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Open AccessArticle

Mechanochemical-Assisted Extraction and Pharmacological Study of Triterpenoids from Antrodia Camphorata

1
Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310032, China
2
Zhejiang Suichang Limin Pharmaceutical Co., Ltd., Suichang 323300, China
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(20), 4281; https://doi.org/10.3390/app9204281
Received: 9 September 2019 / Revised: 30 September 2019 / Accepted: 3 October 2019 / Published: 12 October 2019
(This article belongs to the Section Food Science and Technology)
Antrodia camphorata (AC) is a precious medicinal mushroom native to Taiwan and famous for its excellent pharmacological activity. A ball mill assisted mechanochemical extraction method was applied in the extraction of triterpenoids from Antrodia camphorata. Compared with the ethanol hot thermal reflux method, mechanochemical-assisted extraction afforded an increased yield of triterpenoids to 1.82 ± 0.04% under conditions of mixing with 10 WT% NaHCO3, milling for 20 min, and extracting with water and chloroform. Triterpenoids from Antrodia camphorata extracted by the mechanochemical-assisted extraction method (TAEM) resulted in stronger pharmacological activity as compared to that extracted by ethanol (TAEE). HPLC and LC-MS/MS results showed that the mechanochemical method could extract triterpenoids which were barely extracted by ethanol extraction. The results of this study could provide valuable ideas and a basis for the application of the mechanochemical-assisted extraction method in the extraction of triterpenoids from AC. View Full-Text
Keywords: Antrodia camphorata; triterpenoids; ball mill; mechanochemical-assisted extraction; pharmacological activity Antrodia camphorata; triterpenoids; ball mill; mechanochemical-assisted extraction; pharmacological activity
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He, R.; Wu, K.; Zhang, A.; Xie, Z.; Sun, P. Mechanochemical-Assisted Extraction and Pharmacological Study of Triterpenoids from Antrodia Camphorata. Appl. Sci. 2019, 9, 4281.

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