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Article

A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters

1
Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland
2
Department of Security and Crisis Management, Faculty of Applied Sciences, WSB University, Zygmunta Cieplaka 1c, 41-300 Dabrowa Gornicza, Poland
3
Military Institute of Armoured and Automotive Technology, Okuniewska 1, 05-070 Sulejówek, Poland
*
Author to whom correspondence should be addressed.
Appl. Sci. 2025, 15(19), 10421; https://doi.org/10.3390/app151910421
Submission received: 12 August 2025 / Revised: 21 September 2025 / Accepted: 23 September 2025 / Published: 25 September 2025

Abstract

Featured Application

The proposed CBRN hazard classification framework aims to integrate all CBRN silos’ hazard information, simplify it, and make it understandable for civil society and, particularly, for the potentially engaged groups. Sharing scientific background with the classifications used by emergency services and occupational safety, it can be directly applied by emergency responders, security services, and public safety agencies to rapidly assess and communicate risks during chemical, biological, radiological, nuclear, and energetic incidents. Integrating toxicological endpoints, exposure routes, and observable situational indicators into a unified, field-adapted system enables effective decision-making even when the hazardous agent is unidentified. This approach is especially valuable in the first minutes of an incident, supporting triage, protective action, and public warning, while also serving as a training and planning tool to enhance local and national CBRN preparedness.

Abstract

CBRN incidents are characterized by high uncertainty in terms of agent identity, dissemination methods, and situational context. This unpredictability complicates effective and timely response, especially in the initial phase before specialist services arrive, and lays the burden of applying protection and response measures on members of civil society participating in the incident. This paper proposes a structured classification framework for CBRN hazards to address this gap, integrating key characteristics from existing systems such as the GHS (Globally Harmonized System), WHO (World Health Organization) biosafety levels, and radiological exposure guidelines. The system emphasizes properties relevant for first responders and non-specialists, including observable effects, exposure routes, and hazard endpoints such as toxicity, virulence, and radiation dose. The goal is to enable rapid hazard recognition, improve communication, and support situational decision-making in public security scenarios.

1. Introduction

Chemical, biological, radiological, and nuclear threats represent a complex challenge for public safety and emergency response systems due to their inherent unpredictability regarding agent type, dissemination method, location, and impact. Unlike controlled exposures in occupational or industrial settings, CBRN events are often characterized by unknown variables, including the nature and quantity of the hazardous material, exposure routes, environmental conditions, and affected populations [1,2]. The increasing risk of intentional release of hazardous agents, such as in terrorism, sabotage, or hybrid warfare, further complicates preparedness efforts. In such scenarios, the ability to rapidly recognize, classify, and communicate the type and severity of the threat becomes critical, especially in the early stages of an incident when first responders and local site personnel must act before the arrival of specialized CBRN services [3].
Civil society is, albeit often neglected, a potential partner in building CBRN resilience [4]. This capacity has been noticed by the European Commission, which is currently initiating many DRS (Disaster Resilient Society) projects focused on CBRN threats. Those leading resilience-enhancing projects implemented within the ISF have noted that first responders from the police and fire departments, except for a limited number of specialized units, lack a deep understanding of CBRN threats and only have a general understanding of the consequences. Therefore, the results of several CBRN trainings within the DRS-related European Commission Internal Security Fund Police projects [5,6,7,8] dedicated to raising CBRN resilience among civil society, particularly among facility or infrastructure operators identified as potentially exposed, allow us to conclude that the general population, facility operators, and non-specialized state and local services will benefit from introducing a system that more deeply explains the nature of threats, systematizes knowledge, and improves threat communication. The gained experience indicates that these groups, mainly consisting of personnel in charge of entities or infrastructure that gather the general public, need to understand the hazards at a level superior to that of the general public but not as advanced as emergency response professionals. In building prevention, and from the time of an incident to the arrival of responders, actions undertaken by that group are vital for reducing the consequences. Knowledge-building and training methodology of such a group differ from those adopted for professionals, i.e., civil protection or military, as they are time-consuming, requiring additional capacities, and assuming accessibility of resources that are not routinely allocated. Helping that group to understand the threat by creating a classification of hazards, implying practical consequences, and being understandable for civil protection, is a vital resilience-building component of civil protection. In summary, this system serves to include in the prevention and response a community that has above-average levels of vulnerability, is capable of being a partner in emergency response, and has limited resources and technical means.
Existing classification systems—such as the GHS, WHO biosafety guidelines, and radiological hazard assessment tools developed by the ICRP (International Commission on Radiological Protection)—were primarily designed for risk management under controlled conditions [9,10]. The classifications from different CBRN compartments are rarely listed together or compared, which causes concentration on one hazard silo at the expense of the others. While well-established within their respective domains, these systems often lack situational flexibility and are not tailored to the operational realities of CBRN incidents. They also do not provide simplified tools for decision-making by non-specialists in high-pressure environments. Additionally, the legacy of military chemical warfare agent classification continues to dominate the discourse, despite the growing significance of hazards arising from diverted peaceful-use materials. These include industrial toxins, medical radiological sources, or bioactive compounds used in agriculture and sanitation, which can all be adapted for malicious purposes [11].
In response to these limitations, this work proposes a practical approach to CBRN hazard classification that adapts existing systems to the operational needs of emergency response. The proposed classification emphasizes observable effects, critical exposure routes, and health endpoints relevant to situational assessment. It also introduces an expanded conceptual model—CBRNE (Chemical, Biological, Radiological, Nuclear, and Energetic)—that accounts for energetic hazards such as explosions and fires, which frequently accompany malicious CBRN events. This model seeks to support both preventive planning and real-time management of incidents, providing a simplified yet scientifically grounded framework that can enhance local CBRN resilience and communication capabilities.

2. Framework and Methodological Basis

CBRN hazard events differ significantly from standard industrial, occupational, or environmental exposure scenarios due to the multitude of unknowns and the high variability in their manifestation. The unpredictability of time, location, type, quantity, and method of hazardous agent release makes classical hazard communication systems insufficient in the context of public security incidents involving chemical, biological, radiological, or nuclear agents. While traditional systems rely on predefined scenarios, controlled environments, and deterministic planning, the nature of CBRN events demands a more flexible, rapidly deployable classification approach that supports situational awareness and decision-making under uncertainty.
A central methodological assumption of this classification framework is that in a typical CBRN event, the identity of the hazardous agent, its concentration, delivery method, and even the route of exposure may be initially unknown. Consequently, the system must allow for inference and estimation based on observable features, rather than rely solely on confirming agent-specific data. This stands in contrast to domains such as occupational safety or industrial risk assessment, where exposure parameters are well-defined, and classification is used primarily for planning and regulatory compliance.
Table 1 of this study presents a comparative overview of different exposure contexts—ranging from workplace incidents to terrorist attacks—highlighting the increasing degree of uncertainty that characterizes CBRN events. In such settings, where both the agent and its behavior are undefined, precise dose–response calculations become impractical or even misleading. Instead, the emphasis shifts toward qualitative descriptors that support recognition of patterns, symptoms, and situational indicators.
Another foundational element of the proposed classification is the inclusion of both “agents-by-design” (i.e., substances or organisms engineered for deliberate harm, such as nerve agents or weaponized pathogens) and “agents-by-diversion” (i.e., materials originally produced for peaceful use that can be repurposed for malicious acts). The latter category is often overlooked in conventional military or regulatory classification systems, despite representing a significant portion of real-world CBRN threats. Examples include industrial biocides, radiological medical sources, and agricultural toxins, all of which can be adapted for intentional dissemination.
The classification also distinguishes between the preventive and reactive (situational) functions of hazard assessment. In preventive contexts, scenarios may be constructed using assumed agent characteristics to model vulnerability and preparedness; however, in situational contexts—i.e., the first minutes or hours after an incident—hazard classification must enable immediate estimation of risk and guide early protective actions, often before any laboratory confirmation is available. Therefore, the framework presented here focuses on supporting this initial window of decision-making, where the participation of non-professional actors and the lack of precise data must be compensated for by, among others, robust, simplified, situation-inferred communicative tools.
In response to this need, the structure of the classification model integrates components from regulatory systems such as the GHS, WHO biosafety levels, and ICRP radiological classifications, while also introducing dynamic elements not typically featured in those systems. These include intermediate health effect descriptors (e.g., “more than mild,” “irreversible but non-fatal”), environmental persistence, visibility of effects, and the symbolic severity of the incident—features particularly relevant in intentional acts meant to cause panic or disruption.
Ultimately, the classification framework is designed to serve three complementary purposes: (1) facilitate the rapid characterization of unknown agents based on observable indicators, (2) guide emergency decision-making in the absence of analytical confirmation (that comes at a later stage with the onset of response and forensic activities), and (3) support the training and operational readiness of actors involved in CBRN preparedness and response, particularly those outside of specialized scientific institutions.

3. Results and Discussion

3.1. Chemical Hazard Domain

Classifying chemical hazards in the CBRN context requires substantial modification of existing regulatory and military systems to meet the specificity of intentional, high-impact scenarios affecting civilian populations. Traditional classification systems—such as those in the GHS—are detailed and legally binding but are primarily designed for stable exposure scenarios in occupational or industrial environments [12,13]. Similarly, military taxonomies categorize CWA (chemical warfare agents) by strategic function (e.g., nerve, blister, choking agents), but remain disconnected from the requirements of civilian emergency response [11,14,15].
In contrast, based on the scientific data used to create occupational safety or military classification, the proposed framework focuses on practical criteria relevant during incident response: health endpoints, exposure routes, and physical-chemical properties that can be observed or inferred without immediate laboratory confirmation, and which are borrowed from the GHS system.
Table 2 summarizes the toxicodynamic mechanisms by which chemical agents affect biological systems. These include systemic actions (e.g., acetylcholinesterase inhibition by organophosphates), corrosive tissue damage, oxidative stress, DNA disruption, and immunological effects [16,17]. Each mechanism is mapped to GHS hazard codes, such as H300–H330 for acute toxicity, H314–H319 for skin and eye corrosion, and H370–H371 for organ-specific toxicity [12].
Occupational safety systems rely on accurate dose–response values to guide classification [18]. The practical use of those values is oriented toward the engineering of the workplace to reduce exposure or, in general, to provide workplace safety. At the same time, CBRN security has to deal with undefined, unstable, and dependent on environmental conditions, which can change by order of magnitude within seconds. This attempt has to assume exposure to a hazard beyond acceptable safety limits, similar to the AEGL (Acute Exposure Guideline Levels) concept, using linguistic descriptors that are fuzzy and intuitive instead of numerical limits. This framework therefore uses route-specific proxies for estimating dose severity.
Table 3 introduces a semi-qualitative matrix approximating absorbed dose levels based on barrier resistance, surface area, control over exposure, and agent concentration. Inhalation is prioritized due to the respiratory system’s large surface area and limited natural defenses, especially in open-air or aerosol-generating events. Dermal exposure is also important, particularly for agents that are both hydrophilic and lipophilic and can rapidly cross the skin barrier [19,20]. Agent behavior depends not only on chemical structure, but also on physical form [14,15]. The framework, therefore, includes a cross-mapping of form, route, and clinical outcome.
Precautionary measures may be adopted for each type of exposure. A list of such standardized measures was assembled and tabularized in the GHS system. However, mass exposure situations require a supplementary approach. A summary of the integrated approach, including situational and standardized response-oriented precautions, is presented in Table 4.
Table 5 presents further linking of a physical form, exposure route, hazard, and dose limits.
Table 5 links each physical form to typical toxicological endpoints, based on AEGL categories and GHS statements. For instance, inhalation of certain vapors or aerosols may cause fatal outcomes at concentrations below 0.05 mg/L. The classification also includes intermediate categories such as “irreversible but non-fatal” or “moderate discomfort” to enhance early-stage decision-making when analytical confirmation is pending [12,13].
Importantly, the system incorporates energy-releasing chemical hazards (e.g., explosives, flammable vapors) under the extended “E” in the CBRNE model. These agents are frequently involved in real-world CBRN events, where the combined effects of toxic release and physical trauma (from fire, blast, or shockwave) demand integrated classification.
Table 6 places these hazards within the physical hazard classes of the GHS system (H200–H204 for explosives, H220–H252 for flammables), accompanied by visual symbols and brief descriptors to ensure immediate recognition and appropriate response [12,13].
Additionally, the framework highlights the growing concern of diverted-use chemical threats, such as TIC (toxic industrial chemicals), biocides, and pharmaceuticals. While not formally categorized as CWAs, these agents can cause mass harm when released intentionally. Their properties (e.g., aerosol-forming capacity, environmental persistence, reactivity) are often underappreciated in conventional systems. Databases like European Chemical Agency ECHA CHEM and HSDB (Hazardous Substances Data Bank) provide relevant toxicological data but lack operational context, which this model addresses.
By combining toxicological profiles, physical characteristics, exposure dynamics, and visual communication, the proposed classification offers a structured, field-ready tool for hazard recognition, scenario analysis, and responder training (Figure 1). It connects data-rich systems with real-time operational needs—enabling effective action even in the absence of confirmed agent identification.

3.2. Biological Hazard Domain

Biological hazards in the CBRN context present a distinct classification challenge due to the variability of biological agents, their interaction with human hosts, and their potential for uncontrolled secondary transmission. Unlike chemical or radiological agents, which act through predictable physicochemical mechanisms, biological agents have dynamic life cycles, can replicate and mutate, and often persist in the environment or spread through person-to-person contact [1,2,23]. This complexity requires a classification framework that supports decision-making in conditions of uncertainty and evolving outbreak scenarios.
Current international classification systems address biological hazards primarily from laboratory or regulatory perspectives. The WHO Biosafety Manual groups agents into four risk levels, based on pathogenicity, availability of treatment or prophylaxis, and whether risk applies primarily to individuals or communities [24,25]. The U.S. Centers for Disease Control and Prevention (CDC) uses a Select Agents and Toxins List, which emphasizes potential for bioterrorism and public health disruption. The European Federation of Biotechnology similarly classifies biological agents based on severity, dissemination potential, and environmental persistence [26]. While informative, these systems are not optimized for emergency use, where agent identification may be delayed, and decisions must be based on symptoms or initial epidemiological data.
In the proposed classification model, biological agents are assessed using operationally relevant parameters that facilitate situational judgment. These include the nature and severity of health endpoints, such as mortality, hospitalization, chronic illness, or the development of asymptomatic carrier states. Pathogenicity is defined as the likelihood of disease following exposure, whereas virulence relates to the severity of disease, including median lethal dose (LD50), median infectious dose (ID50), and threshold for herd immunity (R0). Transmissibility encompasses both the route of transmission (inhalation, ingestion, contact) and its mechanism (e.g., airborne, droplet, fomite-mediated). Latency and time to onset are critical for estimating the detection window and the urgency of response (Figure 2).
The availability of treatment or prophylaxis further modifies the hazard level by defining the potential for effective intervention. A summary of these criteria is presented in Table 7.
In contrast to chemical hazards, biological threats often lack well-defined exposure thresholds. Infectious dose values (ID50) are highly variable and depend on multiple factors, including agent strain, host condition, and environmental context. Consequently, classification relies more heavily on observable clinical patterns and epidemiological indicators. Descriptive categorizations such as “high individual risk but low transmission potential” allow responders to act even in the absence of confirmed agent identification [27].
The classification system also allows for the inclusion of emerging and genetically engineered pathogens, which are not always present in official lists. These include synthetic biology constructs, recombinant organisms, and engineered toxins. In such cases, characteristics such as replication rate, immune evasion, resistance to treatment, and environmental survivability serve as proxies for hazard classification [28]. This approach ensures preparedness for novel or hybrid threats.
Exposure routes play a key role in biological hazard behavior. Due to their efficiency and involuntary nature, inhalation and ingestion are the most relevant routes in public-space scenarios. Parenteral exposure is less common but may occur in the context of device-based delivery [29]. A matrix of typical symptom presentations and routes of exposure for selected pathogen classes is shown in Table 5.
Communication of biological hazards poses unique challenges. Technical vocabulary, taxonomic ambiguity, and evolving case definitions can confuse responders and delay action. To address this, the proposed classification integrates simplified hazard communication tools, including internationally recognized symbols and operational descriptors. Table 6 presents visual and verbal cues adapted to field conditions—such as the biohazard trefoil, along with interpretive descriptors like “invisible agent”, “delayed onset” or “requires airborne PPE”. These tools facilitate rapid risk recognition across diverse user groups.
Overall, the proposed biological hazard classification aligns scientific parameters with emergency management requirements. It emphasizes early symptom recognition, agent behavior inference, and actionability—particularly in contexts where information is incomplete and time is limited.

3.3. Radiological and Nuclear Hazard Domain

Radiological and nuclear hazards in the civilian CBRN context present distinct classification challenges due to their invisibility, long-term consequences, and the persistent fear they generate. While public perception often conflates radiological incidents with nuclear warfare, the practical risk landscape includes a broader range of events—from medical isotope releases and orphan sources to intentional dispersion of radioactive materials in so-called “dirty bombs” [30,31,32,33].
Unlike chemical or biological agents, ionizing radiation does not rely on chemical reactivity or biological replication. Its effects are mediated through energy transfer to biological tissues, leading to DNA damage, oxidative stress, and organ dysfunction. These effects vary widely depending on radiation type (alpha, beta, gamma, neutron), dose, dose rate, and duration of exposure [33,34,35]. The classification of radiological hazards must therefore consider not only the intrinsic properties of the source, but also the exposure scenario and route.
International standards, such as those from the ICRP, the U.S. EPA (Environmental Protection Agency), and the IAEA (International Atomic Energy Agency), offer dose-based risk models that distinguish between deterministic and stochastic effects. However, these models assume known exposure parameters and may not be readily applicable during emergency response [36,37,38]. In contrast, the framework proposed in this study emphasizes early hazard recognition based on observable symptoms, situational indicators, and agent properties that can be inferred or approximated during a radiological event (Figure 3).
As shown in Table 5, symptom onset and clinical presentation vary by exposure type and dose. Acute Radiation Syndrome (ARS) typically emerges after whole-body exposure above 1 Gy, with prodromal symptoms such as nausea, vomiting, and fatigue. In subacute cases, localized effects such as erythema or hair loss may indicate partial or prolonged exposure [42,43,44]. Because radiological symptoms can overlap with other medical conditions, classification also considers timing, clustering, and environmental indicators (e.g., radiation detector alarms, unusual contamination patterns).
Unlike biological and many chemical agents, radioactive materials may remain hazardous for extended periods due to physical half-life and environmental persistence. This necessitates, in the case of isotopes and persistent chemicals [39,40], the inclusion of variables such as isotope stability, volatility, and propensity for re-aerosolization during decontamination or cleanup. The classification system accounts for this by tagging isotopes with operational descriptors (e.g., “volatile alpha emitter—high internal hazard” or “persistent ground contaminant—low immediate effect, high long-term risk”).
Another distinguishing factor is the availability and complexity of protective measures. While shielding, distance, and time are standard protective principles, implementation in urban or public spaces can be limited [36,45]. Moreover, effective decontamination, especially of internal exposures, is often unavailable or delayed. Therefore, the classification integrates not only hazard potential but also feasibility of mitigation and monitoring.
Although nuclear detonation scenarios are beyond the scope of most civilian planning, certain features—such as mixed radiological, thermal, and blast effects—are relevant in dual-threat or hybrid incidents [46]. The framework allows for inclusion of such composite hazards within its extended model, supporting comprehensive planning and triage.
Overall, radiological hazard classification in this framework prioritizes route, source type, and symptom progression, while retaining compatibility with international guidelines. It supports responder decision-making by aligning physical science with operational risk and by enabling early differentiation between high-impact and lower-priority events in real time.

3.4. Role of Exposure Routes and Physical Properties

The route of exposure is one of the most critical variables in determining both the clinical outcome of hazardous agent contact and the appropriate protective measures to be taken. In CBRN incidents, exposure routes are rarely uniform or predictable; agents may enter the body through inhalation, dermal absorption, ingestion, or less commonly, via ocular or parenteral pathways. Each route involves distinct physiological barriers, surface areas, and absorption kinetics, which collectively influence toxic effects’ severity, latency, and reversibility [1,32,47].
Inhalation is the most significant route in open-space and aerosol-generating events. The respiratory tract presents a large, vulnerable surface with minimal protective layers, allowing for rapid systemic absorption of gases, vapors, and fine particulates [48,49]. Moreover, inhalation exposure is difficult to avoid in public or urban settings, especially when the agent is odorless or colorless. Consequently, agents that are volatile or form stable aerosols pose a disproportionately high operational risk and are prioritized in this classification model [50].
Dermal exposure becomes highly relevant in the case of agents with dual solubility properties—i.e., those capable of penetrating both lipophilic and hydrophilic skin layers [51]. Many chemical agents, such as vesicants and nerve agents, can penetrate intact skin and accumulate systemically. Environmental persistence, ambient temperature, and occlusion (e.g., clothing or personal protective equipment) can further modify the absorption profile [52]. While ingestion is less likely to be the primary route in CBRN events, it may occur secondary to contamination of food, water, or hands [1,53], and is particularly relevant in post-incident environments with inadequate decontamination.
Table 3 provides a route-specific framework for approximating absorbed dose based on four key modifiers: the strength of the biological barrier (e.g., skin vs. alveoli), the surface area available for contact, the degree of exposure control (e.g., availability of PPE or confinement), and the agent’s concentration or form. This approach allows for semi-quantitative risk assessment even in the absence of exact dose measurements, supporting real-time triage and response.
The physical form of the agent—gas, vapor, liquid, solid, aerosol—further interacts with the exposure route to define the resulting hazard. Gaseous and vaporous agents are more likely to cause respiratory toxicity, while liquids may result in dermal or ocular injury depending on volatility and solubility. Aerosols are particularly hazardous due to their dual potential for inhalation and deposition on mucous membranes or open wounds. Solids, while generally less bioavailable, can be dangerous if fragmented or re-aerosolized under certain conditions, such as explosions or mechanical disruption [50,54,55,56].
Table 5 integrates agent form and exposure route to map expected toxicological outcomes. For instance, fine-particle aerosols may result in deep lung deposition and irreversible pulmonary damage, whereas contact with corrosive liquids may lead to localized skin necrosis with systemic sequelae depending on absorption rate and dose [57,58,59,60].
Another critical consideration is the onset time of symptoms, which often varies by exposure route. Inhalation exposure to high-potency nerve agents may result in symptoms within seconds, whereas ingestion of biological toxins may take hours to manifest [61,62,63]. This latency influences both recognition and intervention: fast-onset symptoms allow for rapid clinical suspicion, while delayed symptoms may result in widespread exposure before containment measures are enacted [63].
The classification also accounts for environmental and behavioral factors that modify exposure probability and outcome. For example, confined spaces amplify inhalation risk, while heat and moisture increase dermal absorption [64]. These situational variables are not constant across events but must be integrated into hazard interpretation when deciding on protective measures or public health recommendations.
The framework provides a more realistic and actionable understanding of hazard behavior by systematically incorporating exposure route dynamics and physical properties into the classification model. It moves beyond simple agent identity or toxicity values to support triage, planning, and responder protection in real-world, time-sensitive contexts.

3.5. Integration into a Communicative System

Effective communication of hazard information is fundamental to CBRN preparedness and response. In high-pressure incidents where analytical confirmation is unavailable or delayed, responders and decision-makers must rely on simplified, intuitive signals to identify threats, assess severity, and initiate protective measures [65]. The challenge lies in translating highly technical, domain-specific knowledge into accessible, rapidly interpretable forms—particularly for mixed-audience environments involving first responders, medical personnel, public officials, and affected populations.
Traditional hazard communication systems, such as the GHS or transport labeling schemes (e.g., ADR, DOT), provide standardized visual and textual warnings based on chemical identity and classification. However, these systems often assume that the identity of the substance is known and that users are trained in chemical hazard interpretation [65,66,67,68]. Such assumptions cannot be made in real-world CBRN events—especially those involving intentional release or novel agents. Communication tools must therefore bridge the gap between scientific rigor and operational usability.
The framework developed in this study introduces a multi-level communicative model, designed to integrate seamlessly with the proposed classification structure. This model includes symbolic icons, color-coded risk indicators, textual descriptors, and scenario-based modifiers that together enable hazard recognition even under conditions of uncertainty. Rather than focusing solely on agent names or UN numbers, the communicative layer conveys what responders need to know: how the agent behaves, what kind of harm it can cause, how fast symptoms may appear, and what protection is necessary.
Table 6 presents a visual and semantic hazard matrix, where classified agents—whether chemical, biological, radiological, or energetic—are annotated with pictograms, effect profiles, and recommended response cues. For example, an inhalation-priority chemical agent may be marked with a gas mask symbol, the label “rapid onset,” and a red bar indicating “high severity.” A persistent biological agent with unknown identity may receive the biohazard symbol, the tag “invisible vector,” and a yellow bar indicating “delayed effects, quarantine advised.” Energetic hazards are tagged with explosion or flame icons, as well as physical impact descriptors to alert responders to blast-related trauma risk in addition to toxicity.
These communicative cues are not intended to replace technical data but to supplement and translate it for fast decision-making. The model maintains internal consistency by linking each communicative unit back to the core classification criteria—such as health endpoints, exposure route relevance, and physical-chemical properties. This ensures that visual indicators are meaningful, not arbitrary, and that they support scenario modeling, tabletop training, and real-time coordination.
Furthermore, the system accounts for compound threats and evolving incidents. It allows for combination symbols, layered risk cues, and updateable status tags (e.g., “unconfirmed agent”, “PPE escalation”, “secondary contamination suspected”). In this way, the classification is not only a static reference but a dynamic communication tool.
The framework supports interdisciplinary interoperability and rapid threat recognition by integrating classification logic with symbolic and textual representation. It facilitates everyday situational awareness across organizational and technical boundaries, empowering even non-specialist actors to contribute meaningfully to emergency response. Ultimately, this communicative model bridges the final gap between technical analysis and actionable knowledge—a crucial element in any effective CBRN system.
The framework presented above will be significantly empowered if combined with detection capacity, strengthening the relation between observation and the surety of response. Detection, which is considered an important preventive measure, is also a powerful response tool. It must be remembered that it delivers only partial information covering either a limited number of agents or describes a selection of chemically, biologically, or radiologically similar agents, with the range of identification spectrum inverse to accuracy. That applies equally to CBRN chemical, biological, and radiological subdomains. Bringing together detection information with the observed form, exposure route, observed effects, classification typical for those effects, and possibly knowledge of some adverse effects, may help narrow the agent search and conclude undertaking measures, supporting the decision, e.g., whether to begin with evacuation or removal of the agent. Some examples are provided below.

4. Practical Applications

The proposed hazard identification and communication methodology can serve as a framework in decision-making during a potential CBRNE incident. The practical applications discussed in this paper, in addition to rapid hazard assessment and exposure reduction measures, include those taken by response services on the scene after their arrival. These actions aim to achieve exact hazard identification/confirmation, which is done by sampling and analysis, and further steps: triage, decision about decontamination, and extent of medical intervention. Sampling also supports investigation, an activity outside health concerns but essential, specifically in cases of deterministic CBRN releases. The role of sampling is envisaged in the charts presented in Figure 4, Figure 5 and Figure 6, following sampling and analysis results.
The full decision chart using components of the proposed classification framework is presented in Figure 4.
Based on the hazard identification and systematization described in this paper, the decision chart presented in Figure 4 allows better hazard understanding, improves identification and decision-making, contributes to communication, and unifies situation reports from the incident zone.
This algorithm for responding to the CBRN type of incident employs specific procedures listed below.
  • 1, 2, 3+: reaction depending on how many victims are identified on scene; if three or more, CBRN accident is likely to have happened.
  • 5S: Sights, Signs, Smells, Sounds, Symptoms; identification of phenomena accompanying the suspected incident.
  • Remove x3: (Remove yourself, remove clothes, remove residues of agents (means depend on the situation) by washing them out.
  • CBRN Evacuation: more complicated than in case of fire.
  • Initial decontamination: based on symptoms, contamination routes, and available resources.
These procedures have been developed and tested by globally recognized organizations such as DSTL (Defense Science and Technology Laboratory), CDC, NPSA (National Protective Security Authority), Protect UK, UK Health Security Agency, PHE (Public Health England), National Fire Chiefs Council, and others, mainly from the UK and the USA. At their origin, they all have one thing in common—they do not depend on or rely on the previously cited systems for categorizing CBRN or HAZMAT substances. At the same time, that knowledge would be helpful, particularly when supported by detection capacity, a functionality requiring understanding and systematization brought by the proposed framework. The latter is particularly relevant in the case of cross-border, regional, and any incidents at large public gatherings, being the subject of the CBRN security-related projects mentioned in the Introduction chapter. It appears that the services already use methods of determining risk based on sensory observation (smell, sight of clouds, oily spots on the surface of water, effects of poisoning on plants, absence or presence of typical insects, etc.), but do not relate them further to the scientifically based classifications and hazard communications systems.

4.1. Examples

The proposed framework and the procedures were tested in the exercises conducted as part of the previously mentioned projects. The application presented below comes from the NEST Project [8].
Scenario: In the middle of the congress day, the facility manager receives information from security staff who find yellow and white powders in a mobile air condition unit
The response is shown in Figure 5. It includes the existing detection device based on the tested antibody-based electrochemical biosensor used in the project. It is assumed that the antibody for the pathogen involved in the attack is among those available in the bio-detecting device.

4.2. Application to the Historical CBRNE Situations

Fortunately, CBRN mass incidents happen rarely. To demonstrate how the decision chart based on the proposed framework would work, an event from 1981 was selected [69,70]. On 27 October 1981, around noon, in the square in front of the main gate of the Sosnowiec Coal Mine, unidentified perpetrators threw three vials of gas from a passenger car. Two of them remained undamaged, while one began to emit an invisible but highly pungent gas. Within a few hours, over sixty people were hospitalized with symptoms of poisoning—mostly mine workers, as well as residents of nearby apartment buildings, including several children. The specialized chemical services arrived at the scene only late in the evening, several hours after the miners had secured the area themselves. The application of the chart would look as presented in Figure 6.
Short explanatory notice: The incident was provoked by secret services (SB) to support civil unrest related to the trial scheduled for the same day in the local District Court against Wojciech Figel and seven other “Solidarność” activists from the Sosnowiec Coal Mine.

5. Conclusions

The classification of CBRN hazards remains a critical but underdeveloped element of civilian emergency preparedness. While scientifically rigorous within their respective domains, existing systems are often unsuited to the operational demands of CBRN incidents—particularly those marked by uncertainty, intentionality, and time pressure. The framework proposed in this study addresses this gap by integrating toxicological, microbiological, radiological, and physical hazard characteristics into a unified, situationally adaptive classification model.
The model reinterprets these standards in light of emergency response needs by drawing upon internationally recognized systems such as GHS, WHO biosafety levels, ICRP radiological guidelines, and AEGL thresholds. It emphasizes key operational parameters, including health endpoints, exposure routes, onset latency, environmental persistence, and symbolic severity. Furthermore, it incorporates dual-use hazards and energetic threats, reflecting the increasingly hybrid nature of modern CBRN events.
A core innovation of the framework lies in its communicative structure, which enables effective information transfer across expert, responder, and public interfaces. By combining visual symbols, intuitive descriptors, and route-specific hazard profiling, the system supports rapid recognition, triage, and protective decision-making even in the absence of agent identification or analytical confirmation. This enhances its usability not only in acute response scenarios but also in training, planning, and cross-agency coordination.
The framework also recognizes the evolving threat landscape, including the proliferation of toxic industrial chemicals, biological toxins, and radioactive materials accessible outside military contexts. By including both “agents-by-design” and “agents-by-diversion,” the classification offers a more realistic and comprehensive perspective on civilian CBRN risks.
Overall, the proposed classification system serves as a bridge between scientific knowledge and field-level action. It offers a flexible yet structured approach to hazard identification and communication, designed to support pre-incident preparedness and in-incident response. Future research should explore its validation through simulation exercises, integration into digital decision-support tools, and potential role in harmonizing international CBRN communication standards.

Author Contributions

Conceptualization, L.G., M.S., M.N., A.S. and M.B.; Methodology, M.S.; Formal analysis, N.C.; Data curation, L.G.; Writing—original draft, L.G., N.C. and M.S.; Writing—review & editing, N.C., M.N., M.P., A.S., M.C. and M.B.; Visualization, N.C.; Supervision, M.B. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by the European Union’s Internal Security Fund—Police Grants Agreement No. 861643 and No. 101034226.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

The original contributions presented in this study are included in the article. Further inquiries can be directed to the corresponding author.

Conflicts of Interest

The authors declare no conflicts of interest.

Abbreviations

The following abbreviations are used in this manuscript:
5SSights, Signs, Smells, Sounds, Symptoms
ADRAccord relatif au transport international des marchandises Dangereuses par Route
AEGLAcute Response Guideline Level
ARSAcute Radiation Syndrome
CBRNChemical, Biological, Radiological, and Nuclear
CBRNEChemical, Biological, Radiological, Nuclear, and Energetic
CDCCenters for Disease Control and Prevention
DOTUSDOT Department of Transportation (US)
DSTL Defense Science and Technology Laboratory
ECHAEuropean Chemical Agency
EPAUSEPA Environmental Protection Agency
CWAsChemical Warfare Agents
GHS Globally Harmonized System (of Classification and Labelling of Chemicals)
G-IGastrointestinal (route of exposure)
HAZMATHazardous materials
HSDBHazardous Substances Data Bank
IAEAInternational Atomic Energy Agency
ICRPInternational Commission on Radiological Protection
ID50Median Infectious Dose
ISOInternational Organization for Standardization
LD50Median Lethal Dose
METHANE/
ETHANE
Major incident, Exact location, Type of incident, Hazards, Access, Number of casualties, required Emergency services
NPSA National Protective Security Authority
PHE Public Health England
PPEPersonal Protective Equipment
RAR Recognize, Assess, React
RDDRadiological Dispersal Device
STOTSelective Target Organ Toxicity
TICsToxic Industrial Chemicals
WHOWorld Health Organization
WMDWeapons of Mass Destruction
WRRadiation weighting factor
WTTissue sensitivity factor

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Figure 1. Description of the proposed CBRN-oriented chemical hazard classification system.
Figure 1. Description of the proposed CBRN-oriented chemical hazard classification system.
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Figure 2. Description of the proposed CBRN-oriented biological hazard classification system.
Figure 2. Description of the proposed CBRN-oriented biological hazard classification system.
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Figure 3. Description of the proposed CBRN-oriented radiological and nuclear hazard classification system. The route of exposure is central to hazard assessment. Inhalation and ingestion are particularly concerning in cases of fine radioactive aerosols or contaminated food [39] and water supplies. External exposure becomes significant when high-energy photons or neutrons are involved, such as in close-range exposure to unshielded sources. The framework distinguishes between internalized radiation (with prolonged biological impact) and transient external exposure and integrates this into its classification logic [40,41].
Figure 3. Description of the proposed CBRN-oriented radiological and nuclear hazard classification system. The route of exposure is central to hazard assessment. Inhalation and ingestion are particularly concerning in cases of fine radioactive aerosols or contaminated food [39] and water supplies. External exposure becomes significant when high-energy photons or neutrons are involved, such as in close-range exposure to unshielded sources. The framework distinguishes between internalized radiation (with prolonged biological impact) and transient external exposure and integrates this into its classification logic [40,41].
Applsci 15 10421 g003
Figure 4. The decision flowchart employing the proposed classification. Release signs: (1) Blast, hiss, cloud. Emergence signs: (2) condensate, light refraction, odor. First symptoms: (3) Eye redness, rash, breathing difficulties (children, allergies). Further symptoms: (4) Conjunctivitis, laryngitis, asthma, rash, blisters. Identify hazard: (5) exposure route and symptoms: cross-check with Hazard class. Follow precautions: (6) P-statements [CLP]. Assigned to the identified hazard classes. Identify: (7) Possible B and R exposure routes. Detect: (8) When available to support inference. Limit exposure: (9) based on observations and hazard characteristics. Sample: (10) to support epidemiological or sanitary steps.
Figure 4. The decision flowchart employing the proposed classification. Release signs: (1) Blast, hiss, cloud. Emergence signs: (2) condensate, light refraction, odor. First symptoms: (3) Eye redness, rash, breathing difficulties (children, allergies). Further symptoms: (4) Conjunctivitis, laryngitis, asthma, rash, blisters. Identify hazard: (5) exposure route and symptoms: cross-check with Hazard class. Follow precautions: (6) P-statements [CLP]. Assigned to the identified hazard classes. Identify: (7) Possible B and R exposure routes. Detect: (8) When available to support inference. Limit exposure: (9) based on observations and hazard characteristics. Sample: (10) to support epidemiological or sanitary steps.
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Figure 5. Decision chart for the exercised scenario. Release signs: (1) No. Emergence signs: (2) spotted powder. First symptoms: (3) None. Further symptoms: (4) Conjunctivitis, laryngitis, asthma, rash, blisters. Identify: (7) Possible B and R exposure routes: inhalation. Detect: (8) When available to support inference; detected Anthrax bacteria spores. Limit (9) apply any available provisional respiratory protection. Sample: (10) to confirm the agent and support epidemiological or sanitary steps. Triage: Exposed individuals who qualify for advanced treatment.
Figure 5. Decision chart for the exercised scenario. Release signs: (1) No. Emergence signs: (2) spotted powder. First symptoms: (3) None. Further symptoms: (4) Conjunctivitis, laryngitis, asthma, rash, blisters. Identify: (7) Possible B and R exposure routes: inhalation. Detect: (8) When available to support inference; detected Anthrax bacteria spores. Limit (9) apply any available provisional respiratory protection. Sample: (10) to confirm the agent and support epidemiological or sanitary steps. Triage: Exposed individuals who qualify for advanced treatment.
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Figure 6. Decision chart for large-scale CBRN incident. Release signs: (1) Observed perpetrator. Emergence signs: (2) Odor. First symptoms: (3) None. Further symptoms: (4) Headaches, weakness, burning in the eyes and throat, coughs, nausea. Identify hazard: (5) Exposure via inhalation only; symptoms: non-specific, Hazard low or delayed, eventually H312. Follow precautions: (6) P-statements: For H312 hazard class P304 + P340 + P312 [22]. Detect: (8) No detection. Limit exposure: (9) Removal from the area. Sample: (10) Samples taken but announced only later.
Figure 6. Decision chart for large-scale CBRN incident. Release signs: (1) Observed perpetrator. Emergence signs: (2) Odor. First symptoms: (3) None. Further symptoms: (4) Headaches, weakness, burning in the eyes and throat, coughs, nausea. Identify hazard: (5) Exposure via inhalation only; symptoms: non-specific, Hazard low or delayed, eventually H312. Follow precautions: (6) P-statements: For H312 hazard class P304 + P340 + P312 [22]. Detect: (8) No detection. Limit exposure: (9) Removal from the area. Sample: (10) Samples taken but announced only later.
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Table 1. Comparison of the role of hazard description in various release scenarios. 1 Description is made assuming that risk is based on the defined scenarios, so data such as numbers are assumed.
Table 1. Comparison of the role of hazard description in various release scenarios. 1 Description is made assuming that risk is based on the defined scenarios, so data such as numbers are assumed.
Exposure CircumstancesKnown or Approximated 1Unknown or Poorly ApproximatedScientific and Technical Objectives
Occupational exposure/Hazard identity
Exposure route
Concentration,
Time, location,
Exposed subjects
Provide safe workplace conditions and operational safety
Accidental exposure of professionals/Hazard identity
Exposure route
Concentrations, amount
Location
Exposed subjects
Date, time, atmospheric conditionsReduce the risk of operations
Accidental exposure of the general public/
Hazardous material
Hazard identity
Exposure route
Concentration,
Amount,
Location,
Exposed population 1
Date, time, atmospheric conditionsReduce risk, facilitate response, reduce the number of casualties
Malevolent CBRN incident/
Agent-by-diversion
Exposed population 1
Place
Date, time
Hazard identity, Exposure route
Concentration, amount
Atmospheric conditions
Build awareness
Reduce risk
Prevent and prepare
Facilitate response
Reduce number of casualties
Exposure due to wartime WMD attack/
Agent-by design
Type of agentTime, delivery, atmospheric conditions, amountReduce casualties
Continue operations, Protect forces
Table 2. Toxicodynamic mechanisms and health endpoints of chemical agents.
Table 2. Toxicodynamic mechanisms and health endpoints of chemical agents.
InteractionImpact TypeProtection
Systemic reactionNeural, e.g., nerve agents Mitochondrial, e.g., cyanides
Chemical: alteration of tissue properties, e.g., Cl2, Phosgene reaction in alveoli
DNA modification, e.g., Mustard Gas
Immune response, e.g., sensitizers
No natural protection
Non-specific surface reactionOxidizingNo natural protection
Acid/base: H+, OHSkin offers some physical protection
Table 3. Approximate dose impact by route of exposure and agent characteristics.
Table 3. Approximate dose impact by route of exposure and agent characteristics.
Exposure Factors
ExposureThe Organism’s Barrier StrengthContact SurfacePhysiological or Physical Exposure: Examples of Simplified Instant ControlsDensity of the Agent
InhalationWeak, easily crossedLargeNon-controllable: in extreme situations, stop breathing, e.g., until leaving contained space or when crossing a suspicious cloudLow
SkinStrong barrier except for some chemical agentsModerateControllable: cover skin if dermal symptoms are observed, remove any settled liquid High
G-I tract from cross-contaminationWeak barrier, easily crossedLargeControllable: don’t touch lips directly or indirectly (through eating, drinking, smoking, vaping) High
G-I tract from food chainWeak barrier
Easily crossed
LargeControllable if expected: stop eating if poisoning symptoms observed; if food only food swallowed, consider inducing vomiting High
Parenteral (CBRNe—or RDD induced)Weak barrier/no barrierUndefined, small to moderateNot controllable: only professional medical assistanceHigh
Table 4. List of precautionary and instantaneous measures in relation to a type of exposure. 1 Contamination-free zone established first. 2 For acute toxicity estimates (ATE) below 100 ppm (Class 1 or 2) or time-concentration calculated dose for toxicity Class 1 and 2. 3 For oral acute toxicity estimates (ATE) 50 mg/kg and below (Class 1 and 2). 4 Dermal exposure, contrary to inhalation and oral exposure, is specific to physical and chemical properties so that toxicity estimates cannot be applied to it [21]. 5 Descriptive, non-measurable.
Table 4. List of precautionary and instantaneous measures in relation to a type of exposure. 1 Contamination-free zone established first. 2 For acute toxicity estimates (ATE) below 100 ppm (Class 1 or 2) or time-concentration calculated dose for toxicity Class 1 and 2. 3 For oral acute toxicity estimates (ATE) 50 mg/kg and below (Class 1 and 2). 4 Dermal exposure, contrary to inhalation and oral exposure, is specific to physical and chemical properties so that toxicity estimates cannot be applied to it [21]. 5 Descriptive, non-measurable.
ExposurePrecautions
Situational
Precautions
Response 1
Hazard Endpoint &
Limit
InhalationSlow breathing rate
No rapid movements
Mark or provisionally adsorb the spillage
If systemic or respiratory symptoms—assign priority triage
Report to the crisis center
Remove from
contaminated zone
Hazard: Acute toxicity
Endpoint: Death 2

Hazard: Acute toxicity
Endpoint: Respiratory sensitization 5
Hazard: Skin allergic reaction
Endpoint: Skin sensitization 5
OralBlock access to food
No mouth touching, no eating, no smoking
If systemic symptoms: assign to priority triage
Rinse mouth if exposed to corrosive matter
Do not induce vomiting (except in case of food poisoning, consult a physician)
Hazard: Acute toxicity
Endpoint: death 3

Hazard: Skin allergic reaction
Endpoint: skin sensitization 5
DermalWash affected skin with any nontoxic, noncorrosive fluid
Watch for symptoms 4 to approximate actual exposure
If systemic symptoms—assign to priority triage
Report to the crisis center
Take off contaminated clothing
Rinse affected skin with water
Hazard: Acute toxicity
Endpoint: Death 4

Hazard: Acute toxicity
Endpoint: Skin sensitization 5

Hazard: Skin corrosion
Endpoint Skin necrosis 5
OcularNo eye touching
Assign to priority triage
Remove from contaminated zone,
Rinse with water
Endpoint: Eye damage 5
ParenteralAssign to Priority triageNot standardizedNot standardized
Table 5. Mapping of agent forms (gas, liquid, aerosol, solid) to health effects and exposure pathways. 1 Toxicity range values are taken from the CLP Regulation. 2 Information on the parenteral exposures was concluded from general knowledge as is omitted from the occupational exposure sources.
Table 5. Mapping of agent forms (gas, liquid, aerosol, solid) to health effects and exposure pathways. 1 Toxicity range values are taken from the CLP Regulation. 2 Information on the parenteral exposures was concluded from general knowledge as is omitted from the occupational exposure sources.
Chemically Reacting with Living Organisms (Toxic) CBRN Agents in GHS Systematics
Physical FormExposure Route 1Hazard Statement for the Highest CategoryDose Value 1 or Description for the Endpoint Extreme Category
Solids (toxins)IngestionFatal if swallowed<5 mg/kg
Solid aerosolIngestion
Endpoint: death
Fatal if inhaled<0.05 mg/L
Inhalation,
Endpoint: resp. hypersensitivity
May cause allergy, asthma symptoms, or breathing difficulties if inhaledAsthma, rhinitis/conjunctivitis, and alveolitis
Dermal
Endpoint: skin damage

Ocular
Endpoint: eye damage
Severe skin burns

Eye damage
Destruction of tissue/visible necrosis

Irreversible effect on iris/cornea/conjunctiva
Parenteral 2n/aDamage analogous to dermal or
Internal contamination of the bloodstream or the lymphatics
Liquid aerosolInhalation,
Endpoint: death
Fatal if inhaled<0.05 mg/L
Inhalation
Endpoint: irreversible or other serious, long-lasting adverse health effects
AEGL-2As a substance-specific time/concentration matrix
Inhalation
Endpoint:
notable discomfort, irritation, or certain asymptomatic non-sensory effect
AEGL-1As a substance-specific time/concentration matrix
Endpoint: Resp. hypersensitivityMay cause allergy, asthma symptoms, or breathing difficulties if inhaledAsthma, rhinitis/conjunctivitis and alveolitis
Ingestion,
Endpoint: death
Fatal if swallowed<5 mg/kg
Dermal,
Endpoint: death
Fatal when in contact with skin<50 mg/kg b.w.
Dermal
Endpoint: skin damage

Ocular
Endpoint: eye damage
Severe skin burns


Eye damage
Destruction of tissue/visible necrosis

Irreversible effect on iris/cornea/conjunctiva
Parenteraln/aDamage analogous to dermal or
Internal contamination of the bloodstream or the lymphatics
LiquidDermal,
Endpoint: death
Fatal when in contact with skinDermal: <50 mg/kg b.w.
Ingestion,
Endpoint death
Fatal if swallowedOral: <5 mg/kg
Dermal,
Endpoint: skin damage

Ocular,
Endpoint: eye damage
Severe skin burns


Eye damage
Destruction of tissue/visible necrosis
Irreversible effect on iris/cornea/conjunctiva
Parenteraln/aDamage analogous to dermal or
Internal contamination of the bloodstream or the lymphatics
VaporInhalation,
Endpoint: death
Fatal if inhaled<0.5 mg/L
Inhalation
Endpoint: respiratory hypersensitivity
May cause allergy or asthma symptoms or breathing difficulties if inhaledAsthma, rhinitis/conjunctivitis and alveolitis
Inhalation
Endpoint: irreversible or other serious, long-lasting adverse health effects
AEGL-1As substance-specific time/concentration matrix
Inhalation
Endpoint
notable discomfort, irritation, or certain asymptomatic non-sensory effect
AEGL-1As substance-specific time/concentration matrix
Dermal,
Endpoint: death
Fatal when in contact with skin<5 mg/kg b.w.
Dermal,
Endpoint damage
Ocular
Endpoint damage
Severe skin burns

Eye damage
Destruction of tissue/visible necrosis
Irreversible effect on iris/cornea/conjunctiva
GasInhalation,
Endpoint
death
Fatal if inhaled<100 ppmV
Inhalation
Endpoint
hypersensitivity
May cause allergy or asthma symptoms, or breathing difficulties if inhaledAsthma, rhinitis/conjunctivitis and alveolitis
Inhalation
Endpoint: irreversible or other serious, long-lasting adverse health effects
AEGL-2As substance-specific time/concentration matrix
Inhalation
Endpoint
notable discomfort, irritation, or certain asymptomatic non-sensory effect
AEGL-1As substance-specific time/concentration matrix
Dermal,
Endpoint: death
Fatal when in contact with skin<5 mg/kg b.w.
Biological infectious materials
Exposure route SourceReservoirExamplesEndpoint/symptoms
IngestionFood and waterBacteria: Bacillus anthracis, Bacillus cereus, Vibrio cholerae, Clostridium botulinum. Viruses: Rotavirus, Astrovirus, Adenovirus, Norovirus. Parasite: Entamoeba histolytica, Trichinella spiralis, Taenia spp.General symptoms (fever, weakness) specific G-I tract symptoms
InhalationAirborne aerosol human or mechanically dispersedBacteria: Bacillus anthracis, Legionella pneumophila, Mycobacterium species, Brucella spp. Viruses: Othopoxviruses, Hantaviruses, Influenza viruses, Sin Nombre virus, SARS-CoV-2, Fungus: Aspergillus spp., Histoplasma capsulatum, Coccidioides immitis, Cryptococcus neoformans General symptoms
Parenteral
(bite)
Vector-borneBacteria: Francisella tularensis, Borrelia burgdorferi. Viruses: West Nile, Chikungunya. Parasite: Plasmodium falciparum, Babesia microtiGeneral and disease-specific symptoms
Parenteral
(wound)
CBRNe incident deliveredBacteria: Clostridium botulinum, Staphylococcus aureus. Viruses: Hepatitis C virus (HCV), Orf virus.
Fungus: Cladosporium cladosporioides, Aspergillus niger
Bloodstream or the lymphatic system infection
DirectSkin-to- skinBacteria: Bacillus anthracis, Staphylococcus aureus. Viruses: Human papillomavirus (HPV), Herpes simplex virus—HSV. Fungus: Ringworm (Tinea infections), Trichophyton (Onychomycosis)Local skin lesions
bodily fluids, e.g., vomitBacteria: Yersinia pestis, Francisella tularensis. Viruses: Ebola, Marburg virus. Fungus: Candida albicans, Candida aurisFever, multiple organs failure
dirty hands-to- mucous membranesBacteria: Shigella spp., E. coli O157:H7, Viruses: SARS-CoV-2, Rotavirus. Fungus: Candida albicans, Trichophyton rubrumConjunctivitis
Materials emitting ionizing radiation
Exposure route endpointPoint source (debris)
Closed source (industrial, medical)
GammaDose dependent on
Source strength, time, distance, and attenuating barriers
Inhalation
Endpoint:
Death
AerosolAlpha, beta, gammaInternal body contamination, effect depends on the source strength and decay
Inhalation
Endpoint:
Cancer or organ damage
Aerosol Cancer or organ damage
DermalAerosolAlpha, beta, gammaDose dependent on source strength
ParenteralSolid particlesAlpha, beta, gammaInternal body contamination, the effect depends on the source strength and decay
Physically damaging CBRNE
Physical formType of reactionEnergy delivery formHealth effects
Gas, liquid, solidHighly reactive with waterFlame, heatSkin burns
internal burns
Gas, vapor, solidSelf-reactingExplosion, projection, fireMechanical fragmentation burns
Solid, liquidSelf-reaction,
Reaction upon ignition or exposure to air
Explosion; fireMechanical fragmentation burns
Table 6. Integration of chemical and energetic hazards with communicative symbols and hazard descriptors. 1 For code definition, see Regulation 1272/2008 [22], 2 also, corrosion of any other tissue. 3 CBRN-related: lungs, skin, upper respiratory tract, heart, blood. Description of hazard statements [H]. Format: HXYZ. X (2) physical hazard; (3) health hazard, (4) environmental hazard. Y route of exposure [0]—ingestion; (1)—dermal, (3)—inhalation (7) internal organ damage. Z action/severity (0–2) toxicity (fatal, toxic), (3,5)—other (damage, sensitizing, irritation).
Table 6. Integration of chemical and energetic hazards with communicative symbols and hazard descriptors. 1 For code definition, see Regulation 1272/2008 [22], 2 also, corrosion of any other tissue. 3 CBRN-related: lungs, skin, upper respiratory tract, heart, blood. Description of hazard statements [H]. Format: HXYZ. X (2) physical hazard; (3) health hazard, (4) environmental hazard. Y route of exposure [0]—ingestion; (1)—dermal, (3)—inhalation (7) internal organ damage. Z action/severity (0–2) toxicity (fatal, toxic), (3,5)—other (damage, sensitizing, irritation).
HazardEffects DescriptionGHS Hazard Codes 1Pictograms
GHS-based
Health hazards
HazardDescriptionHazard statementPictogram
EffectAction
Acute toxicityFatal
POISO-NINGH300, H310, H330
Skull and bones
Toxic
H301, H311, H331
Skull and bones
HarmfulH302, H312, H332Exclamation mark
Corrosion 2 skin/eye damage
Irritation skin/eye
Severe
Burns
Irritation
TISSUE DAMAGE
CHEMICAL
BURNS
H314, H318

H315, H319
Dripping acid

Exclamation mark
Respiratory/skin sensitizationMay cause
allergy, asthma, breathing difficulties
SENSITI-ZINGH334


Health hazard


H317Exclamation mark
Selective target Organ Toxicity—Single exposureCauses damage
to (organ) 3
TOXIC TO TARGET ORGANH370

Health hazard

May cause…
damage
to organ…
H371

H335
Exclamation mark
Physical hazards
ExplosiveUnstable

PHYSICAL DAMAGE



H200 to H204



Exploding bomb
Mass explosion
Severe projection
Fire, blast or explosion
FlammableExtremely
flammable gas




HEAT BURNS
H220






Flame over the surface
Pyrophoric


H250
Emitting flammable
gases in contact
with water

H251

Self-heatingH252
Other reactive
Self-reactive


Heating may
cause
explosion/fire

May cause
fire/explosion

May intensify fire

PHYSICAL DAMAGE



H240–H242



Exploding bomb or flame over a surface

Pyrophoric
Peroxides
Oxidizers
CHEMICAL BURNSH271,
H272
Flame over circle
Non-GHS based
Weaponized CWA Nerve agents
Blister agents
Choking agents
Blood-poisoning agents
Psychoactive agents
Incapacitating agents
Corresponding to GHS
H330,
H310
H300
Also
H350, H370
Three-pronged black or red shape in a trefoil on yellow
Biological hazards
AllNo standardized effect descriptionsNo symbolic hazard levelsBlack triple crescent in a trefoil on yellow
Radiological/Nuclear hazard
Ionizing radiationGeneral Text:
Warning;
Radioactive material or ionizing radiation + Black trefoil in a yellow circle (ISO 361 standardized)
High-level sealed-source ionizing radiationBlack trefoil with rays emitting on a skull and a running figure
Any transported radiation-emitting materialDiamond with a text:
“Radioactive”
Transported fissile material “diamond with a text
“Fissile”
Table 7. List of CBRN relevant properties and features for each of the CBRN domains.
Table 7. List of CBRN relevant properties and features for each of the CBRN domains.
Properties and Features Satisfying the CBRN Information Needs
SubdomainExisting classificationsLooked for in CBRN
ChemicalEndpoint: death, damage, asthma/allergy, selective target organ toxicityEndpoint: death, damage, asthma/allergy, selective target organ toxicity
Physical, chemical propertiesPhysical, chemical, and senses-determined (olfactory, visible)
Route of exposure: inhalation, skin/ocular, ingestionInhalation, skin/ocular, ingestion, parenteral
SymptomsManifestations, severity, onset
BiologicalEndpoint: individual: death, hospitalization,
population: epidemic, pandemic
Endpoint: death, hospitalization
Virulence: LD50 median lethal dose, ID50 median infectious dose, R0 threshold for herd immunityRoute of exposure: inhalation, ingestion, direct
Pathogenicity Transmissibility
Treatment/remediesBehavioral remedies
AlertRapid, days, weeks
Radiological/Nuc-learEndpoint: Death, cancer, or organ damageEndpoint: Death, cancer, or organ damage
Energy:
equivalent dose, effective dose
Energy:
equivalent dose, effective dose
Target organ
Decay: in relation to absorbed corpuscular radioactive matter
Attenuation: attenuation factors
Exposure routes: direct irradiation, inhalation, ingestion, parenteral
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Gorniak, L.; Cichon, N.; Stela, M.; Niemcewicz, M.; Podogrocki, M.; Siadkowski, A.; Ceremuga, M.; Bijak, M. A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters. Appl. Sci. 2025, 15, 10421. https://doi.org/10.3390/app151910421

AMA Style

Gorniak L, Cichon N, Stela M, Niemcewicz M, Podogrocki M, Siadkowski A, Ceremuga M, Bijak M. A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters. Applied Sciences. 2025; 15(19):10421. https://doi.org/10.3390/app151910421

Chicago/Turabian Style

Gorniak, Leslaw, Natalia Cichon, Maksymilian Stela, Marcin Niemcewicz, Marcin Podogrocki, Adrian Siadkowski, Michal Ceremuga, and Michal Bijak. 2025. "A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters" Applied Sciences 15, no. 19: 10421. https://doi.org/10.3390/app151910421

APA Style

Gorniak, L., Cichon, N., Stela, M., Niemcewicz, M., Podogrocki, M., Siadkowski, A., Ceremuga, M., & Bijak, M. (2025). A Practical Classification Approach for Chemical, Biological, Radiological and Nuclear (CBRN) Hazards Based on Toxicological and Situational Parameters. Applied Sciences, 15(19), 10421. https://doi.org/10.3390/app151910421

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