Diagnostic Strategies for Urologic Cancer Using Expression Analysis of Various Oncogenic Surveillance Molecules—From Non-Coding Small RNAs to Cancer-Specific Proteins
Round 1
Reviewer 1 Report
Dear Authors, I suggest you to read the MS carefully, for grammatical errors. Figures are not good. figures seem to be flowchart rather catchy cell signaling based. You should show in figures what are the cell signaling molecules that are modulated by the MiRNA and thereafter growth of tumor may stop. Need to improve the conclusion section.
Author Response
We thank you for the opportunity to resubmit our manuscript to the Applied sciences.
We have revised the manuscript according to the reviewers' comments and resubmit it for consideration for publication in Applied sciences.
We hope that is now suitable for publication.
The details of the revisions and responses to the reviewers’ comments as follows;
Dear Authors, I suggest you to read the MS carefully, for grammatical errors. Figures are not good. figures seem to be flowchart rather catchy cell signaling based. You should show in figures what are the cell signaling molecules that are modulated by the MiRNA and thereafter growth of tumor may stop. Need to improve the conclusion section.
Thank you for reviewer’s comments.
This manuscript will be revised by us and then submitted for English editing. It will be revised by a native English speaker.
Specific miRNAs, their targets, and their general functions have been added to Figure 4.
In addition, we have created a list of miRNAs and associated tumors that are potential biomarker candidates as Table 1.
Reviewer 2 Report
“Diagnostic Strategies for Urologic Cancer Using Expression Analysis of Various Oncogenic Surveillance Molecules-From non-cording small RNAs to cancer-specific proteins” by Tomomi Fujii et al describes the essential role of micro-RNA in cancer biology, especially in genitourinary cancers, not included testis cancer. This is a clearly presented straight-review study. The manuscript is written carefully. However, the authors should clarify some issues before the manuscript is ready for publishing.
1. The authors did not mention any specific micro-RNAs which are potentially therapeutic targeted treatments or predicted makers for patients with genitourinary cancer.
2. The manuscript should have a conclusion paragraph.
Author Response
We thank you for the opportunity to resubmit our manuscript to the Applied sciences.
We have revised the manuscript according to the reviewers' comments and resubmit it for consideration for publication in Applied sciences.
We hope that is now suitable for publication.
The details of the revisions and responses to the reviewers’ comments as follows;
- The authors did not mention any specific micro-RNAs which are potentially therapeutic targeted treatments or predicted makers for patients with genitourinary cancer.
Thank you for reviewer’s comments.
Specific miRNAs, their targets, and their general functions have been added to Figure 4.
In addition, we have created a list of miRNAs and associated tumors that are potential biomarker candidates as Table 1.
- The manuscript should have a conclusion paragraph.
Thank you for reviewer’s comments.
The conclusion has been added as paragraph 5.
Reviewer 3 Report
miRNAs represent group of clinically important analytes and methods for their determination are promising tools in the diagnostic. The topics of the manuscript is suitable for the applied sciences. Nevertheless, quality manuscript should be significantly improved. The authors present miRNAs as a functionally uniform group without further characterization / identification. The text should make it clear which miRNA is being discussed. I would also like to recommend, incorporation table for miRNAs summarization (e.g., name, role in the oncogenesis, regulated genes) into manuscript.
Minor
Figure 1 The term “oncological diseases” should be used instead “cancer”
Author Response
We thank you for the opportunity to resubmit our manuscript to the Applied sciences.
We have revised the manuscript according to the reviewers' comments and resubmit it for consideration for publication in Applied sciences.
We hope that is now suitable for publication.
The details of the revisions and responses to the reviewers’ comments as follows;
miRNAs represent group of clinically important analytes and methods for their determination are promising tools in the diagnostic. The topics of the manuscript is suitable for the applied sciences. Nevertheless, quality manuscript should be significantly improved. The authors present miRNAs as a functionally uniform group without further characterization / identification. The text should make it clear which miRNA is being discussed. I would also like to recommend, incorporation table for miRNAs summarization (e.g., name, role in the oncogenesis, regulated genes) into manuscript.
Thank you for reviewer’s comments.
Specific miRNAs, their targets, and their general functions have been added to Figure 4.
In addition, we have created a list of miRNAs and associated tumors that are potential biomarker candidates as Table 1.
Minor
Figure 1 The term “oncological diseases” should be used instead “cancer”
Thank you for reviewer’s comments.
The term “oncological diseases” was rewritten instead “cancer” in Figure 1
Round 2
Reviewer 1 Report
Most of my concerns are added. Therefore, accept this paper for possible publication.
Reviewer 3 Report
I have no objection.
