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Effects of an Acetic Acid and Acetone Mixture on the Characteristics and Scaffold–Cell Interaction of Electrospun Polycaprolactone Membranes

1
Tissue Engineering and Regenerative Medicine Laboratory, School of Biomedical Engineering, International University, Vietnam National University, Ho Chi Minh City 700000, Vietnam
2
Faculty of Materials Science and Technology, University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam
3
Center for Innovative Materials and Architectures, Vietnam National University, Ho Chi Minh City 700000, Vietnam
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(20), 4350; https://doi.org/10.3390/app9204350
Received: 13 September 2019 / Revised: 3 October 2019 / Accepted: 5 October 2019 / Published: 16 October 2019
(This article belongs to the Special Issue Biomaterials and Biofabrication)
Green electrospinning has attracted great interest since non-toxic solvents were shown to be applicable in the fabrication of fibrous materials while ensuring health safety and environmental protection. Less harmful reagents such as acetone (AC) and acetic acid (AA) have been employed in this field in recent years. However, research in this area is still rare, yielding only preliminary results. In this study, two different types of solvents (pure AC and an AA/AC mixture) were used to fabricate electrospun polycaprolactone (PCL) membranes. Sample morphology, wettability, tensile strength, and chemical composition were compared between two types of membranes. Cell–scaffold interaction was also examined by cell adhesion and proliferation assays. The results demonstrate that the two types of solvents had significant effects on membrane morphology, physical strength, and cell adherence behaviors, which should be considered for different application purposes. View Full-Text
Keywords: electrospinning; polycaprolactone; acetone; acetic acid; cell adhesion; cell proliferation electrospinning; polycaprolactone; acetone; acetic acid; cell adhesion; cell proliferation
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MDPI and ACS Style

Ho, M.H.; Do, T.B.-T.; Dang, N.N.-T.; Le, A.N.-M.; Ta, H.T.-K.; Vo, T.V.; Nguyen, H.T. Effects of an Acetic Acid and Acetone Mixture on the Characteristics and Scaffold–Cell Interaction of Electrospun Polycaprolactone Membranes. Appl. Sci. 2019, 9, 4350. https://doi.org/10.3390/app9204350

AMA Style

Ho MH, Do TB-T, Dang NN-T, Le AN-M, Ta HT-K, Vo TV, Nguyen HT. Effects of an Acetic Acid and Acetone Mixture on the Characteristics and Scaffold–Cell Interaction of Electrospun Polycaprolactone Membranes. Applied Sciences. 2019; 9(20):4350. https://doi.org/10.3390/app9204350

Chicago/Turabian Style

Ho, Minh H.; Do, Thien B.-T.; Dang, Nhi N.-T.; Le, An N.-M.; Ta, Hanh T.-K.; Vo, Toi V.; Nguyen, Hiep T. 2019. "Effects of an Acetic Acid and Acetone Mixture on the Characteristics and Scaffold–Cell Interaction of Electrospun Polycaprolactone Membranes" Appl. Sci. 9, no. 20: 4350. https://doi.org/10.3390/app9204350

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