhage" Brain Sciences 10, no. 12: 1004. https://doi.org/10.3390/brainsci10121004

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