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Article

Global Repigmentation Strategy of Grey Hair Follicles by Targeting Oxidative Stress and Stem Cells Protection

1
Givaudan France SAS, Route de Bazancourt, 51110 Pomacle, France
2
Givaudan France SAS, Bâtiment Canal Biotech 1, 3 Rue des Satellites, 31400 Toulouse, France
*
Author to whom correspondence should be addressed.
Appl. Sci. 2021, 11(4), 1533; https://doi.org/10.3390/app11041533
Received: 21 December 2020 / Revised: 25 January 2021 / Accepted: 2 February 2021 / Published: 8 February 2021
(This article belongs to the Special Issue Recent Advances in Hair Science)
One of the most visible signs of hair ageing is greying of the hair, also known as canities. This hair disorder is mainly caused by oxidative stress. In preliminary work, we designed various models mimicking the impact of oxidative stress on hair pigmentation, showing an accumulation of reactive oxygen species (ROS) production and a decrease in the presence of melanocytes and melanoblasts, resulting in a decrease in hair pigmentation. A proteomic study on skin scalp explants was performed to identify the dysregulated biological pathways related to canities. We developed a smart active ingredient which has been tested on these biological pathways. We demonstrated that these negative effects were rectified in the presence of the ingredient, showing a reduction of ROS, protection of melanocyte reservoirs and reactivation of hair pigmentation. Finally, a clinical study was carried out on a panel of 44 male volunteers with grey hair. After 4 months, we evidenced a reduction in the proportion of grey hair and in the number of grey hairs/cm2 relative to Day 0. In conclusion, we clearly evidenced that oxidative stress is a key factor in triggering a cascade of events leading to a loss of hair pigmentation. We developed this active ingredient which is capable of restoring all the disrupted mechanisms and of providing hair repigmentation within only 4 months. View Full-Text
Keywords: canities; oxidative stress; hair follicles; active ingredient canities; oxidative stress; hair follicles; active ingredient
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MDPI and ACS Style

De Tollenaere, M.; Chapuis, E.; Auriol, P.; Auriol, D.; Scandolera, A.; Reynaud, R. Global Repigmentation Strategy of Grey Hair Follicles by Targeting Oxidative Stress and Stem Cells Protection. Appl. Sci. 2021, 11, 1533. https://doi.org/10.3390/app11041533

AMA Style

De Tollenaere M, Chapuis E, Auriol P, Auriol D, Scandolera A, Reynaud R. Global Repigmentation Strategy of Grey Hair Follicles by Targeting Oxidative Stress and Stem Cells Protection. Applied Sciences. 2021; 11(4):1533. https://doi.org/10.3390/app11041533

Chicago/Turabian Style

De Tollenaere, Morgane, Emilie Chapuis, Pascale Auriol, Daniel Auriol, Amandine Scandolera, and Romain Reynaud. 2021. "Global Repigmentation Strategy of Grey Hair Follicles by Targeting Oxidative Stress and Stem Cells Protection" Applied Sciences 11, no. 4: 1533. https://doi.org/10.3390/app11041533

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