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Appl. Sci. 2017, 7(8), 785;

An Efficient Synthesis of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Department of Chemistry, Faculty of Dentistry, October University for Modern Science & Arts, Giza 12613, Egypt
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Authors to whom correspondence should be addressed.
Received: 22 July 2017 / Revised: 28 July 2017 / Accepted: 31 July 2017 / Published: 3 August 2017
(This article belongs to the Section Chemistry)
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A new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl-1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or ethyl acetoacetate and an excess of ammonium acetate under reflux in acetic acid. Similarly, two novel bipyridine derivatives were prepared by the above reaction using terephthaldehyde in lieu of benzaldehyde derivatives. In addition, a series of 1,2,4-triazolo[4,3-a]pyrimidines was synthesized by a reaction of 6-(pyrazol-3-yl)pyrimidine-2-thione with a number of hydrazonoyl chlorides in dioxane and in the presence of triethylamine. The structure of the produced compounds was established by elemental analyses and spectral methods, and the mechanisms of their formation was discussed. Furthermore, the pyrazolyl-pyridine derivatives were tested as anticancer agents and the results obtained showed that some of them revealed high activity against human hepatocellular carcinoma (HEPG2) cell lines. View Full-Text
Keywords: pyrazoles; pyridines; multicomponent reactions; pyrazolyl-pyridines; antitumor activity pyrazoles; pyridines; multicomponent reactions; pyrazolyl-pyridines; antitumor activity

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Abdallah, M.A.; Gomha, S.M.; Abbas, I.M.; Kazem, M.S.H.; Alterary, S.S.; Mabkhot, Y.N. An Efficient Synthesis of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents. Appl. Sci. 2017, 7, 785.

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