A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters
Abstract
Featured Application
Abstract
1. Introduction
2. Framework and Methodological Basis
3. Results and Discussion
3.1. Chemical Hazard Domain
3.2. Biological Hazard Domain
3.3. Radiological and Nuclear Hazard Domain
3.4. Role of Exposure Routes and Physical Properties
3.5. Integration into a Communicative System
4. Practical Applications
- 1, 2, 3+: reaction depending on how many victims are identified on scene; if three or more, CBRN accident is likely to have happened.
- 5S: Sights, Signs, Smells, Sounds, Symptoms; identification of phenomena accompanying the suspected incident.
- Remove x3: (Remove yourself, remove clothes, remove residues of agents (means depend on the situation) by washing them out.
- CBRN Evacuation: more complicated than in case of fire.
- Initial decontamination: based on symptoms, contamination routes, and available resources.
4.1. Examples
4.2. Application to the Historical CBRNE Situations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
5S | Sights, Signs, Smells, Sounds, Symptoms |
ADR | Accord relatif au transport international des marchandises Dangereuses par Route |
AEGL | Acute Response Guideline Level |
ARS | Acute Radiation Syndrome |
CBRN | Chemical, Biological, Radiological, and Nuclear |
CBRNE | Chemical, Biological, Radiological, Nuclear, and Energetic |
CDC | Centers for Disease Control and Prevention |
DOT | USDOT Department of Transportation (US) |
DSTL | Defense Science and Technology Laboratory |
ECHA | European Chemical Agency |
EPA | USEPA Environmental Protection Agency |
CWAs | Chemical Warfare Agents |
GHS | Globally Harmonized System (of Classification and Labelling of Chemicals) |
G-I | Gastrointestinal (route of exposure) |
HAZMAT | Hazardous materials |
HSDB | Hazardous Substances Data Bank |
IAEA | International Atomic Energy Agency |
ICRP | International Commission on Radiological Protection |
ID50 | Median Infectious Dose |
ISO | International Organization for Standardization |
LD50 | Median Lethal Dose |
METHANE/ ETHANE | Major incident, Exact location, Type of incident, Hazards, Access, Number of casualties, required Emergency services |
NPSA | National Protective Security Authority |
PHE | Public Health England |
PPE | Personal Protective Equipment |
RAR | Recognize, Assess, React |
RDD | Radiological Dispersal Device |
STOT | Selective Target Organ Toxicity |
TICs | Toxic Industrial Chemicals |
WHO | World Health Organization |
WMD | Weapons of Mass Destruction |
WR | Radiation weighting factor |
WT | Tissue sensitivity factor |
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Exposure Circumstances | Known or Approximated 1 | Unknown or Poorly Approximated | Scientific and Technical Objectives |
---|---|---|---|
Occupational exposure/ | Hazard identity Exposure route Concentration, Time, location, Exposed subjects | Provide safe workplace conditions and operational safety | |
Accidental exposure of professionals/ | Hazard identity Exposure route Concentrations, amount Location Exposed subjects | Date, time, atmospheric conditions | Reduce the risk of operations |
Accidental exposure of the general public/ Hazardous material | Hazard identity Exposure route Concentration, Amount, Location, Exposed population 1 | Date, time, atmospheric conditions | Reduce risk, facilitate response, reduce the number of casualties |
Malevolent CBRN incident/ Agent-by-diversion | Exposed population 1 Place | Date, time Hazard identity, Exposure route Concentration, amount Atmospheric conditions | Build awareness Reduce risk Prevent and prepare Facilitate response Reduce number of casualties |
Exposure due to wartime WMD attack/ Agent-by design | Type of agent | Time, delivery, atmospheric conditions, amount | Reduce casualties Continue operations, Protect forces |
Interaction | Impact Type | Protection |
---|---|---|
Systemic reaction | Neural, e.g., nerve agents Mitochondrial, e.g., cyanides Chemical: alteration of tissue properties, e.g., Cl2, Phosgene reaction in alveoli DNA modification, e.g., Mustard Gas Immune response, e.g., sensitizers | No natural protection |
Non-specific surface reaction | Oxidizing | No natural protection |
Acid/base: H+, OH− | Skin offers some physical protection |
Exposure Factors | ||||
---|---|---|---|---|
Exposure | The Organism’s Barrier Strength | Contact Surface | Physiological or Physical Exposure: Examples of Simplified Instant Controls | Density of the Agent |
Inhalation | Weak, easily crossed | Large | Non-controllable: in extreme situations, stop breathing, e.g., until leaving contained space or when crossing a suspicious cloud | Low |
Skin | Strong barrier except for some chemical agents | Moderate | Controllable: cover skin if dermal symptoms are observed, remove any settled liquid | High |
G-I tract from cross-contamination | Weak barrier, easily crossed | Large | Controllable: don’t touch lips directly or indirectly (through eating, drinking, smoking, vaping) | High |
G-I tract from food chain | Weak barrier Easily crossed | Large | Controllable if expected: stop eating if poisoning symptoms observed; if food only food swallowed, consider inducing vomiting | High |
Parenteral (CBRNe—or RDD induced) | Weak barrier/no barrier | Undefined, small to moderate | Not controllable: only professional medical assistance | High |
Exposure | Precautions Situational | Precautions Response 1 | Hazard Endpoint & Limit |
---|---|---|---|
Inhalation | Slow breathing rate No rapid movements Mark or provisionally adsorb the spillage If systemic or respiratory symptoms—assign priority triage Report to the crisis center | Remove from contaminated zone | Hazard: Acute toxicity Endpoint: Death 2 |
Hazard: Acute toxicity Endpoint: Respiratory sensitization 5 | |||
Hazard: Skin allergic reaction Endpoint: Skin sensitization 5 | |||
Oral | Block access to food No mouth touching, no eating, no smoking If systemic symptoms: assign to priority triage | Rinse mouth if exposed to corrosive matter Do not induce vomiting (except in case of food poisoning, consult a physician) | Hazard: Acute toxicity Endpoint: death 3 |
Hazard: Skin allergic reaction Endpoint: skin sensitization 5 | |||
Dermal | Wash affected skin with any nontoxic, noncorrosive fluid Watch for symptoms 4 to approximate actual exposure If systemic symptoms—assign to priority triage Report to the crisis center | Take off contaminated clothing Rinse affected skin with water | Hazard: Acute toxicity Endpoint: Death 4 |
Hazard: Acute toxicity Endpoint: Skin sensitization 5 | |||
Hazard: Skin corrosion Endpoint Skin necrosis 5 | |||
Ocular | No eye touching Assign to priority triage | Remove from contaminated zone, Rinse with water | Endpoint: Eye damage 5 |
Parenteral | Assign to Priority triage | Not standardized | Not standardized |
Chemically Reacting with Living Organisms (Toxic) CBRN Agents in GHS Systematics | |||
---|---|---|---|
Physical Form | Exposure Route 1 | Hazard Statement for the Highest Category | Dose Value 1 or Description for the Endpoint Extreme Category |
Solids (toxins) | Ingestion | Fatal if swallowed | <5 mg/kg |
Solid aerosol | Ingestion Endpoint: death | Fatal if inhaled | <0.05 mg/L |
Inhalation, Endpoint: resp. hypersensitivity | May cause allergy, asthma symptoms, or breathing difficulties if inhaled | Asthma, rhinitis/conjunctivitis, and alveolitis | |
Dermal Endpoint: skin damage Ocular Endpoint: eye damage | Severe skin burns Eye damage | Destruction of tissue/visible necrosis Irreversible effect on iris/cornea/conjunctiva | |
Parenteral 2 | n/a | Damage analogous to dermal or Internal contamination of the bloodstream or the lymphatics | |
Liquid aerosol | Inhalation, Endpoint: death | Fatal if inhaled | <0.05 mg/L |
Inhalation Endpoint: irreversible or other serious, long-lasting adverse health effects | AEGL-2 | As a substance-specific time/concentration matrix | |
Inhalation Endpoint: notable discomfort, irritation, or certain asymptomatic non-sensory effect | AEGL-1 | As a substance-specific time/concentration matrix | |
Endpoint: Resp. hypersensitivity | May cause allergy, asthma symptoms, or breathing difficulties if inhaled | Asthma, rhinitis/conjunctivitis and alveolitis | |
Ingestion, Endpoint: death | Fatal if swallowed | <5 mg/kg | |
Dermal, Endpoint: death | Fatal when in contact with skin | <50 mg/kg b.w. | |
Dermal Endpoint: skin damage Ocular Endpoint: eye damage | Severe skin burns Eye damage | Destruction of tissue/visible necrosis Irreversible effect on iris/cornea/conjunctiva | |
Parenteral | n/a | Damage analogous to dermal or Internal contamination of the bloodstream or the lymphatics | |
Liquid | Dermal, Endpoint: death | Fatal when in contact with skin | Dermal: <50 mg/kg b.w. |
Ingestion, Endpoint death | Fatal if swallowed | Oral: <5 mg/kg | |
Dermal, Endpoint: skin damage Ocular, Endpoint: eye damage | Severe skin burns Eye damage | Destruction of tissue/visible necrosis Irreversible effect on iris/cornea/conjunctiva | |
Parenteral | n/a | Damage analogous to dermal or Internal contamination of the bloodstream or the lymphatics | |
Vapor | Inhalation, Endpoint: death | Fatal if inhaled | <0.5 mg/L |
Inhalation Endpoint: respiratory hypersensitivity | May cause allergy or asthma symptoms or breathing difficulties if inhaled | Asthma, rhinitis/conjunctivitis and alveolitis | |
Inhalation Endpoint: irreversible or other serious, long-lasting adverse health effects | AEGL-1 | As substance-specific time/concentration matrix | |
Inhalation Endpoint notable discomfort, irritation, or certain asymptomatic non-sensory effect | AEGL-1 | As substance-specific time/concentration matrix | |
Dermal, Endpoint: death | Fatal when in contact with skin | <5 mg/kg b.w. | |
Dermal, Endpoint damage Ocular Endpoint damage | Severe skin burns Eye damage | Destruction of tissue/visible necrosis Irreversible effect on iris/cornea/conjunctiva | |
Gas | Inhalation, Endpoint death | Fatal if inhaled | <100 ppmV |
Inhalation Endpoint hypersensitivity | May cause allergy or asthma symptoms, or breathing difficulties if inhaled | Asthma, rhinitis/conjunctivitis and alveolitis | |
Inhalation Endpoint: irreversible or other serious, long-lasting adverse health effects | AEGL-2 | As substance-specific time/concentration matrix | |
Inhalation Endpoint notable discomfort, irritation, or certain asymptomatic non-sensory effect | AEGL-1 | As substance-specific time/concentration matrix | |
Dermal, Endpoint: death | Fatal when in contact with skin | <5 mg/kg b.w. | |
Biological infectious materials | |||
Exposure route Source | Reservoir | Examples | Endpoint/symptoms |
Ingestion | Food and water | Bacteria: Bacillus anthracis, Bacillus cereus, Vibrio cholerae, Clostridium botulinum. Viruses: Rotavirus, Astrovirus, Adenovirus, Norovirus. Parasite: Entamoeba histolytica, Trichinella spiralis, Taenia spp. | General symptoms (fever, weakness) specific G-I tract symptoms |
Inhalation | Airborne aerosol human or mechanically dispersed | Bacteria: Bacillus anthracis, Legionella pneumophila, Mycobacterium species, Brucella spp. Viruses: Othopoxviruses, Hantaviruses, Influenza viruses, Sin Nombre virus, SARS-CoV-2, Fungus: Aspergillus spp., Histoplasma capsulatum, Coccidioides immitis, Cryptococcus neoformans | General symptoms |
Parenteral (bite) | Vector-borne | Bacteria: Francisella tularensis, Borrelia burgdorferi. Viruses: West Nile, Chikungunya. Parasite: Plasmodium falciparum, Babesia microti | General and disease-specific symptoms |
Parenteral (wound) | CBRNe incident delivered | Bacteria: Clostridium botulinum, Staphylococcus aureus. Viruses: Hepatitis C virus (HCV), Orf virus. Fungus: Cladosporium cladosporioides, Aspergillus niger | Bloodstream or the lymphatic system infection |
Direct | Skin-to- skin | Bacteria: Bacillus anthracis, Staphylococcus aureus. Viruses: Human papillomavirus (HPV), Herpes simplex virus—HSV. Fungus: Ringworm (Tinea infections), Trichophyton (Onychomycosis) | Local skin lesions |
bodily fluids, e.g., vomit | Bacteria: Yersinia pestis, Francisella tularensis. Viruses: Ebola, Marburg virus. Fungus: Candida albicans, Candida auris | Fever, multiple organs failure | |
dirty hands-to- mucous membranes | Bacteria: Shigella spp., E. coli O157:H7, Viruses: SARS-CoV-2, Rotavirus. Fungus: Candida albicans, Trichophyton rubrum | Conjunctivitis | |
Materials emitting ionizing radiation | |||
Exposure route endpoint | Point source (debris) Closed source (industrial, medical) | Gamma | Dose dependent on Source strength, time, distance, and attenuating barriers |
Inhalation Endpoint: Death | Aerosol | Alpha, beta, gamma | Internal body contamination, effect depends on the source strength and decay |
Inhalation Endpoint: Cancer or organ damage | Aerosol | Cancer or organ damage | |
Dermal | Aerosol | Alpha, beta, gamma | Dose dependent on source strength |
Parenteral | Solid particles | Alpha, beta, gamma | Internal body contamination, the effect depends on the source strength and decay |
Physically damaging CBRNE | |||
Physical form | Type of reaction | Energy delivery form | Health effects |
Gas, liquid, solid | Highly reactive with water | Flame, heat | Skin burns internal burns |
Gas, vapor, solid | Self-reacting | Explosion, projection, fire | Mechanical fragmentation burns |
Solid, liquid | Self-reaction, Reaction upon ignition or exposure to air | Explosion; fire | Mechanical fragmentation burns |
Hazard | Effects Description | GHS Hazard Codes 1 | Pictograms | |
---|---|---|---|---|
GHS-based | ||||
Health hazards | ||||
Hazard | Description | Hazard statement | Pictogram | |
Effect | Action | |||
Acute toxicity | Fatal | POISO-NING | H300, H310, H330 | Skull and bones |
Toxic | H301, H311, H331 | Skull and bones | ||
Harmful | H302, H312, H332 | Exclamation mark | ||
Corrosion 2 skin/eye damage Irritation skin/eye | Severe Burns Irritation | TISSUE DAMAGE CHEMICAL BURNS | H314, H318 H315, H319 | Dripping acid Exclamation mark |
Respiratory/skin sensitization | May cause allergy, asthma, breathing difficulties | SENSITI-ZING | H334 | Health hazard |
H317 | Exclamation mark | |||
Selective target Organ Toxicity—Single exposure | Causes damage to (organ) 3 | TOXIC TO TARGET ORGAN | H370 | Health hazard |
May cause… damage to organ… | H371 H335 | Exclamation mark | ||
Physical hazards | ||||
Explosive | Unstable | PHYSICAL DAMAGE | H200 to H204 | Exploding bomb |
Mass explosion | ||||
Severe projection | ||||
Fire, blast or explosion | ||||
Flammable | Extremely flammable gas | HEAT BURNS | H220 | Flame over the surface |
Pyrophoric | H250 | |||
Emitting flammable gases in contact with water | H251 | |||
Self-heating | H252 | |||
Other reactive Self-reactive | Heating may cause explosion/fire May cause fire/explosion May intensify fire | PHYSICAL DAMAGE | H240–H242 | Exploding bomb or flame over a surface |
Pyrophoric Peroxides Oxidizers | CHEMICAL BURNS | H271, H272 | Flame over circle | |
Non-GHS based | ||||
Weaponized CWA | Nerve agents Blister agents Choking agents Blood-poisoning agents Psychoactive agents Incapacitating agents | Corresponding to GHS H330, H310 H300 Also H350, H370 | Three-pronged black or red shape in a trefoil on yellow | |
Biological hazards | ||||
All | No standardized effect descriptions | No symbolic hazard levels | Black triple crescent in a trefoil on yellow | |
Radiological/Nuclear hazard | ||||
Ionizing radiation | General | Text: Warning; Radioactive material or ionizing radiation + Black trefoil in a yellow circle (ISO 361 standardized) | ||
High-level sealed-source ionizing radiation | Black trefoil with rays emitting on a skull and a running figure | |||
Any transported radiation-emitting material | Diamond with a text: “Radioactive” | |||
Transported fissile material | “diamond with a text “Fissile” |
Properties and Features Satisfying the CBRN Information Needs | ||
---|---|---|
Subdomain | Existing classifications | Looked for in CBRN |
Chemical | Endpoint: death, damage, asthma/allergy, selective target organ toxicity | Endpoint: death, damage, asthma/allergy, selective target organ toxicity |
Physical, chemical properties | Physical, chemical, and senses-determined (olfactory, visible) | |
Route of exposure: inhalation, skin/ocular, ingestion | Inhalation, skin/ocular, ingestion, parenteral | |
Symptoms | Manifestations, severity, onset | |
Biological | Endpoint: individual: death, hospitalization, population: epidemic, pandemic | Endpoint: death, hospitalization |
Virulence: LD50 median lethal dose, ID50 median infectious dose, R0 threshold for herd immunity | Route of exposure: inhalation, ingestion, direct | |
Pathogenicity Transmissibility | ||
Treatment/remedies | Behavioral remedies | |
Alert | Rapid, days, weeks | |
Radiological/Nuc-lear | Endpoint: Death, cancer, or organ damage | Endpoint: Death, cancer, or organ damage |
Energy: equivalent dose, effective dose | Energy: equivalent dose, effective dose | |
Target organ Decay: in relation to absorbed corpuscular radioactive matter | Attenuation: attenuation factors | |
Exposure routes: direct irradiation, inhalation, ingestion, parenteral |
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Gorniak, L.; Cichon, N.; Stela, M.; Niemcewicz, M.; Podogrocki, M.; Siadkowski, A.; Ceremuga, M.; Bijak, M. A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters. Appl. Sci. 2025, 15, 10421. https://doi.org/10.3390/app151910421
Gorniak L, Cichon N, Stela M, Niemcewicz M, Podogrocki M, Siadkowski A, Ceremuga M, Bijak M. A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters. Applied Sciences. 2025; 15(19):10421. https://doi.org/10.3390/app151910421
Chicago/Turabian StyleGorniak, Leslaw, Natalia Cichon, Maksymilian Stela, Marcin Niemcewicz, Marcin Podogrocki, Adrian Siadkowski, Michal Ceremuga, and Michal Bijak. 2025. "A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters" Applied Sciences 15, no. 19: 10421. https://doi.org/10.3390/app151910421
APA StyleGorniak, L., Cichon, N., Stela, M., Niemcewicz, M., Podogrocki, M., Siadkowski, A., Ceremuga, M., & Bijak, M. (2025). A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters. Applied Sciences, 15(19), 10421. https://doi.org/10.3390/app151910421