Sensitivity Analysis of a Numerical Model for Percutaneous Auricular Vagus Nerve Stimulation
AbstractBackground: Less-invasive percutaneous stimulation of the auricular branch of the vagus nerve (pVNS) gained importance as a possible nonpharmacological treatment for various diseases. The objective is to perform a sensitivity analysis of a realistic numerical model of pVNS and to investigate the effects of the model parameters on the excitation threshold for single and bundled axons. Methods: Sim4Life electrostatic solver and neural tissue models were combined for electromagnetic and neural simulation. The numerical model consisted of a high-resolution model of a human ear, blood vessels, nerves, and three needle electrodes. Investigated parameters include the axon diameter and number, model temperature, ear conductivity, and electrodes’ penetration depth and position. Results: The electric field distribution was evaluated. Model temperature and ear conductivity are the non-influential parameters. Axons fiber diameter and the electrodes’ penetration depth are the most influential parameters with a maximum threshold voltage sensitivity of 32 mV for each 1 μm change in the axon diameter and 38 mV for each 0.1 mm change in the electrodes’ penetration depth. Conclusions: The established sensitivity analysis allows the identification of the influential and the non-influential parameters with a sensitivity quantification. Results suggest that the electrodes’ penetration depth is the most influential parameter. View Full-Text
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Samoudi, A.M.; Kampusch, S.; Tanghe, E.; Széles, J.C.; Martens, L.; Kaniusas, E.; Joseph, W. Sensitivity Analysis of a Numerical Model for Percutaneous Auricular Vagus Nerve Stimulation. Appl. Sci. 2019, 9, 540.
Samoudi AM, Kampusch S, Tanghe E, Széles JC, Martens L, Kaniusas E, Joseph W. Sensitivity Analysis of a Numerical Model for Percutaneous Auricular Vagus Nerve Stimulation. Applied Sciences. 2019; 9(3):540.Chicago/Turabian Style
Samoudi, Amine M.; Kampusch, Stefan; Tanghe, Emmeric; Széles, Jozsef C.; Martens, Luc; Kaniusas, Eugenijus; Joseph, Wout. 2019. "Sensitivity Analysis of a Numerical Model for Percutaneous Auricular Vagus Nerve Stimulation." Appl. Sci. 9, no. 3: 540.
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