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Article

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

1
Institute for Materials Science and Max Bergmann Center of Biomaterials, Technische Universität Dresden, 01062 Dresden, Germany
2
Fraunhofer Institute for Ceramic Technologies and Systems IKTS Material Diagnostics, 01109 Dresden and 04103 Leipzig, Germany
3
Physical Chemistry, Technische Universität Dresden, 01062 Dresden, Germany
4
Dresden Center for Computational Materials Science, Technische Universität Dresden, 01062 Dresden, Germany
5
Center for Advancing Electronics Dresden, Technische Universität Dresden, 01062 Dresden, Germany
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(6), 1064; https://doi.org/10.3390/app9061064
Received: 31 January 2019 / Revised: 4 March 2019 / Accepted: 5 March 2019 / Published: 13 March 2019
(This article belongs to the Special Issue Biocompatible Materials)
Detonation nanodiamonds (NDs) are a novel class of carbon-based nanomaterials, and have received a great deal of attention in biomedical applications, due to their high biocompatibility, facile surface functionalization, and commercialized synthetic fabrication. We were able to transfer the NDs from large-size agglomerate suspensions to homogenous coatings. ND suspensions have been used in various techniques to coat on commercially available substrates of pure Ti and Si. Scanning electron microscopy (SEM) imaging and nanoindentation show that the densest and strongest coating of NDs was generated when using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide (EDC/NHS)-mediated coupling to macroscopic silanized surfaces. In the next step, the feasibility of DNA-mediated coupling of NDs on macroscopic surfaces is discussed using fluorescent microscopy and additional particle size distribution, as well as zeta potential measurements. This work compares different ND coating strategies and describes the straightforward technique of grafting single-stranded DNA onto carboxylated NDs via thioester bridges. View Full-Text
Keywords: detonation nanodiamonds; bio-conjugation; de-agglomeration; fluorescent microscopy; nanoindentation detonation nanodiamonds; bio-conjugation; de-agglomeration; fluorescent microscopy; nanoindentation
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MDPI and ACS Style

Balakin, S.; Dennison, N.R.; Klemmed, B.; Spohn, J.; Cuniberti, G.; Römhildt, L.; Opitz, J. Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces. Appl. Sci. 2019, 9, 1064. https://doi.org/10.3390/app9061064

AMA Style

Balakin S, Dennison NR, Klemmed B, Spohn J, Cuniberti G, Römhildt L, Opitz J. Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces. Applied Sciences. 2019; 9(6):1064. https://doi.org/10.3390/app9061064

Chicago/Turabian Style

Balakin, Sascha, Nicholas R. Dennison, Benjamin Klemmed, Juliane Spohn, Gianaurelio Cuniberti, Lotta Römhildt, and Jörg Opitz. 2019. "Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces" Applied Sciences 9, no. 6: 1064. https://doi.org/10.3390/app9061064

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