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Article

Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study

1
Cardiology Department, Hospital “F. Perinei” Altamura (BA), ASL BA, 70022 Altamura, Italy
2
Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, Italy
3
Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
4
2nd Unit of Obstetrics and Gynecology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Qi-Huang Zheng
Appl. Sci. 2021, 11(13), 6091; https://doi.org/10.3390/app11136091
Received: 7 June 2021 / Revised: 24 June 2021 / Accepted: 26 June 2021 / Published: 30 June 2021
Background: The aim of this study was to assess the role of cardiac and vascular parameters as all-cause mortality determinants in patients suffering from gynecological cancers. Methods: This was an observational, prospective, non-randomized, and non-controlled study. Forty-seven consecutive patients (mean age: 58 ± 13 years) were enrolled after cancer staging. All patients underwent evaluation of vascular (common carotid intima-media thickness (mean C-IMT), flow-mediated dilation of the brachial artery (FMD), and antero-posterior diameter of the infrarenal abdominal aorta (APAO)) and cardiac function and morphology before cancer-related interventions. A 6-year follow-up was carried out to assess the overall survival of the whole population. Results: Twenty patients (42%) died by the time of the 6-year follow-up. The brachial artery FMD values were higher in the survivors than the non-survivors (9.71 ± 3.53% vs. 6.13 ± 2.62%, p < 0.001), as well as the LVEF (60.8 ± 3.0% vs. 57.8 ± 4.4%, p = 0.009). There were no differences in the mean C-IMT, APAO, and other echocardiographic parameters. ROC curve analysis identified a baseline LVEF < 57% and FMD value < 5.8% as the best cut-offs. Kaplan–Meier evaluation showed that the LVEF, tricuspid annular plane systolic excursion, and FMD were the best predictors of all-cause mortality, although only the LVEF and FMD were confirmed in multivariate Cox regression analysis. Conclusions: The LVEF and brachial artery FMD are independent prognostic determinants in patients with gynecological cancers. View Full-Text
Keywords: gynecological cancer; cardiovascular risk profile; all-cause mortality; baseline evaluation; FMD; LVEF gynecological cancer; cardiovascular risk profile; all-cause mortality; baseline evaluation; FMD; LVEF
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MDPI and ACS Style

Scicchitano, P.; Tucci, M.; Ricci, G.; Gesualdo, M.; Carbonara, S.; Totaro, G.; Cecere, A.; Carbonara, R.; Cortese, F.; Loizzi, V.; Cormio, G.; Cicinelli, E.; Ciccone, M.M. Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study. Appl. Sci. 2021, 11, 6091. https://doi.org/10.3390/app11136091

AMA Style

Scicchitano P, Tucci M, Ricci G, Gesualdo M, Carbonara S, Totaro G, Cecere A, Carbonara R, Cortese F, Loizzi V, Cormio G, Cicinelli E, Ciccone MM. Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study. Applied Sciences. 2021; 11(13):6091. https://doi.org/10.3390/app11136091

Chicago/Turabian Style

Scicchitano, Pietro, Marco Tucci, Gabriella Ricci, Michele Gesualdo, Santa Carbonara, Giuseppe Totaro, Annagrazia Cecere, Rosa Carbonara, Francesca Cortese, Vera Loizzi, Gennaro Cormio, Ettore Cicinelli, and Marco M. Ciccone 2021. "Vascular and Cardiac Prognostic Determinants in Patients with Gynecological Cancers: A Six-Year Follow-up Study" Applied Sciences 11, no. 13: 6091. https://doi.org/10.3390/app11136091

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