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Open AccessCommunication

Magnetic-Responsive Microparticles that Switch Shape at 37 °C

by Koichiro Uto 1 and Mitsuhiro Ebara 2,3,4,*
1
International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
2
International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
3
Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan
4
Graduate School of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan
*
Author to whom correspondence should be addressed.
Appl. Sci. 2017, 7(11), 1203; https://doi.org/10.3390/app7111203
Received: 6 October 2017 / Accepted: 14 November 2017 / Published: 22 November 2017
(This article belongs to the Special Issue Shape Memory Polymers)
Shape-memory polymers have seen tremendous research efforts driven by the need for better drug carries and biomedical devices. In contrast to these advancements, fabrication of shape-memory particles which actuate at body temperature remains scarce. We developed a shape-memory microparticle system with dynamically tunable shapes under physiological temperature. Temperature-responsive poly(ε-caprolactone) (PCL) microparticles were successfully prepared by an in situ oil-in-water (o/w) emulsion polymerization technique using linear telechelic and tetra-branched PCL macromonomers. By optimizing the mixing ratios of branched PCL macromonomers, the crystal-amorphous transition temperature was adjusted to the biological relevant temperature. The particles with a disk-like temporal shape were achieved by compression. The shape recovery from the disk to spherical shape was also realized at 37 °C. We also incorporated magnetic nanoparticles within the PCL microparticles, which can be remote-controllable by a magnet, in such a way that they can be actuated and manipulated in a controlled way. View Full-Text
Keywords: shape-memory particles; poly(ε-caprolactone); magnetic-responsive shape-memory particles; poly(ε-caprolactone); magnetic-responsive
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MDPI and ACS Style

Uto, K.; Ebara, M. Magnetic-Responsive Microparticles that Switch Shape at 37 °C. Appl. Sci. 2017, 7, 1203.

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