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Open AccessCommunication
Appl. Sci. 2017, 7(11), 1203;

Magnetic-Responsive Microparticles that Switch Shape at 37 °C

International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan
Graduate School of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan
Author to whom correspondence should be addressed.
Received: 6 October 2017 / Accepted: 14 November 2017 / Published: 22 November 2017
(This article belongs to the Special Issue Shape Memory Polymers)
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Shape-memory polymers have seen tremendous research efforts driven by the need for better drug carries and biomedical devices. In contrast to these advancements, fabrication of shape-memory particles which actuate at body temperature remains scarce. We developed a shape-memory microparticle system with dynamically tunable shapes under physiological temperature. Temperature-responsive poly(ε-caprolactone) (PCL) microparticles were successfully prepared by an in situ oil-in-water (o/w) emulsion polymerization technique using linear telechelic and tetra-branched PCL macromonomers. By optimizing the mixing ratios of branched PCL macromonomers, the crystal-amorphous transition temperature was adjusted to the biological relevant temperature. The particles with a disk-like temporal shape were achieved by compression. The shape recovery from the disk to spherical shape was also realized at 37 °C. We also incorporated magnetic nanoparticles within the PCL microparticles, which can be remote-controllable by a magnet, in such a way that they can be actuated and manipulated in a controlled way. View Full-Text
Keywords: shape-memory particles; poly(ε-caprolactone); magnetic-responsive shape-memory particles; poly(ε-caprolactone); magnetic-responsive

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Uto, K.; Ebara, M. Magnetic-Responsive Microparticles that Switch Shape at 37 °C. Appl. Sci. 2017, 7, 1203.

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