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Applied Sciences
Volume 12
Issue 1
10.3390/app12010306
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Article
Peer-Review Record

Prognostic Significance of SATB1, SMAD3, Ezrin and β-Catenin in Patients with Pancreatic Adenocarcinoma

Appl. Sci. 2022, 12(1), 306; https://doi.org/10.3390/app12010306
by Justyna Durślewicz 1,*, Anna Klimaszewska-Wiśniewska 1, Ewa Domanowska 1, Natalia Skoczylas-Makowska 1, Paulina Antosik 1, Wioletta Zielińska 2, Arkadiusz Gzil 1, Paulina Czajkowska 2, Klaudia Mikołajczyk 2 and Dariusz Grzanka 1
Reviewer 1:
Muhammad R. Haque
Reviewer 2: Anonymous
Appl. Sci. 2022, 12(1), 306; https://doi.org/10.3390/app12010306
Submission received: 9 November 2021 / Revised: 16 December 2021 / Accepted: 23 December 2021 / Published: 29 December 2021
(This article belongs to the Special Issue Recent Developments and Emerging Trends in Cytoskeletal and Cell Cycle Proteins)

Round 1

Reviewer 1 Report

The authors explored the prognostic value of the expressions of SATB1, SMAD3, Ezrin, and beta-catenin in Pancreatic Ductal Adenocarcinoma. By checking the protein expression and mRNA expression levels, they concluded their hypothesis that either single or combined and expression of these markers are helpful in predicting PDAC. The MM is detailed, results are backed by enough data, and the conclusion is supported by the results. I'd give the article a pass with minor english and grammar checking. 

Author Response

Thank you for your time and positive comments on our manuscript. We have carefully proofread our manuscript and have made the grammar corrections, sincerely hoping it will meet with your requirement.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript entitled "Prognostic significance of SATB1, SMAD3, Ezrin and β-catenin in patients with pancreatic adenocarcinoma” tratta di un argomoneto molto interessate, l’adenocarcinoma pancreatico è un tumore ggressivo di difficile diagnosi e avvolta quando questa avviene risulta non efficace.

Contemporanemente la necessità di individuare nuovi biomarkers è sempre più necessaria.

Il lavoro è bene strutturato, lo scopo è chiaro.

Le metodiche utilizzate sono adeguate e la letteratura è giusta.

Tuttavia ho un suggerimento per gli autori:

è noto che la metilazione, cfDNA e diagnosi rapide e veloci sono essenziali per questo tipo di cancro; pertanto sarebbe interessante aggiungere una riflessione sullo stato di metilazione di questi marcatori e se attraverso l’impiego del cfDNA si potessero individuare dei loro cambiamenti ancora più precoci.

Suggerisco questo lavoro doi: 10.3390/genes11010014.

Author Response

Thank you very much for the review of our manuscript. Undoubtedly, DNA methylation signatures have great potential as molecular biomarkers to guide clinical management of PDAC. However, it appears to be beyond the scope of our study.The authors have chosen not to make a suggested change to the research paper.

Author Response File: Author Response.docx

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