Changes in Skeletal Muscle Atrophy over Time in a Rat Model of Adenine-Induced Chronic Kidney Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Model and Experimental Design
2.2. Tissue Preparation
2.3. Histological Analysis of Muscle and Kidney
2.4. Mitochondrial Activity
2.5. Gene Expression Analysis of Skeletal Muscle
2.6. Statistical Analyses
3. Results
3.1. Histological Findings and Cross-Sectional Area of Back Muscle
3.2. Mitochondrial Activity Evaluated with SDH Staining
3.3. Histological Sections of the Kidney
3.4. Gene Expression of Skeletal Muscle
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Okamoto, K.; Kasukawa, Y.; Nozaka, K.; Tsuchie, H.; Kudo, D.; Kinoshita, H.; Ono, Y.; Igarashi, S.; Kasama, F.; Harata, S.; et al. Changes in Skeletal Muscle Atrophy over Time in a Rat Model of Adenine-Induced Chronic Kidney Disease. Appl. Sci. 2024, 14, 9106. https://doi.org/10.3390/app14199106
Okamoto K, Kasukawa Y, Nozaka K, Tsuchie H, Kudo D, Kinoshita H, Ono Y, Igarashi S, Kasama F, Harata S, et al. Changes in Skeletal Muscle Atrophy over Time in a Rat Model of Adenine-Induced Chronic Kidney Disease. Applied Sciences. 2024; 14(19):9106. https://doi.org/10.3390/app14199106
Chicago/Turabian StyleOkamoto, Kento, Yuji Kasukawa, Koji Nozaka, Hiroyuki Tsuchie, Daisuke Kudo, Hayato Kinoshita, Yuichi Ono, Shun Igarashi, Fumihito Kasama, Shuntaro Harata, and et al. 2024. "Changes in Skeletal Muscle Atrophy over Time in a Rat Model of Adenine-Induced Chronic Kidney Disease" Applied Sciences 14, no. 19: 9106. https://doi.org/10.3390/app14199106
APA StyleOkamoto, K., Kasukawa, Y., Nozaka, K., Tsuchie, H., Kudo, D., Kinoshita, H., Ono, Y., Igarashi, S., Kasama, F., Harata, S., Oya, K., Kawaragi, T., Tominaga, K., Watanabe, M., & Miyakoshi, N. (2024). Changes in Skeletal Muscle Atrophy over Time in a Rat Model of Adenine-Induced Chronic Kidney Disease. Applied Sciences, 14(19), 9106. https://doi.org/10.3390/app14199106