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Applied Sciences
Volume 11
Issue 24
10.3390/app112411621
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Review
Peer-Review Record

Viscosupplementation in the Therapy for Osteoarthritic Knee

Appl. Sci. 2021, 11(24), 11621; https://doi.org/10.3390/app112411621
by Junghyun Park 1, Hue Jung Park 2, Min Cheol Rho 2 and Jin Joo 2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Appl. Sci. 2021, 11(24), 11621; https://doi.org/10.3390/app112411621
Submission received: 25 October 2021 / Revised: 15 November 2021 / Accepted: 29 November 2021 / Published: 7 December 2021
(This article belongs to the Special Issue The Regenerative Engineering of Knee: From Biomaterials to Applications)

Round 1

Reviewer 1 Report

Well prepared and written material. Thank you for cumulative knowledge.

Author Response

Thank you for your compliment.

Reviewer 2 Report

The authors review intra-articular supplementation drugs for knee OA treatment. It is a meaningful work. However, there are some minor revisions needed to be settled in the manuscript as follows.

  1. Line 70-72: “Some review articles are negative about the efficacy of HA. However, there are more papers reporting the positive efficacy of HA positive.” What are the negative efficacy and positive efficacy? I suggest the authors show some details.
  2. Can authors classify the papers in the four tables and give short conclusions of the four tables? I think it will help readers understand the article.
  3. In Section Conclusion, it will be better if authors can give a suggestion that how to choose viscoelastic supplements based on their positive and adverse effects. There can be a brief comparison of HA, CLHA and PN/PDRN.

Author Response

Thank you very much your review and comment. 

The answer to your comment is in the uploaded file.

Author Response File: Author Response.docx

Reviewer 3 Report

Dear Authors, thank you for the opportunity to review the manuscript. 

Minor

1. The exclusion criteria should be described in detail 

2. Describe the scheme according to which the works were included in the analysis 

3. PubMed, PubMed Central, and Medline is a narrow search. Could there be a broader search? 

Author Response

Thank you for giving us the opportunity to submit a revised manuscript “Viscosupplementation in the therapy for osteoarthritic knee”.

Thank you for your review and comment.

We have tried to modify the manuscript based on your advice. (In the responses, we have distinguished the changes made by using blue-colored font)

  1. The exclusion criteria should be described in detail

->The exclusion criteria have been described (page 2).

 

  1. Describe the scheme according to which the works were included in the analysis

->The analysis was briefly described (page 2).

 

  1. PubMed, PubMed Central, and Medline is a narrow search. Could there be a broader search?

->We added google and google scholar to the search database (page 2 and main text). We are really sorry that we cannot put more databases in because the revision period is only 5 days. If we can get 2-3 months of additional time, we will add more databases to complete the paper.

Author Response File: Author Response.docx

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