Next Article in Journal
Identifying Energy-Use Behavior and Energy-Use Profiles of Hotel Guests
Next Article in Special Issue
Echocardiography in the Diagnosis and Management of Tricuspid Atresia
Previous Article in Journal
Automatic Handgun Detection with Deep Learning in Video Surveillance Images
Previous Article in Special Issue
Right Ventricular Global and Regional Remodeling in American-Style Football Athletes: A Longitudinal 3D Echocardiographic Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Applied Sciences
Volume 11
Issue 13
10.3390/app11136091
applsci-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study

by
Pietro Scicchitano
1,*,
Marco Tucci
2,
Gabriella Ricci
3,
Michele Gesualdo
1,
Santa Carbonara
3,
Giuseppe Totaro
4,
Annagrazia Cecere
3,
Rosa Carbonara
3,
Francesca Cortese
3,
Vera Loizzi
4,
Gennaro Cormio
4,
Ettore Cicinelli
4 and
Marco Matteo Ciccone
3
1
Cardiology Department, Hospital “F. Perinei” Altamura (BA), ASL BA, 70022 Altamura, Italy
2
Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, Italy
3
Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
4
2nd Unit of Obstetrics and Gynecology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2021, 11(13), 6091; https://doi.org/10.3390/app11136091
Submission received: 7 June 2021 / Revised: 24 June 2021 / Accepted: 26 June 2021 / Published: 30 June 2021
(This article belongs to the Special Issue Advances in Multimodality Approach to Echocardiographic Imaging: Deformation Indexes, 3D-Evaluations, and Future Perspectives)
Browse Figure
Review Reports Versions Notes

Abstract

Background: The aim of this study was to assess the role of cardiac and vascular parameters as all-cause mortality determinants in patients suffering from gynecological cancers. Methods: This was an observational, prospective, non-randomized, and non-controlled study. Forty-seven consecutive patients (mean age: 58 ± 13 years) were enrolled after cancer staging. All patients underwent evaluation of vascular (common carotid intima-media thickness (mean C-IMT), flow-mediated dilation of the brachial artery (FMD), and antero-posterior diameter of the infrarenal abdominal aorta (APAO)) and cardiac function and morphology before cancer-related interventions. A 6-year follow-up was carried out to assess the overall survival of the whole population. Results: Twenty patients (42%) died by the time of the 6-year follow-up. The brachial artery FMD values were higher in the survivors than the non-survivors (9.71 ± 3.53% vs. 6.13 ± 2.62%, p < 0.001), as well as the LVEF (60.8 ± 3.0% vs. 57.8 ± 4.4%, p = 0.009). There were no differences in the mean C-IMT, APAO, and other echocardiographic parameters. ROC curve analysis identified a baseline LVEF < 57% and FMD value < 5.8% as the best cut-offs. Kaplan–Meier evaluation showed that the LVEF, tricuspid annular plane systolic excursion, and FMD were the best predictors of all-cause mortality, although only the LVEF and FMD were confirmed in multivariate Cox regression analysis. Conclusions: The LVEF and brachial artery FMD are independent prognostic determinants in patients with gynecological cancers.
Keywords: gynecological cancer; cardiovascular risk profile; all-cause mortality; baseline evaluation; FMD; LVEF gynecological cancer; cardiovascular risk profile; all-cause mortality; baseline evaluation; FMD; LVEF

Share and Cite

MDPI and ACS Style

Scicchitano, P.; Tucci, M.; Ricci, G.; Gesualdo, M.; Carbonara, S.; Totaro, G.; Cecere, A.; Carbonara, R.; Cortese, F.; Loizzi, V.; et al. Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study. Appl. Sci. 2021, 11, 6091. https://doi.org/10.3390/app11136091

AMA Style

Scicchitano P, Tucci M, Ricci G, Gesualdo M, Carbonara S, Totaro G, Cecere A, Carbonara R, Cortese F, Loizzi V, et al. Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study. Applied Sciences. 2021; 11(13):6091. https://doi.org/10.3390/app11136091

Chicago/Turabian Style

Scicchitano, Pietro, Marco Tucci, Gabriella Ricci, Michele Gesualdo, Santa Carbonara, Giuseppe Totaro, Annagrazia Cecere, Rosa Carbonara, Francesca Cortese, Vera Loizzi, and et al. 2021. "Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study" Applied Sciences 11, no. 13: 6091. https://doi.org/10.3390/app11136091

APA Style

Scicchitano, P., Tucci, M., Ricci, G., Gesualdo, M., Carbonara, S., Totaro, G., Cecere, A., Carbonara, R., Cortese, F., Loizzi, V., Cormio, G., Cicinelli, E., & Ciccone, M. M. (2021). Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study. Applied Sciences, 11(13), 6091. https://doi.org/10.3390/app11136091

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop