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Article
Peer-Review Record

Frequency and Intensity of Electrical Stimulation of Human Sympathetic Ganglia Affect Heart Rate Variability and Pain Threshold

Appl. Sci. 2019, 9(21), 4490; https://doi.org/10.3390/app9214490
by Sung-Hyoun Cho
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Appl. Sci. 2019, 9(21), 4490; https://doi.org/10.3390/app9214490
Submission received: 14 October 2019 / Revised: 20 October 2019 / Accepted: 22 October 2019 / Published: 23 October 2019

Round 1

Reviewer 1 Report

The authors have addressed all of my concerns adequately. No further comments.

Author Response

I attached response file.

Author Response File: Author Response.docx

Reviewer 2 Report

Study of 45 patients receiving HF-LI, LF-HI, or HF-HI electrical stimulation at T1-T4 sympathetic ganglia on HRV and pain threshold. Reasonable study. Should clearly state effects of frequency and intensity of HRV in the abstract by intervention (rather than "significant interaction between group A and group B").  Should provide premise and next steps for using results for practical application. Were results transient or persistent, and how long did they last? 

Author Response

I attached response file.

Author Response File: Author Response.docx

This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.


Round 1

Reviewer 1 Report

This study is well conducted and the manuscript reads well overall. I only have a couple of comments:

1) The limitations of the study should be discussed further in "Discussion".

2) A couple of important reviews on the role of the sympathetic nervous system in heart physiology and disease should be cited and mentioned in "Introduction": Eur J Pharmacol. 2015;763:143-8; Circ Res. 2013;113:739-53.

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