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Explanation of Osteoblastic Differentiation of Stem Cells by Photo Biomodulation Using the Resonant Recognition Model

1
AMALNA Consulting, Black Rock, Melbourne, VIC 3193, Australia
2
College of Science, Engineering and Health, RMIT University, Melbourne, VIC 3000, Australia
3
Tithon Biotech Inc., San Diego, CA 92127, USA
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(10), 1979; https://doi.org/10.3390/app9101979
Received: 14 April 2019 / Revised: 28 April 2019 / Accepted: 9 May 2019 / Published: 15 May 2019
(This article belongs to the Special Issue Novel Methods for Investigating Biomolecular Interactions)
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Abstract

Differentiation of stem cells into different tissues is a promising approach to treat a large number of diseases, as well as for tissue transplantation and repair. It has been shown that parathyroid hormone, similarly to stromal self-derived factor, and the radiation of specific electromagnetic frequencies of blue and green light, can encourage stem cell differentiation into osteoblasts. Here, we analysed parathyroid hormone, its receptor and stromal self-derived factor using the Resonant Recognition Model, which proposes that protein function is based on specific frequencies of electromagnetic radiation within ultra-violet, visible, infra-red and far infra-red light. The purpose of this research is to predict the characteristic frequencies related to parathyroid hormone activities, particularly differentiation of stem cells into osteoblasts. We have found that the most effective wavelength for stem cell differentiation would be 502 nm, which is between 420 nm and 540 nm, already experimentally proven to be effective in stimulating osteoblast differentiation. Thus, we propose that wavelength radiation of 502 nm will be even more efficient for differentiation of stem cells into osteoblasts. View Full-Text
Keywords: osteoblasts; stem cells; cell differentiation; parathyroid hormone; stromal self-derived factor; electromagnetic radiation; Resonant Recognition Model osteoblasts; stem cells; cell differentiation; parathyroid hormone; stromal self-derived factor; electromagnetic radiation; Resonant Recognition Model
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Cosic, I.; Paspaliaris, V.; Cosic, D. Explanation of Osteoblastic Differentiation of Stem Cells by Photo Biomodulation Using the Resonant Recognition Model. Appl. Sci. 2019, 9, 1979.

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