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Article

Protective Effect and Potential Antioxidant Role of Kakadu Plum Extracts on Alcohol-Induced Oxidative Damage in HepG2 Cells

1
Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si 17104, Gyeonggi-do, Korea
2
Department of Oriental Medicinal Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si 17104, Gyeonggi-do, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Dasha Mihaylova and Ivelina Desseva
Appl. Sci. 2022, 12(1), 236; https://doi.org/10.3390/app12010236
Received: 6 December 2021 / Revised: 20 December 2021 / Accepted: 23 December 2021 / Published: 27 December 2021
Serial alcohol consumption causes alcoholic liver disease (ALD), which can lead to fatty liver, hepatitis, and cirrhosis. Terminalia ferdinandiana (Kakadu plum) is an indigenous fruit of Australia, which is utilized as a functional food. It is a commercially important antioxidant as it contains a more eloquent level of ascorbic acid than other oranges. In this study, we analyzed the chemical constituents of vitamin C, gallic acid, ellagic acid, and daidzin via High-performance liquid chromatography (HPLC) in the Kakadu plum from two different regions including the Northern Territory (NT) and Western Australia (WA), and compared their biochemical properties. The vitamin C content was much higher (almost 70%) in Kakadu plum (KKD) from the NT than WA. Moreover, ROS generation was inhibited significantly in HepG2 (human hepatoma) cells with the KKD-NT extract treatment when compared to the KKD-WA extract treatment. The cytotoxicity produced by ethanol was significantly suppressed in response to the treatment with both of the samples. In addition, our samples (KKD-NT and KKD-WA) increased the activity of two key enzymes involving alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) that metabolize ethanol. These results show the biochemical confirmation of the mechanism by which KKD exhibits its biological functions including relief from alcohol hangovers as well as protection of the liver cells by the suppression of ROS production and toxic insults. View Full-Text
Keywords: Kakadu plum; ethanol metabolism; liver; toxicity; ROS generation Kakadu plum; ethanol metabolism; liver; toxicity; ROS generation
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MDPI and ACS Style

Akter, R.; Kwak, G.-Y.; Ahn, J.C.; Mathiyalagan, R.; Ramadhania, Z.M.; Yang, D.C.; Kang, S.C. Protective Effect and Potential Antioxidant Role of Kakadu Plum Extracts on Alcohol-Induced Oxidative Damage in HepG2 Cells. Appl. Sci. 2022, 12, 236. https://doi.org/10.3390/app12010236

AMA Style

Akter R, Kwak G-Y, Ahn JC, Mathiyalagan R, Ramadhania ZM, Yang DC, Kang SC. Protective Effect and Potential Antioxidant Role of Kakadu Plum Extracts on Alcohol-Induced Oxidative Damage in HepG2 Cells. Applied Sciences. 2022; 12(1):236. https://doi.org/10.3390/app12010236

Chicago/Turabian Style

Akter, Reshmi, Gi-Young Kwak, Jong Chan Ahn, Ramya Mathiyalagan, Zelika Mega Ramadhania, Deok Chun Yang, and Se Chan Kang. 2022. "Protective Effect and Potential Antioxidant Role of Kakadu Plum Extracts on Alcohol-Induced Oxidative Damage in HepG2 Cells" Applied Sciences 12, no. 1: 236. https://doi.org/10.3390/app12010236

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