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Article

Microfluidic Platform for Examination of Effect of Chewing Xylitol Gum on Salivary pH, O2, and CO2

1
BioSense Institute, University of Novi Sad, 21000 Novi Sad, Serbia
2
Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia
3
Faculty of Technical Sciences, University of Novi Sad, 21000 Novi Sad, Serbia
*
Author to whom correspondence should be addressed.
Academic Editor: Bruno Chrcanovic
Appl. Sci. 2021, 11(5), 2049; https://doi.org/10.3390/app11052049
Received: 22 December 2020 / Revised: 13 January 2021 / Accepted: 25 January 2021 / Published: 26 February 2021
(This article belongs to the Special Issue Applied Sciences in Dentistry)
Miniaturization of different measurement processes and a scaled-down approach open the possibility for rapid measurements with the small amounts of samples and reagents into a compact platform with integrated sensors and different measuring components. In this paper, we report a microfluidic approach for measurements of salivary pH, dissolved O2, and CO2 during chewing xylitol gum. The study was done with the samples of 30 healthy volunteers who were chewing a xylitol gum, and the measurements were performed in the microfluidic (MF) chip with integrated commercial PreSens sensors. Xylitol exhibited a significant effect on the pH of saliva in terms of its initial drop, which was the most significant between the 5th and 10th minutes. The effect of xylitol on the amount of oxygen and carbon dioxide in saliva cannot be confirmed. The employed microfluidic platform was shown to be applicable and effective in the analysis of salivary biomarkers relevant to caries development. View Full-Text
Keywords: microfluidics; saliva; pH; O2; CO2; xylitol; PMMA; xurography microfluidics; saliva; pH; O2; CO2; xylitol; PMMA; xurography
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MDPI and ACS Style

Podunavac, I.; Hinić, S.; Kojić, S.; Jelenčiakova, N.; Radonić, V.; Petrović, B.; Stojanović, G.M. Microfluidic Platform for Examination of Effect of Chewing Xylitol Gum on Salivary pH, O2, and CO2. Appl. Sci. 2021, 11, 2049. https://doi.org/10.3390/app11052049

AMA Style

Podunavac I, Hinić S, Kojić S, Jelenčiakova N, Radonić V, Petrović B, Stojanović GM. Microfluidic Platform for Examination of Effect of Chewing Xylitol Gum on Salivary pH, O2, and CO2. Applied Sciences. 2021; 11(5):2049. https://doi.org/10.3390/app11052049

Chicago/Turabian Style

Podunavac, Ivana, Stevan Hinić, Sanja Kojić, Nina Jelenčiakova, Vasa Radonić, Bojan Petrović, and Goran M. Stojanović. 2021. "Microfluidic Platform for Examination of Effect of Chewing Xylitol Gum on Salivary pH, O2, and CO2" Applied Sciences 11, no. 5: 2049. https://doi.org/10.3390/app11052049

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