A Look at the Importance of Chirality in Drug Activity: Some Significative Examples
, Domenico Iacopetta 1, Angelica Franchini 2, Michele De Luca 1, Carmela Saturnino 3, Inmaculada Andreu 4,5, Maria Stefania Sinicropi 1,* and Alessia Catalano 2Round 1
Reviewer 1 Report
Comments for author File: 
Comments.pdf
Author Response
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Reviewer 2 Report
send separately
Comments for author File: 
Comments.docx
Author Response
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Reviewer 3 Report
In the paper” a Flash on the importance OF Chirality in Drug Activity: Some Significative examples” by Ceramella et al. the Authors offer an overview of the activity of chiral drugs, with an emphasis on the effect of stereochemistry on drug action.
However, for some pf the reported drugs there is no indication of stereochemical effect, mostly because the enantiomer of the drug under use is not available. My advice is to remove those examples from the review , as they add no further knowledge on the subject (e,g, angiotensin-converting enzyme inhibitors, orciprenaline, astragalin, some of the anticancer drugs listed in chapter 9, and JAK inhibitors).
Author Response
The responses are in the attached file
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
The extensive revised version has been conducted in a short time. The paper and the table has been improved and can thus be published as is.
