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Volume 15
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10.3390/app15105357
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Systematic Review

The Application of Local Doxycycline Gel for the Nonsurgical Treatment of Peri-Implant Diseases: A Systematic Review of the Literature

by
Stefano Corbella
1,2,*,
Alex Vendrame
1,2,
Lucia Tedeschi
1,2,
Igor Ashurko
3 and
Luca Francetti
1,2
1
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, 20122 Milan, Italy
2
IRCCS Ospedale Galeazzi Sant’Ambrogio, 20157 Milan, Italy
3
Department of Oral Surgery, Institute of Dentistry, I.M. Sechenov First Moscow State Medical Univesity (Sechenov University), 119048 Moscow, Russia
*
Author to whom correspondence should be addressed.
Appl. Sci. 2025, 15(10), 5357; https://doi.org/10.3390/app15105357
Submission received: 8 April 2025 / Revised: 27 April 2025 / Accepted: 9 May 2025 / Published: 11 May 2025
(This article belongs to the Special Issue Implant Dentistry: Advanced Materials, Methods and Technologies)
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Featured Application

The application of local doxycycline gel for the nonsurgical treatment of peri-implantitis showed promising results, although further scientific validation is needed.

Abstract

Doxycycline is an antibiotic belonging to the tetracycline family. Although systematic reviews do not recommend the local administration of antibiotics in association with mechanical instrumentation for the treatment of peri-implant diseases, none of these studies refer to the use of locally derived doxycycline. The aim of this systematic review is to evaluate the efficacy of the local application of doxycycline gel in the treatment of peri-implant diseases. The protocol of the review was submitted in PROSPERO. The manuscript was organized and prepared following the PRISMA guidelines and the systematic review was conducted according to the Cochrane Handbook for Systematic Review of Interventions—Second Edition. MEDLINE through OVID interface, EMBASE and Cochrane Central were interrogated for article research. The OpenGrey search engine was used for grey literature. Three articles were included in the review, involving 69 patients and 123 implants. None of these studies reported adverse events or complications during the observation period. In conclusion, the evidence about the local administration of doxycycline is not enough to provide a clinical recommendation; however, the results of the study and the biological plausibility of the potential advantages of the use of such antibiotics for the treatment of peri-implant diseases should stimulate further research.
Keywords: antibiotic; doxycycline; dental implant; peri-implant; peri-implant disease; peri-implant mucositis; peri-implantitis antibiotic; doxycycline; dental implant; peri-implant; peri-implant disease; peri-implant mucositis; peri-implantitis

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MDPI and ACS Style

Corbella, S.; Vendrame, A.; Tedeschi, L.; Ashurko, I.; Francetti, L. The Application of Local Doxycycline Gel for the Nonsurgical Treatment of Peri-Implant Diseases: A Systematic Review of the Literature. Appl. Sci. 2025, 15, 5357. https://doi.org/10.3390/app15105357

AMA Style

Corbella S, Vendrame A, Tedeschi L, Ashurko I, Francetti L. The Application of Local Doxycycline Gel for the Nonsurgical Treatment of Peri-Implant Diseases: A Systematic Review of the Literature. Applied Sciences. 2025; 15(10):5357. https://doi.org/10.3390/app15105357

Chicago/Turabian Style

Corbella, Stefano, Alex Vendrame, Lucia Tedeschi, Igor Ashurko, and Luca Francetti. 2025. "The Application of Local Doxycycline Gel for the Nonsurgical Treatment of Peri-Implant Diseases: A Systematic Review of the Literature" Applied Sciences 15, no. 10: 5357. https://doi.org/10.3390/app15105357

APA Style

Corbella, S., Vendrame, A., Tedeschi, L., Ashurko, I., & Francetti, L. (2025). The Application of Local Doxycycline Gel for the Nonsurgical Treatment of Peri-Implant Diseases: A Systematic Review of the Literature. Applied Sciences, 15(10), 5357. https://doi.org/10.3390/app15105357

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