Next Article in Journal
Modeling of Atmospheric Pollution in Urban and Rural Sites Using a Probabilistic and Objective Approach
Next Article in Special Issue
Dependence-Analysis-Based Data-Refinement in Optical Scatterometry for Fast Nanostructure Reconstruction
Previous Article in Journal
Developing Project Managers’ Transversal Competences Using Building Information Modeling
Previous Article in Special Issue
Topological Charge Detection Using Generalized Contour-Sum Method from Distorted Donut-Shaped Optical Vortex Beams: Experimental Comparison of Closed Path Determination Methods
Open AccessArticle

A Mesh-Based Monte Carlo Study for Investigating Structural and Functional Imaging of Brain Tissue Using Optical Coherence Tomography

State Key Laboratory of Precision Measurement Technology & Instruments, Department of Precision Instrument, Tsinghua University, Beijing 100084, China
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(19), 4008; https://doi.org/10.3390/app9194008
Received: 12 August 2019 / Revised: 12 September 2019 / Accepted: 19 September 2019 / Published: 25 September 2019
Optical coherence tomography (OCT) can obtain high-resolution three-dimensional (3D) structural images of biological tissues, and spectroscopic OCT, which is one of the functional extensions of OCT, can also quantify chromophores of tissues. Due to its unique features, OCT has been increasingly used for brain imaging. To support the development of the simulation and analysis tools on which OCT-based brain imaging depends, a model of mesh-based Monte Carlo for OCT (MMC-OCT) is presented in this work to study OCT signals reflecting the structural and functional activities of brain tissue. In addition, an approach to improve the quantitative accuracy of chromophores in tissue is proposed and validated by MMC-OCT simulations. Specifically, the OCT-based brain structural imaging was first simulated to illustrate and validate the MMC-OCT strategy. We then focused on the influences of different wavelengths on the measurement of hemoglobin concentration C, oxygen saturation Y, and scattering coefficient S in brain tissue. Finally, it is proposed and verified here that the measurement accuracy of C, Y, and S can be improved by selecting appropriate wavelengths for calculation, which contributes to the experimental study of brain functional sensing. View Full-Text
Keywords: optical coherence tomography; Monte Carlo simulation; structural imaging; functional sensing optical coherence tomography; Monte Carlo simulation; structural imaging; functional sensing
Show Figures

Figure 1

MDPI and ACS Style

Yi, L.; Sun, L.; Zou, M.; Hou, B. A Mesh-Based Monte Carlo Study for Investigating Structural and Functional Imaging of Brain Tissue Using Optical Coherence Tomography. Appl. Sci. 2019, 9, 4008.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop