EEG Changes Related to Gut Dysbiosis in Diabetes—Review
Round 1
Reviewer 1 Report
Accumulated evidence has suggested that the intestinal microbiota plays an important role in the pathogenesis of metabolic diseases as a potential novel contributor. In the present review, however, the author did not describe the contents regarding EEG changes related to gut dysbiosis in diabetes. Rather than gut dysbiosis, the author focused on EEG changes related to cognition in diabetes.
In addition, it is somewhat overstated that it is well established that vagus nerve stimulation induces EEG changes. Further, authors should describe the contents regarding more specific EEG changes and gut microbiota.
Author Response
Dear Reviewer,
Please see the point-by-point response in the attachemnt.
Thank you very much!
Author Response File: 
Author Response.pdf
Reviewer 2 Report
This manuscript reviews the studies on the relationship between changes of EEG signal rhythms and modification of intestinal microbiota profiles for diabetes. The novelty is clear, since these two concept are intuitively far-related. Various concepts are well presented for readers’ clarity. Below are the points for revision and improvement with each Section.
Abstract:
- Some texts needs polishing. For example (not limited to):
- “A clear association has been demonstrated between....” Please revise and polish this sentence, as it is verbose and unclear of focus.
- For the keywords ‘gut-brain axis’, it is not explicitly mentioned in the Abstract. Please clarity it, or substitute with more clear definitions.
Related Works:
- Need more references about EEG signal analysis:
- Peng, M. Nourani, J. Harvey and H. Dave, “Personalized feature selection for wearable EEG monitoring platform”, 20th IEEE international conference on bioinformatics and bioengineering (BIBE), October 2020. pp. 380-386.
Sec.1:
- Some texts needs polishing. For example (not limited to):
- “More importantly, increasing evidence suggests that......” Please divide the whole long sentence into several parts, with more clear expressions.
- “This is translatable to the human?” This sentence is grammatically wrong.
- It would be more concise to remove and to tailor some paragraphs. I am unaware of any necessity of mentioning stress in the whole paragraph 4. Please shorten this Section, by integrating and refining the key contents.
Sec. 2:
- Similarly, please shorten this Section by integrating and refining the key contents.
Consider dividing this Section into several subsections, related to (for reference only) (i) concepts and brief mechanism of microbiota-gut-brain axis, (ii) concepts and roles of VN (iii) recent trends on studies between VN and microbiota, in different disease cases.
Sec. 5:
- Please include potential future directions of such EEG- microbiota studies. For instance, what other diseases could be investigated on?
Author Response
Dear Reviewer,
Please see the point-by-point response in the attachemnt.
Thank you very much!
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
N/A
Author Response
Thank you very much for providing your valuable time and input to improve our manuscript. We appreciate your feedback.
Best regards!
