Understanding the Pattern of Oropharyngeal Cancers from North-East Romanian Patients
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
4.1. OPSCC HPV DNA Positive, p16, Risk Factors
4.2. OPSCC HPV DNA Positive and HPV RNA Positive
4.3. HPV DNA + HPV RNA + p16INK4a Over-Expression
4.4. HNSCC HPV Positive PIK3CA and FGFR Positive
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gender, Age | Risk Factors | ICD-O Code of the Primary Site | ICD-O Histology Code of the Primary Site | Size (mm) | Stage (TNM 2010) |
---|---|---|---|---|---|
HPV DNA 18 positive and HPV RNA 18 positive | |||||
Female, 54 | current smoker | C09 Tonsil | 8071/3, Squamous cell carcinoma, keratinizing, NOS * | 25 | T3, N1, Mx, composite stage III |
HPV DNA 16 positive and p16 positive | |||||
Male, 71 | unknown | C05.2 Uvula | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 2 | - |
Male, 41 | unknown | C01 Base of tongue | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 70 | N2 |
Male, 50 | unknown | C01 Base of tongue | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 80 | T3N2 |
Male, 48 | current smoker | C05.2 Uvula | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 30 | T2N1Mx |
HPV DNA 18 positive | |||||
Female, 54 | former smoker | C09 Tonsil | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 25 | T3N1M9 |
Male, 44 | current smoker | C10.9 Oropharynx, NOS | 8010/2, Carcinoma in situ, NOS | 35 | T4N1M0 |
HPV DNA 16 & 18 positive | |||||
Male, 61 | current smoker, alcohol consumer | C09 Tonsil | 8010/2, Carcinoma in situ, NOS | 70 | T4N3M0 |
HPV DNA 16 positive | |||||
Male, 47 | current smoker, alcohol consumer | C09 Tonsil | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 80 | T4N1M9 |
Male, 50 | smoker | C13.2 Posterior wall of hypopharynx | 8010/6, Carcinoma, metastatic, NOS | 50 | T3NXMXC3 |
Male, 66 | smoker | C01 Base of tongue | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 50 | T3N2M2 |
Male, 57 | current smoker, alcohol consumer | C09 Tonsil | 8010/3, Carcinoma, NOS | 20 | T2N1M9C3 |
Female, 70 | non smoker | C01 Base of tongue | 8071/3, Squamous cell carcinoma, keratinizing, NOS | - | T3N0M0 |
Male, 57 | current smoker, alcohol consumer | C10 Oropharynx | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 30 | T3N0M9 |
Male, 62 | unknown | C01 Base of tongue | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 20 | - |
Male, 72 | smoker | C01 Base of tongue | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 24 | T2N1MX |
Male, 55 | current smoker, alcohol consumer | C05.2 Uvula | 8071/3, Squamous cell carcinoma, keratinizing, NOS | 36 | T1N2M2 |
Male, 61 | unknown | C01 Base of tongue | 8010/2, Carcinoma in situ, NOS | 42 | T3N9M9C3 |
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Ursu, R.G.; Giusca, S.E.; Spiridon, I.A.; Manole, B.; Danciu, M.; Costan, V.V.; Palade, D.O.; Ghetu, N.; Toader, P.; Vlad, M.A.; et al. Understanding the Pattern of Oropharyngeal Cancers from North-East Romanian Patients. Appl. Sci. 2021, 11, 12079. https://doi.org/10.3390/app112412079
Ursu RG, Giusca SE, Spiridon IA, Manole B, Danciu M, Costan VV, Palade DO, Ghetu N, Toader P, Vlad MA, et al. Understanding the Pattern of Oropharyngeal Cancers from North-East Romanian Patients. Applied Sciences. 2021; 11(24):12079. https://doi.org/10.3390/app112412079
Chicago/Turabian StyleUrsu, Ramona Gabriela, Simona Eliza Giusca, Irene Alexandra Spiridon, Bianca Manole, Mihai Danciu, Victor Vlad Costan, Dragos Octavian Palade, Nicolae Ghetu, Paula Toader, Mădălina Alexandra Vlad, and et al. 2021. "Understanding the Pattern of Oropharyngeal Cancers from North-East Romanian Patients" Applied Sciences 11, no. 24: 12079. https://doi.org/10.3390/app112412079
APA StyleUrsu, R. G., Giusca, S. E., Spiridon, I. A., Manole, B., Danciu, M., Costan, V. V., Palade, D. O., Ghetu, N., Toader, P., Vlad, M. A., Damian, C., Porumb-Andrese, E., Luchian, I., & Iancu, L. S. (2021). Understanding the Pattern of Oropharyngeal Cancers from North-East Romanian Patients. Applied Sciences, 11(24), 12079. https://doi.org/10.3390/app112412079