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Applied Sciences
Volume 11
Issue 3
10.3390/app11031161
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Article
Peer-Review Record

Cerebrovascular Reactivity Assessment during Carbon Dioxide Inhalation Using SPECT

Appl. Sci. 2021, 11(3), 1161; https://doi.org/10.3390/app11031161
by Yeong-Bae Lee 1,2 and Chang-Ki Kang 2,3,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Appl. Sci. 2021, 11(3), 1161; https://doi.org/10.3390/app11031161
Submission received: 14 December 2020 / Revised: 21 January 2021 / Accepted: 22 January 2021 / Published: 27 January 2021
(This article belongs to the Collection Advances of Biomedical Signal Processing for Disease Diagnosis, Prognosis or Severity Determination)

Round 1

Reviewer 1 Report

  1. Poor quality of figures 1 and 2. Please improve.
  2. Weak point of this work is that only 10 participants took part in the study with inequality of male and femal.
  3. Background to the study requires some amendments! Only 2 positions from 2020, one from 2019. It seems a little bit outdated.
  4. There is lack of section regarding further research plans, which would make this paper more interesting.
  5. Lack of section regarding study background of similar systems/solutions. 
  6. Overall a very good, solid work. Some amendments are however necessary.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The study is interesting and its showing a high potential to be of use in neurology/neurosurgery. However, it is hard to see exactly how significant are the results for clinical practice, as this is not a case-control study (CO2 v ACZ, especially as in the  conclusions it is states that the method could be used as a substitute for ACZ, and as the study group is very low (only 10 subjects).

The clarity of the text could be improved, especially as the journal they have submitted the manuscript is a more general purpose journal, and not one specialized in imaging, making it difficult to follow for a non-specialist. 

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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