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Probiotic Potential of a Novel Vitamin B2-Overproducing Lactobacillus plantarum Strain, HY7715, Isolated from Kimchi

R & BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Korea
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Academic Editor: Teresa Gervasi
Appl. Sci. 2021, 11(13), 5765; https://doi.org/10.3390/app11135765
Received: 24 May 2021 / Revised: 17 June 2021 / Accepted: 20 June 2021 / Published: 22 June 2021
(This article belongs to the Special Issue Frontier Research in Food Microbiology)
Vitamin B2, also known as riboflavin, is essential for maintaining human health. The purpose of this study was to isolate novel lactic acid bacteria that overproduce vitamin B2 and to validate their potential as probiotics. In this study, Lactobacillus plantarum HY7715 (HY7715) was selected among lactic acid bacteria isolated from Kimchi. HY7715 showed a very high riboflavin-producing ability compared to the control strain due to the high expression of ribA, ribB, ribC, ribH, and ribG genes. HY7715 produced 34.5 ± 2.41 mg/L of riboflavin for 24 h without consuming riboflavin in the medium under optimal growth conditions. It was able to produce riboflavin in an in vitro model of the intestinal environment. In addition, when riboflavin deficiency was induced in mice through nutritional restriction, higher levels of riboflavin were detected in plasma and urine in the HY7715 administration group than in the control group. HY7715 showed high survival rate in simulated gastrointestinal conditions and had antibiotic resistance below the cutoff MIC value suggested by the European Food Safety Authority; moreover, it did not cause hemolysis. In conclusion, HY7715 could be considered a beneficial probiotic strain for human and animal applications, suggesting that it could be a new alternative to address riboflavin deficiency. View Full-Text
Keywords: riboflavin; vitamin deficiency; lactic acid bacteria; rib operon riboflavin; vitamin deficiency; lactic acid bacteria; rib operon
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MDPI and ACS Style

Kim, J.-Y.; Choi, E.-J.; Lee, J.-H.; Yoo, M.-S.; Heo, K.; Shim, J.-J.; Lee, J.-L. Probiotic Potential of a Novel Vitamin B2-Overproducing Lactobacillus plantarum Strain, HY7715, Isolated from Kimchi. Appl. Sci. 2021, 11, 5765. https://doi.org/10.3390/app11135765

AMA Style

Kim J-Y, Choi E-J, Lee J-H, Yoo M-S, Heo K, Shim J-J, Lee J-L. Probiotic Potential of a Novel Vitamin B2-Overproducing Lactobacillus plantarum Strain, HY7715, Isolated from Kimchi. Applied Sciences. 2021; 11(13):5765. https://doi.org/10.3390/app11135765

Chicago/Turabian Style

Kim, Joo-Yun, Eun-Jung Choi, Jae-Ho Lee, Myeong-Seok Yoo, Keon Heo, Jae-Jung Shim, and Jung-Lyoul Lee. 2021. "Probiotic Potential of a Novel Vitamin B2-Overproducing Lactobacillus plantarum Strain, HY7715, Isolated from Kimchi" Applied Sciences 11, no. 13: 5765. https://doi.org/10.3390/app11135765

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