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Open AccessArticle

Retinal Nerve Fiber Layer in Patients with Alcohol Use Disorder

1
Department of Psychiatry, Hospital Universitario Doce de Octubre, 28041 Madrid, Spain
2
Faculty of Optics and Optometry, Complutense University, 28040 Madrid, Spain
3
Centro Óptico Montero, 28032 Madrid, Spain
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Hospital Doce de Octubre Research Institute (i+12), 28041 Madrid, Spain
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Faculty of Health Sciences, University Camilo José Cela, 28692 Madrid, Spain
6
Thematic Network for Cooperative Health Research (RETICS), Addictive Disorders Network, Health Institute Carlos III, MICINN and FEDER, 28029 Madrid, Spain
7
Portucalense Institute of Neuropsychology and Cognitive and Behavioural Neurosciences (INPP), Portucalense University, 4200072 Porto, Portugal
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(24), 5331; https://doi.org/10.3390/app9245331
Received: 1 October 2019 / Revised: 1 December 2019 / Accepted: 2 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Optics and the Brain)
The objectives of the present study are to determine the effects of alcohol use on the retinal nerve fiber layer (RNFL) thickness and macular thickness of abstinent patients with alcohol use disorders (AUD) and to assess whether it correlates with alcohol consumption and/or cognitive impairment. This was a prospective, observational study that included 21 patients (42 eyes) and 21 controls (42 eyes). Patients met the criteria for early remission AUD at the moment of inclusion. We used optical coherence tomography to assess retinal thickness. Macular thickness in the group of AUD patients was lower in all quadrants (p < 0.05), with the exception of the peripheral and central. Regarding the nerve fiber layer in the macular and papilla areas, we found no significant differences. At the retina ganglion cell layer and in the nerve fiber of the macula, we found significant differences in all quadrants (p < 0.05), with the exception of the superior and superior nasal area, for the right eye. For the left eye, the only differences were found in the lower quadrant. Finally, when comparing the AUD patients to the controls, we found significant reductions in the ganglion cell layer of the macula in all quadrants in the former. There was a significant correlation between these findings and cognitive impairment (measured with the Test de Detección de Deterioro Cognitivo en Alcoholismo (TEDCA)), but not with alcohol consumption. Alcohol consumption is correlated with retinal harm and related cognitive decline. View Full-Text
Keywords: retina; alcohol; optical coherence tomography; mental disorder retina; alcohol; optical coherence tomography; mental disorder
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Álvarez-Sesmero, S.; Povedano-Montero, F.J.; Arias-Horcajadas, F.; Marín-Mayor, M.; Navarrete-Chamorro, P.; Raga-Martínez, I.; Rubio, G.; López-Muñoz, F. Retinal Nerve Fiber Layer in Patients with Alcohol Use Disorder. Appl. Sci. 2019, 9, 5331.

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