Next Article in Journal
In Vivo Experimental Study on the Enhancement of Optical Clearing Effect by Laser Irradiation in Conjunction with a Chemical Penetration Enhancer
Previous Article in Journal
Microstructural Investigations of Low Temperature Joining of Q&P Steels Using Ag Nanoparticles in Combination with Sn and SnAg as Activating Material
Article Menu
Issue 3 (February-1) cover image

Export Article

Open AccessFeature PaperArticle

Sensitivity Analysis of a Numerical Model for Percutaneous Auricular Vagus Nerve Stimulation

1
Department of Information Technology Ghent University/imec, Ghent 9052, Belgium
2
Research Group Biomedical Sensing, Institute of Electrodynamics, Microwave and Circuit Engineering, TU Wien, Vienna 1040, Austria
3
Department of Surgery, Medical University Vienna, Vienna 1090, Austria
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(3), 540; https://doi.org/10.3390/app9030540
Received: 7 January 2019 / Revised: 29 January 2019 / Accepted: 1 February 2019 / Published: 6 February 2019
(This article belongs to the Section Applied Biosciences and Bioengineering)
  |  
PDF [4933 KB, uploaded 6 February 2019]
  |  

Abstract

Background: Less-invasive percutaneous stimulation of the auricular branch of the vagus nerve (pVNS) gained importance as a possible nonpharmacological treatment for various diseases. The objective is to perform a sensitivity analysis of a realistic numerical model of pVNS and to investigate the effects of the model parameters on the excitation threshold for single and bundled axons. Methods: Sim4Life electrostatic solver and neural tissue models were combined for electromagnetic and neural simulation. The numerical model consisted of a high-resolution model of a human ear, blood vessels, nerves, and three needle electrodes. Investigated parameters include the axon diameter and number, model temperature, ear conductivity, and electrodes’ penetration depth and position. Results: The electric field distribution was evaluated. Model temperature and ear conductivity are the non-influential parameters. Axons fiber diameter and the electrodes’ penetration depth are the most influential parameters with a maximum threshold voltage sensitivity of 32 mV for each 1 μm change in the axon diameter and 38 mV for each 0.1 mm change in the electrodes’ penetration depth. Conclusions: The established sensitivity analysis allows the identification of the influential and the non-influential parameters with a sensitivity quantification. Results suggest that the electrodes’ penetration depth is the most influential parameter. View Full-Text
Keywords: sensitivity analysis; auricular branch of the vagus nerve; neuromodulation; SENN; electromagnetic simulation sensitivity analysis; auricular branch of the vagus nerve; neuromodulation; SENN; electromagnetic simulation
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Samoudi, A.M.; Kampusch, S.; Tanghe, E.; Széles, J.C.; Martens, L.; Kaniusas, E.; Joseph, W. Sensitivity Analysis of a Numerical Model for Percutaneous Auricular Vagus Nerve Stimulation. Appl. Sci. 2019, 9, 540.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Appl. Sci. EISSN 2076-3417 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top