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Open AccessArticle

Improvements of Motor Performances in the Drosophila LRRK2 Loss-of-Function Model of Parkinson’s Disease: Effects of Dialyzed Leucocyte Extracts from Human Serum

1
Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy
2
CNR Institute of Translational Pharmacology, 09010 Pula/Cagliari, Italy
3
National School of Biological Sciences, IPN, Mexico City 07738, Mexico
*
Authors to whom correspondence should be addressed.
Brain Sci. 2020, 10(1), 45; https://doi.org/10.3390/brainsci10010045
Received: 7 December 2019 / Revised: 5 January 2020 / Accepted: 9 January 2020 / Published: 14 January 2020
(This article belongs to the Section Molecular and Cellular Neuroscience)
Within neurodegenerative syndromes, Parkinson’s disease (PD) is typically associated with its locomotor defects, sleep disturbances and related dopaminergic (DA) neuron loss. The fruit fly, Drosophila melanogaster (D. melanogaster), with leucine-rich repeat kinase 2 mutants (LRRK2) loss-of-function in the WD40 domain, provides mechanistic insights into corresponding human behaviour, possibly disclosing some physiopathologic features of PD in both genetic and sporadic forms. Moreover, several data support the boosting impact of innate and adaptive immunity pathways for driving the progression of PD. In this context, human dialyzable leukocyte extracts (DLE) have been extensively used to transfer antigen-specific information that influences the activity of various immune components, including inflammatory cytokines. Hence, the main goal of our study was to ascertain the therapeutic potential of DLE from male and female donors on D. melanogaster LRRK2 loss-of-function, as compared to D. melanogaster wild-type (WT), in terms of rescuing physiological parameters, such as motor and climbing activities, which are severely compromised in the mutant flies. Finally, in search of the anatomical structures responsible for restored functions in parkinsonian-like mutant flies, we found a topographical correlation between improvement of locomotor performances and an increased number of dopaminergic neurons in selective areas of LRRK2 mutant brains. View Full-Text
Keywords: Drosophila melanogaster; LRRK2 loss-of-function; Parkinson’s disease; motor functions; human dialyzed leukocyte extract Drosophila melanogaster; LRRK2 loss-of-function; Parkinson’s disease; motor functions; human dialyzed leukocyte extract
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Diana, A.; Collu, M.; Casu, M.A.; Mocci, I.; Aguilar-Santelises, M.; Setzu, M.D. Improvements of Motor Performances in the Drosophila LRRK2 Loss-of-Function Model of Parkinson’s Disease: Effects of Dialyzed Leucocyte Extracts from Human Serum. Brain Sci. 2020, 10, 45.

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