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Article

Effect of Pulsed Electromagnetic Field Stimulation on the Growth Plate of the Tibia Bone of Rats: An In Vivo Study

1
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
2
EASYTEM Co., Ltd., Podowon-ro 116-gil, Siheung-si 14952, Korea
3
Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 34520, Korea
4
MN Co., Ltd., 14 Seongsui-ro 10-gil, Seongdong-gu, Seoul 04784, Korea
5
Department of Beauty Science, Kwangju Woman’s University, 40 Gwangjuyeodae-gil, Gwangsan-gu, Gwangju 62396, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Allen L. Garner, Raji Sundararajan and Ravi Joshi
Appl. Sci. 2021, 11(16), 7571; https://doi.org/10.3390/app11167571
Received: 1 July 2021 / Revised: 10 August 2021 / Accepted: 12 August 2021 / Published: 18 August 2021
(This article belongs to the Special Issue Biomedical Applications of Pulsed Power and Plasmas)
Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. Pulsed electromagnetic field (PEMF) stimulation induces cell proliferation of articular chondrocytes. We developed a method for growth promotion using equipment with PEMF. In this study, we aimed to evaluate the effects of PEMF on the growth rate of growth plates using an animal model. An experimental study was conducted on 16 3-week-old rats to validate the effects of the growth care device on growth and development by PEMF stimulation at 28 Hz and 20 Gauss. The tibia bones of the groups with and without PEMF administration were dissected after 10 days, and then, the length of the growth plate of the knee and levels of insulin-like growth factor (IGF)-1 hormone in serum were measured. The length of the growth plate on the tibia bone and the levels of circulating IGF-1 were significantly increased by 25.6% and 13.6%, respectively, in the experimental group to which PEMF was applied compared to those of the control group, without any side effects. These results suggest that PEMF can safely stimulate growth of the growth plate in a non-invasive manner to promote bone growth. View Full-Text
Keywords: bone growth; chondrocytes; growth care device; insulin-like growth factor-1; electromagnetic field bone growth; chondrocytes; growth care device; insulin-like growth factor-1; electromagnetic field
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MDPI and ACS Style

Sung, Y.-Y.; Shin, J.-W.; Yang, W.-K.; Kim, M.-J.; Koo, J.-I.; Noh, E.-M.; Min, K.-S.; Yun, M.-Y.; Kim, S.-H. Effect of Pulsed Electromagnetic Field Stimulation on the Growth Plate of the Tibia Bone of Rats: An In Vivo Study. Appl. Sci. 2021, 11, 7571. https://doi.org/10.3390/app11167571

AMA Style

Sung Y-Y, Shin J-W, Yang W-K, Kim M-J, Koo J-I, Noh E-M, Min K-S, Yun M-Y, Kim S-H. Effect of Pulsed Electromagnetic Field Stimulation on the Growth Plate of the Tibia Bone of Rats: An In Vivo Study. Applied Sciences. 2021; 11(16):7571. https://doi.org/10.3390/app11167571

Chicago/Turabian Style

Sung, Yoon-Young, Jae-Woo Shin, Won-Kyung Yang, Min-Jin Kim, Ja-Ik Koo, Eun-Mi Noh, Kyoung-Soo Min, Mi-Young Yun, and Seung-Hyung Kim. 2021. "Effect of Pulsed Electromagnetic Field Stimulation on the Growth Plate of the Tibia Bone of Rats: An In Vivo Study" Applied Sciences 11, no. 16: 7571. https://doi.org/10.3390/app11167571

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