Vardenafil Long-Term Administration Improves Episodic Memory in Aging Female Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals and Husbandry
2.2. Experimental Procedure
2.3. Elevated plus Maze (EPM) Test
2.4. Free Exploratory Test
2.5. Object Recognition Test (ORT)
2.6. Drug Preparation and Treatment
2.7. Statistical Analysis
3. Results
3.1. Treatment with Vardenafil Does Not Affect Anxiety-like Behaviors and Locomotor Activity in Aged Female Mice
3.2. Vardenafil Improves Object Recognition in Aged Female Mice
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Vehicle a | Vardenafil b | |
---|---|---|
e1 | 22.57 (4.44) | 21.11 (2.56) |
e2 | 20.14 (3.68) | 24.43 (3.15) |
e3 | 30.25 (7.10) | 40.86 (2.74) |
h1 | 2.43 (3.76) | −3.32 (3.35) |
h24 | −7.68 (5.08) | −19.75 (4.28) |
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Dadomo, H.; Ponzi, D.; Paterlini, S.; Parmigiani, S.; Palanza, P. Vardenafil Long-Term Administration Improves Episodic Memory in Aging Female Mice. Appl. Sci. 2023, 13, 12470. https://doi.org/10.3390/app132212470
Dadomo H, Ponzi D, Paterlini S, Parmigiani S, Palanza P. Vardenafil Long-Term Administration Improves Episodic Memory in Aging Female Mice. Applied Sciences. 2023; 13(22):12470. https://doi.org/10.3390/app132212470
Chicago/Turabian StyleDadomo, Harold, Davide Ponzi, Silvia Paterlini, Stefano Parmigiani, and Paola Palanza. 2023. "Vardenafil Long-Term Administration Improves Episodic Memory in Aging Female Mice" Applied Sciences 13, no. 22: 12470. https://doi.org/10.3390/app132212470
APA StyleDadomo, H., Ponzi, D., Paterlini, S., Parmigiani, S., & Palanza, P. (2023). Vardenafil Long-Term Administration Improves Episodic Memory in Aging Female Mice. Applied Sciences, 13(22), 12470. https://doi.org/10.3390/app132212470