Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver
Abstract
:1. Introduction
2. Materials and Methods
2.1. Aflatoxin
2.2. Plant Materials
2.3. Test for Detoxification of AFB1 Using Medicinal Plant Extracts
2.4. Analysis of Degraded AFB1 Products
2.5. Brine Shrimp Lethality Assay
2.6. Preparation of Plant Extracts
2.7. Antioxidant Potential of Plant Extracts
2.8. Mouse Assay Experiments
2.9. Mouse Sacrifice
2.10. Biochemical Tests
2.11. Histopathological Studies
2.12. Statistical Analysis
3. Results
3.1. Screening of Medicinal Plants for AFB1 Detoxification
3.2. LC/MS Analysis of Degraded AFB1 Products
3.3. Brine Shrimp Lethality Assay
3.4. DPPH Measurements
3.5. Body Weight of Mice
3.6. AFB1-Induced Oxidative Stress
3.7. Histopathological Studies
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Name of the Plant | Family | Accession Number | AFB1 Detoxification (%) |
---|---|---|---|
Aerva javanica (Burm.f.) Juss. ex Schult. | Amaranthaceae | 201800506 | 33 |
Searsia aucheri (Boiss.) Moffett | Anacardiaceae | 201800777 | 0 |
Desmidorchis adenensis (Deflers) Meve & Liede | Apocynaceae | 200604436 | 6 |
Desmidorchis arabica (N.E.Br.) Meve & Liede | Apocynaceae | 201800303 | 0 |
Desmidorchis flava (N.E.Br.) Meve & Liede | Apocynaceae | 201300308 | 32 |
Desmidorchis penicillata (Deflers) Plowes | Apocynaceae | 201800596 | 0 |
Monolluma quadrangular (Forssk.) Plowes | Apocynaceae | 201800011 | 55 |
Aloe dhufarensis Lavranos | Asphodelaceae | 201000386 | 32 |
Aloe praetermissa T.A.McCoy & Lavranos | Asphodelaceae | 201000250 | 0 |
Aloe vera (L.) Burm.f. | Asphodelaceae | 201800270 | 10 |
Kleinia odora (Forssk.) DC. | Asteraceae | 201000077 | 85 |
Pluchea arabica (Boiss.) Qaiser & Lack | Asteraceae | 201000388 | 58 |
Pulicaria glutinosa (Boiss.) Jaub. & Spach | Asteraceae | 201200418 | 40 |
Tecomella undulata (Sm.) Seem. | Bignoniaceae | 200817492 | 85 |
Heliotropium bacciferum Forssk. | Boraginaceae | 201600290 | 95 |
Boswellia sacra Flück. | Burseraceae | 201300064 | 52 |
Commiphora gileadensis (L.) C. Christ. | Burseraceae | 201000695 | 18 |
Commiphora wightii (Arnott) Bhandari | Burseraceae | 200616808 | 16 |
Capparis cartilaginea Decne. | Capparaceae | 201001415 | 42 |
Capparis spinosa L. | Capparaceae | 201800536 | 22 |
Maerua crassifolia Forssk. | Capparaceae | 200602732 | 24 |
Ephedra ciliata Fisch. & C.A.Mey. | Ephedraceae | 201600189 | 88 |
Euphorbia aff. Uzmuk S.Carter & J.R.I.Wood | Euphorbiaceae | 200604709 | 21 |
Euphorbia larica Boiss. | Euphorbiaceae | 201800015 | 34 |
Euphorbia balsamifera subsp. adenensis (Deflers) P.R.O.Bally | Euphorbiaceae | 200717381 | 7 |
Euphorbia cactus Ehrenb. ex Boiss. | Euphorbiaceae | 201600143 | 0 |
Euphorbia smithii S.Carter | Euphorbiaceae | 201200704 | 32 |
Jatropha dhofarica Radcl.-Sm. | Euphorbiaceae | 201000400 | 10 |
Vachellia flava (Forssk.) Kyal. & Boatwr. | Fabaceae | 201900813 | 50 |
Prosopis cineraria (L.) Druce | Fabaceae | 200918235 | 8 |
Tephrosia purpurea subsp. apollinea (Delile) Hosni & El-Karemy | Fabaceae | 201900065 | 0 |
Tephrosia nubica (Bioss.) Baker | Fabaceae | 201900067 | 0 |
Lavandula dhofarensis subsp. ayunensis A.G. Mill. | Lamiaceae | 201800010 | 86 |
Lavandula subnuda Benth. | Lamiaceae | 201900964 | 81 |
Ocimum dhofarense (Sebald) A.J.Paton | Lamiaceae | 202000071 | 93 |
Coleus barbatus (Andrews) Benth. ex G.Don | Lamiaceae | 201600466 | 70 |
Coleus cylindraceus (Hochst. ex Benth.) A.J.Paton | Lamiaceae | 201800554 | 9 |
Salvia hillcoatiae Hedge | Lamiaceae | 201900818 | 84 |
Teucrium nummularifolium Baker | Lamiaceae | 201800146 | 62 |
Teucrium stocksianum subsp. stenophyllum R.A.King | Lamiaceae | 201900997 | 22 |
Zataria multiflora Boiss. | Lamiaceae | 201100114 | 92 |
Indigofera articulata Gouan | Leguminosae | 201000765 | 60 |
Lawsonia inermis L. | Lythraceae | 200917997 | 35 |
Abutilon fruticosum Guill. & Perr. | Malvaceae | 201901182 | 0 |
Senra incana Cav. | Malvaceae | 201000211 | 0 |
Acridocarpus orientalis A.Juss. | Malpighiaceae | 201500463 | 0 |
Moringa peregrina (Forssk.) Fiori | Moringaceae | 200609782 | 8 |
Myrtus communis L. | Myrtaceae | 201500311 | 0 |
Olea europaea subsp. cuspidate (Wall. & G.Don) Cif. | Oleaceae | 200717412 | 0 |
Schweinfurthia spinosa A.G.Mill., M.Short & D.A.Sutton | Plantaginaceae | 201800698 | 34 |
Dionysia mira (Jaub. & Spach.) Wendelbo | Primulaceae | 201800663 | 33 |
Ochradenus arabicus Chaudhary, Hillc. & A.G. Mill. | Resedaceae | 201900726 | 35 |
Ziziphus spina-christi (L.) Desf. | Rhamnaceae | 200817484 | 71 |
Hyoscyamus gallagheri A.G.Mill. & Biagi | Solanaceae | 201900407 | 35 |
Hermannia paniculata Franch. | Sterculiaceae | 201900552 | 15 |
Zygophyllum luntii (Baker) Christenh. & Byng | Zygophylaceae | 201901077 | 0 |
Zygophyllum paulayanum (J.Wagner & Vierth.) Christenh. & Byng | Zygophylaceae | 201800475 | 0 |
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Velazhahan, R.; Al-Sadi, A.M.; Waly, M.I.; Soundra Pandian, S.B.; Al-Sabahi, J.; Al-Farsi, K. Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver. Appl. Sci. 2024, 14, 5378. https://doi.org/10.3390/app14135378
Velazhahan R, Al-Sadi AM, Waly MI, Soundra Pandian SB, Al-Sabahi J, Al-Farsi K. Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver. Applied Sciences. 2024; 14(13):5378. https://doi.org/10.3390/app14135378
Chicago/Turabian StyleVelazhahan, Rethinasamy, Abdullah Mohammed Al-Sadi, Mostafa I. Waly, Sathish Babu Soundra Pandian, Jamal Al-Sabahi, and Khalid Al-Farsi. 2024. "Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver" Applied Sciences 14, no. 13: 5378. https://doi.org/10.3390/app14135378
APA StyleVelazhahan, R., Al-Sadi, A. M., Waly, M. I., Soundra Pandian, S. B., Al-Sabahi, J., & Al-Farsi, K. (2024). Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver. Applied Sciences, 14(13), 5378. https://doi.org/10.3390/app14135378